SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gj3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 11 LEU A 240
GLY A 304
GLY A 307
ILE A 325
LEU A 334
 None
None
None
None
HEM  A 401 ( 4.7A)
 1.02A 1p91A-5gj3A:
undetectable		 1p91A-5gj3A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 12 ALA A 269
ALA A 267
LEU A 308
GLY A 250
LEU A 238
 None
 1.25A 1qabF-5gj3A:
undetectable		 1qabF-5gj3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		4 / 6 ARG A 339
ASP A 122
TYR A 140
GLU A 107
 None
None
HEM  A 401 (-3.5A)
None
 1.24A 1rjdA-5gj3A:
undetectable		 1rjdA-5gj3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 12 LEU A 236
VAL A 235
ILE A 259
LEU A 328
LEU A 333
 None
 1.12A 1s19A-5gj3A:
undetectable		 1s19A-5gj3A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 11 GLY A 103
ILE A 158
SER A 100
ALA A 201
ILE A 195
 None
 0.93A 2nnhA-5gj3A:
undetectable		 2nnhA-5gj3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 10 PHE A 237
GLY A 264
GLY A 250
LEU A 236
ALA A 267
 None
 0.92A 2v3kA-5gj3A:
undetectable		 2v3kA-5gj3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		4 / 5 VAL A 283
VAL A 284
PHE A 237
ARG A 359
 None
 1.22A 3bjwH-5gj3A:
undetectable		 3bjwH-5gj3A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 12 LEU A 236
THR A 317
GLN A 288
LEU A 314
GLY A 313
 None
 1.34A 3g1uB-5gj3A:
3.5		 3g1uB-5gj3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 12 GLY A 337
GLY A 335
ALA A 190
GLU A 216
ALA A 343
 None
HEM  A 401 ( 4.2A)
None
None
None
 1.08A 3g89A-5gj3A:
undetectable		 3g89A-5gj3A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 11 GLY A 337
GLY A 335
ALA A 190
GLU A 216
ALA A 343
 None
HEM  A 401 ( 4.2A)
None
None
None
 1.09A 3g89B-5gj3A:
undetectable		 3g89B-5gj3A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 12 GLY A 337
GLY A 335
ALA A 190
GLU A 216
ALA A 343
 None
HEM  A 401 ( 4.2A)
None
None
None
 1.09A 3g8bA-5gj3A:
undetectable		 3g8bA-5gj3A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 10 LEU A 236
THR A 317
GLN A 288
LEU A 314
GLY A 313
 None
 1.30A 3h9uA-5gj3A:
3.0		 3h9uA-5gj3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 10 LEU A 236
THR A 317
GLN A 288
LEU A 314
GLY A 313
 None
 1.33A 3h9uC-5gj3A:
3.0		 3h9uC-5gj3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 10 LEU A 236
THR A 317
GLN A 288
LEU A 314
GLY A 313
 None
 1.34A 3h9uD-5gj3A:
3.3		 3h9uD-5gj3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 12 GLY A 320
ALA A 319
ASP A 290
VAL A 294
ARG A 321
 None
 0.95A 3n3iA-5gj3A:
undetectable		 3n3iA-5gj3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		4 / 5 ARG A 142
ASP A 104
ASP A 160
ASP A 184
 HEM  A 401 (-3.2A)
ZN  A 403 (-2.2A)
ZN  A 403 (-2.3A)
ZN  A 403 (-2.9A)
 1.26A 3naiA-5gj3A:
undetectable		 3naiA-5gj3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_2
(ALPHA-GLUCOSIDASE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		4 / 5 PRO A 191
ILE A 195
TYR A 332
MET A 258
 None
 1.31A 3phaA-5gj3A:
undetectable		 3phaA-5gj3A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 12 ILE A 181
LEU A 179
THR A 106
VAL A 118
VAL A 157
 None
 0.99A 3rukA-5gj3A:
undetectable		 3rukA-5gj3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 10 ALA A 162
ARG A 142
GLY A 164
ASP A 122
LEU A 144
 ZN  A 403 ( 4.8A)
HEM  A 401 (-3.2A)
None
None
None
 1.17A 3wdmB-5gj3A:
undetectable		 3wdmB-5gj3A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 11 ILE A 108
ASP A 104
GLY A 335
GLN A 342
GLY A 341
 None
ZN  A 403 (-2.2A)
HEM  A 401 ( 4.2A)
None
None
 1.02A 4ac9B-5gj3A:
5.4
4ac9C-5gj3A:
4.9		 4ac9B-5gj3A:
20.08
4ac9C-5gj3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 10 VAL A 235
LEU A 293
VAL A 291
LEU A 347
THR A 348
 None
 1.02A 4e3hA-5gj3A:
undetectable		 4e3hA-5gj3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 11 LEU A 314
ARG A 323
VAL A 305
LEU A 299
LEU A 238
 None
 1.23A 4or0B-5gj3A:
undetectable		 4or0B-5gj3A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		4 / 7 ALA A 261
ARG A 339
GLY A 337
GLU A 107
 None
 1.00A 5bs8A-5gj3A:
undetectable
5bs8B-5gj3A:
undetectable
5bs8C-5gj3A:
undetectable		 5bs8A-5gj3A:
20.27
5bs8B-5gj3A:
23.61
5bs8C-5gj3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 9 LEU A 144
SER A 145
ILE A 172
PRO A 154
VAL A 157
 None
 1.14A 6ef6A-5gj3A:
undetectable		 6ef6A-5gj3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		5 / 9 LEU A 144
SER A 145
THR A 168
ILE A 172
VAL A 157
 None
 1.30A 6ef6A-5gj3A:
undetectable		 6ef6A-5gj3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5gj3 PERIPLASMIC BINDING
PROTEIN
(Roseiflexus
sp.
RS-1) 		4 / 8 GLY A 242
LEU A 299
GLY A 298
LEU A 240
 None
 0.86A 6mdqA-5gj3A:
undetectable		 6mdqA-5gj3A:
13.39