SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5gj4 SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
(Zika
virus) 		5 / 12 GLY A 128
LEU A  86
VAL A  76
ALA B 164
PHE B 116
 None
 1.18A 1gseA-5gj4A:
undetectable		 1gseA-5gj4A:
21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 9 PHE B  46
THR B  48
VAL B  52
ALA B  56
LEU B  58
 None
 0.70A 2m9qA-5gj4B:
12.9		 2m9qA-5gj4B:
46.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5gj4 SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
(Zika
virus) 		5 / 12 TRP B  69
ASP B  71
VAL B  72
SER A  81
ASN B 152
 None
 1.49A 2y00B-5gj4B:
undetectable		 2y00B-5gj4B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5gj4 SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
(Zika
virus) 		5 / 12 TRP B  69
ASP B  71
VAL B  72
SER A  81
ASN B 152
 None
 1.49A 2y01B-5gj4B:
undetectable		 2y01B-5gj4B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5gj4 SERINE PROTEASE
SUBUNIT NS2B
SERINE PROTEASE NS3
(Zika
virus;
Zika
virus) 		5 / 12 ALA B 164
SER A  85
PHE A  84
GLY A 128
THR A 127
 None
 1.18A 2zifA-5gj4B:
undetectable		 2zifA-5gj4B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 6 PHE B  46
TYR B  79
THR B  53
VAL B  52
 None
 1.23A 3lb3A-5gj4B:
undetectable		 3lb3A-5gj4B:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.92A 3sueC-5gj4B:
12.5		 3sueC-5gj4B:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.77A 3sufD-5gj4B:
12.6		 3sufD-5gj4B:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 6 LEU B  58
TYR B  79
THR B  48
GLY B  37
 None
 1.03A 4l39A-5gj4B:
undetectable		 4l39A-5gj4B:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 9 ILE B 147
TRP B  83
GLN B  96
LEU B 149
LEU B  76
 None
 1.33A 5fhzB-5gj4B:
undetectable		 5fhzB-5gj4B:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 10 ILE B 147
TRP B  83
GLN B  96
LEU B 149
LEU B  76
 None
 1.26A 5fhzC-5gj4B:
undetectable		 5fhzC-5gj4B:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 5 TYR B  23
LYS B  19
GLU B  62
GLY B  61
 None
 1.20A 5jhdJ-5gj4B:
undetectable		 5jhdJ-5gj4B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 5 LEU B  97
LYS B 107
LEU B 128
TYR B 130
 None
 1.49A 5ki6A-5gj4B:
undetectable		 5ki6A-5gj4B:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 12 HIS B  51
THR B  53
ASP B  75
THR B 166
GLY B  37
 None
 1.44A 5utuF-5gj4B:
undetectable		 5utuF-5gj4B:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 5 HIS B  51
ALA B 132
GLY B 151
TYR B 161
 None
 0.40A 5yodB-5gj4B:
28.8		 5yodB-5gj4B:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 5 HIS B  51
SER B 135
GLY B 151
TYR B 161
 None
 0.63A 5yodB-5gj4B:
28.8		 5yodB-5gj4B:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 5 HIS B  51
ALA B 132
SER B 135
GLY B 151
TYR B 161
 None
 0.61A 5yodD-5gj4B:
28.9		 5yodD-5gj4B:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 5 HIS B  51
ALA B 132
TYR B 150
TYR B 161
 None
 0.45A 5yodF-5gj4B:
28.6		 5yodF-5gj4B:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 5 HIS B  51
SER B 135
TYR B 150
TYR B 161
 None
 0.62A 5yodF-5gj4B:
28.6		 5yodF-5gj4B:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		5 / 5 HIS B  51
SER B 135
TYR B 150
GLY B 151
TYR B 161
 None
 0.35A 5yodH-5gj4B:
28.1		 5yodH-5gj4B:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		6 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
VAL B 162
 None
 1.02A 6c2mC-5gj4B:
6.6		 6c2mC-5gj4B:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5gj4 SERINE PROTEASE NS3
(Zika
virus) 		4 / 6 TRP B  83
GLY B 144
ALA B  87
LEU B  85
 None
 1.09A 6fosA-5gj4B:
undetectable		 6fosA-5gj4B:
17.86