SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 TRP A 172
LEU A 125
LYS A  50
 None
 1.33A 1yajK-5gj8A:
undetectable		 1yajK-5gj8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 7 THR A 131
ALA A 368
TYR A 253
LEU A  89
 None
 1.14A 2hzqA-5gj8A:
undetectable		 2hzqA-5gj8A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 VAL A  14
ASP A  13
GLU A  72
 None
 0.70A 2qeuA-5gj8A:
undetectable		 2qeuA-5gj8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 VAL D  14
ASP D  13
GLU D  72
 None
 0.70A 2qeuA-5gj8D:
2.3		 2qeuA-5gj8D:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 VAL A  14
ASP A  13
GLU A  72
 None
 0.72A 2qeuC-5gj8A:
undetectable		 2qeuC-5gj8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 VAL D  14
ASP D  13
GLU D  72
 None
 0.72A 2qeuC-5gj8D:
2.9		 2qeuC-5gj8D:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A 140
GLY A 141
SER A 128
 None
 0.60A 2xctB-5gj8A:
undetectable		 2xctB-5gj8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 ILE D  91
GLY D  85
SER D  86
ALA D  90
VAL D  79
 None
 1.19A 2yvlC-5gj8D:
undetectable		 2yvlC-5gj8D:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 THR A  58
ILE A  97
LYS A  50
THR A 165
LEU A 170
 None
 0.98A 3a50A-5gj8A:
1.1		 3a50A-5gj8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 THR A  58
LEU A  98
ILE A  91
THR A 165
LEU A 170
 None
 1.39A 3a51B-5gj8A:
undetectable		 3a51B-5gj8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLN A 187
LEU A 189
LEU A 170
PHE A 107
SER A 118
 None
 1.21A 3kk6B-5gj8A:
undetectable		 3kk6B-5gj8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 VAL A 234
VAL A 226
ILE A 229
GLN A 230
 None
 1.04A 3remA-5gj8A:
undetectable		 3remA-5gj8A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 VAL A 234
VAL A 226
ILE A 229
GLN A 230
 None
 1.01A 3remB-5gj8A:
undetectable		 3remB-5gj8A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 6 TYR A 155
VAL A 226
THR A 147
THR A 146
 None
 0.78A 3tneA-5gj8A:
undetectable		 3tneA-5gj8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		5 / 7 TYR A 155
VAL A 226
ILE A 229
THR A 147
THR A 146
 None
 0.82A 3tneB-5gj8A:
undetectable		 3tneB-5gj8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 ASN A 338
ALA A 337
TYR A 253
ALA A 368
 None
 1.39A 3twpD-5gj8A:
undetectable		 3twpD-5gj8A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 LEU A 166
SER A 211
LEU A  89
ASN A 372
 None
 1.16A 4n09C-5gj8A:
undetectable		 4n09C-5gj8A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		6 / 12 LEU A 189
LEU A  98
ILE A  97
LEU A 101
ILE A 173
PHE A 107
 None
 1.49A 4odrA-5gj8A:
undetectable
4odrB-5gj8A:
undetectable		 4odrA-5gj8A:
13.92
4odrB-5gj8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		6 / 11 LEU A 189
LEU A  98
ILE A  97
LEU A 101
ILE A 173
PHE A 107
 None
 1.47A 4odrA-5gj8A:
undetectable
4odrB-5gj8A:
undetectable		 4odrA-5gj8A:
13.92
4odrB-5gj8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 THR A 203
ASP A 365
GLU A 360
 None
 0.79A 5fa8A-5gj8A:
undetectable		 5fa8A-5gj8A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 PRO A  42
LEU A  24
SER A  86
 None
 0.61A 5fsaB-5gj8A:
undetectable		 5fsaB-5gj8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		3 / 3 PRO D  42
LEU D  24
SER D  86
 None
 0.54A 5fsaB-5gj8D:
undetectable		 5fsaB-5gj8D:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 6 ILE A 256
TYR A 253
THR A 203
TRP A 201
 None
 1.21A 5g08A-5gj8A:
undetectable		 5g08A-5gj8A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 5 GLY A  85
ASP A  84
ARG A 361
MET A 293
 None
 1.22A 5gwkA-5gj8A:
1.2		 5gwkA-5gj8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN
(Alicyclobacillus
acidocaldarius) 		4 / 8 ARG A 261
ALA A 260
GLY A 255
ALA A 337
 None
 0.79A 6mdqA-5gj8A:
undetectable		 6mdqA-5gj8A:
13.78