SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5giv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		3 / 3 GLU A 303
HIS A 266
ASP A 351
 None
ZN  A 601 (-3.4A)
None
 0.59A 1i9gA-5givA:
undetectable		 1i9gA-5givA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 12 HIS A 266
GLU A 267
HIS A 270
GLU A 296
TYR A 422
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
ZN  A 601 (-2.5A)
None
 0.95A 1j36A-5givA:
22.5		 1j36A-5givA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 12 HIS A 266
GLU A 267
HIS A 270
GLU A 296
TYR A 422
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
ZN  A 601 (-2.5A)
None
 0.94A 1j36B-5givA:
22.5		 1j36B-5givA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 11 HIS A 266
GLU A 267
HIS A 270
GLU A 296
TYR A 422
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
ZN  A 601 (-2.5A)
None
 0.98A 1j37A-5givA:
22.4		 1j37A-5givA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 11 HIS A 266
GLU A 267
HIS A 270
GLU A 296
TYR A 422
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
ZN  A 601 (-2.5A)
None
 0.97A 1j37B-5givA:
22.4		 1j37B-5givA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 10 ARG A 300
THR A 350
VAL A 361
GLU A 296
ASP A 407
 None
None
None
ZN  A 601 (-2.5A)
None
 1.48A 1jdvA-5givA:
undetectable
1jdvD-5givA:
undetectable		 1jdvA-5givA:
17.64
1jdvD-5givA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		3 / 3 THR A 249
PRO A 236
THR A 250
 None
 0.83A 1unjF-5givA:
undetectable		 1unjF-5givA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 12 HIS A 266
GLU A 267
HIS A 270
GLU A 296
TYR A 422
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
ZN  A 601 (-2.5A)
None
 1.04A 2c6nB-5givA:
22.0		 2c6nB-5givA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		3 / 3 ARG A 468
GLY A 467
SER A 297
 None
 0.60A 2xctB-5givA:
undetectable		 2xctB-5givA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 7 ASP A 164
SER A 163
SER A 418
ASP A 407
 None
 1.15A 3bc9A-5givA:
undetectable		 3bc9A-5givA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		3 / 3 HIS A 266
GLU A 267
HIS A 270
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
 0.15A 3kecB-5givA:
2.4		 3kecB-5givA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 5 SER A 346
ARG A 251
ASP A 256
THR A 342
 None
 1.40A 3okxA-5givA:
undetectable		 3okxA-5givA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 5 SER A 346
ARG A 251
ASP A 256
THR A 342
 None
 1.39A 3okxB-5givA:
undetectable		 3okxB-5givA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 12 LEU A 484
ILE A 476
GLN A 420
ALA A 292
SER A 291
 None
 1.38A 4a83A-5givA:
undetectable		 4a83A-5givA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 11 HIS A 266
GLU A 267
HIS A 270
GLU A 296
TYR A 422
 ZN  A 601 (-3.4A)
ZN  A 601 ( 4.7A)
ZN  A 601 (-3.4A)
ZN  A 601 (-2.5A)
None
 0.94A 4c2pA-5givA:
23.2		 4c2pA-5givA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		3 / 3 THR A 249
PRO A 236
THR A 250
 None
 0.88A 4hivD-5givA:
undetectable		 4hivD-5givA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		3 / 3 TYR A 357
HIS A 266
ARG A 300
 None
ZN  A 601 (-3.4A)
None
 1.14A 4htfA-5givA:
undetectable		 4htfA-5givA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 7 LEU A 355
ARG A 300
PRO A 196
VAL A 340
 None
 1.18A 4klrA-5givA:
undetectable		 4klrA-5givA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 12 LEU A 305
ARG A 308
ALA A 315
TYR A 221
LEU A 265
 None
 1.08A 4l9qA-5givA:
1.7		 4l9qA-5givA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		3 / 3 GLU A 303
HIS A 266
ASP A 351
 None
ZN  A 601 (-3.4A)
None
 0.64A 5c0oG-5givA:
undetectable		 5c0oG-5givA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 6 GLN A 275
PHE A 225
THR A 233
PHE A 237
 None
 1.44A 5mwyA-5givA:
undetectable		 5mwyA-5givA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 6 PRO A 236
TYR A 221
LEU A 211
LEU A 261
 None
 1.16A 5tl8A-5givA:
undetectable		 5tl8A-5givA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		5 / 12 LEU A 493
VAL A 427
SER A 429
ASN A 426
TYR A 262
 None
 1.30A 5v1tA-5givA:
undetectable		 5v1tA-5givA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 8 VAL A 408
TYR A 116
HIS A 234
GLU A 267
 None
None
None
ZN  A 601 ( 4.7A)
 1.10A 6gneB-5givA:
undetectable		 6gneB-5givA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5giv CARBOXYPEPTIDASE 1
(Deinococcus
radiodurans) 		4 / 5 GLN A 420
GLU A 368
ASP A 407
TYR A 422
 None
 1.38A 6iftA-5givA:
undetectable		 6iftA-5givA:
21.56