SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gje'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A  48
ALA A  35
VAL A  37
 None
 0.94A 1bdwA-5gjeA:
undetectable
1bdwB-5gjeA:
undetectable		 1bdwA-5gjeA:
8.50
1bdwB-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 LEU A  81
LEU A 105
LEU A 170
LEU A 177
 None
 0.73A 1errA-5gjeA:
undetectable		 1errA-5gjeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 GLU A  32
ALA A  34
SER A  49
 None
 0.56A 1errB-5gjeA:
undetectable		 1errB-5gjeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK4_A_T44A1008_1
(SERUM ALBUMIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 10 ASP B1110
ALA B1108
GLU B1067
ASN B1065
VAL B1063
 None
 1.25A 1hk4A-5gjeB:
undetectable		 1hk4A-5gjeB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 10 ASP B1110
ALA B1108
GLU B1067
ASN B1065
VAL B1063
 None
 1.21A 1hk5A-5gjeB:
undetectable		 1hk5A-5gjeB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 ILE A 389
ILE A 365
TYR A 356
ALA A 395
THR A 411
 None
 1.15A 1jtxA-5gjeA:
undetectable		 1jtxA-5gjeA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 TYR A 348
ILE A 355
GLY A 353
ILE A 370
 None
 0.91A 1mrjA-5gjeA:
undetectable		 1mrjA-5gjeA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 4 ILE A 333
ASP A 371
LEU A 311
ARG A 316
 None
 1.25A 2a7qA-5gjeA:
undetectable		 2a7qA-5gjeA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 5 ILE B 961
LEU B 959
ALA B 992
PHE B 935
 None
 1.02A 2opxA-5gjeB:
undetectable		 2opxA-5gjeB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 TYR B 844
TYR B 846
GLN B 870
ILE B 869
 NAG  B1304 ( 4.9A)
None
None
None
 1.21A 2pgzD-5gjeB:
undetectable
2pgzE-5gjeB:
undetectable		 2pgzD-5gjeB:
20.33
2pgzE-5gjeB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 VAL A 141
TRP A 164
TRP A 138
 None
 0.96A 2xdcC-5gjeA:
undetectable
2xdcD-5gjeA:
undetectable		 2xdcC-5gjeA:
8.50
2xdcD-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A 138
VAL A 141
TRP A 164
 None
 1.16A 2xdcC-5gjeA:
undetectable
2xdcD-5gjeA:
undetectable		 2xdcC-5gjeA:
8.50
2xdcD-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A 138
VAL A 141
TRP A 164
 None
 1.09A 2xdcE-5gjeA:
undetectable
2xdcF-5gjeA:
undetectable		 2xdcE-5gjeA:
8.50
2xdcF-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 5 ARG A 546
ASP A 511
ILE A 513
GLU A 537
 None
 1.25A 2xrzA-5gjeA:
undetectable
2xrzB-5gjeA:
undetectable		 2xrzA-5gjeA:
21.94
2xrzB-5gjeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A 138
VAL A 141
TRP A 164
 None
 1.15A 2y5mE-5gjeA:
undetectable
2y5mF-5gjeA:
undetectable		 2y5mE-5gjeA:
8.50
2y5mF-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A 138
VAL A 141
TRP A 164
 None
 1.12A 2y6nC-5gjeA:
undetectable
2y6nD-5gjeA:
undetectable		 2y6nC-5gjeA:
8.50
2y6nD-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A 138
VAL A 141
TRP A 164
 None
 1.14A 2y6nE-5gjeA:
undetectable
2y6nF-5gjeA:
undetectable		 2y6nE-5gjeA:
8.50
2y6nF-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 7 GLY B 760
GLU B 759
GLU B 782
ALA B 906
 None
 0.82A 3fpjB-5gjeB:
undetectable		 3fpjB-5gjeB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 VAL A 433
ILE A 516
ASN A 474
GLY A 475
 None
 0.72A 3hjoB-5gjeA:
undetectable		 3hjoB-5gjeA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 PHE B 633
SER B 884
ARG B 644
VAL B 671
 None
 1.24A 3jx1A-5gjeB:
undetectable
3jx1B-5gjeB:
undetectable		 3jx1A-5gjeB:
20.07
3jx1B-5gjeB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 VAL A 539
VAL A 548
TRP A 528
 None
 0.87A 3l8lA-5gjeA:
undetectable
3l8lB-5gjeA:
undetectable		 3l8lA-5gjeA:
8.50
3l8lB-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 VAL A 539
VAL A 548
TRP A 528
 None
 0.92A 3l8lC-5gjeA:
undetectable
3l8lD-5gjeA:
undetectable		 3l8lC-5gjeA:
8.50
3l8lD-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_1
(16S RRNA METHYLASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 4 ASN A   8
ASP A  33
GLU A  96
TRP A 223
 None
 0.80A 3mteA-5gjeA:
0.0		 3mteA-5gjeA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 ASP A 387
ILE A 344
GLY A 558
VAL A 433
 None
 0.91A 3n3iA-5gjeA:
undetectable		 3n3iA-5gjeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 PHE B 633
SER B 884
ARG B 644
VAL B 671
 None
 1.25A 3nlyA-5gjeB:
undetectable
3nlyB-5gjeB:
undetectable		 3nlyA-5gjeB:
20.07
3nlyB-5gjeB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 PHE B 633
SER B 884
ARG B 644
VAL B 671
 None
 1.26A 3rqlA-5gjeB:
undetectable
3rqlB-5gjeB:
undetectable		 3rqlA-5gjeB:
20.07
3rqlB-5gjeB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 GLY A 459
ALA A 455
ASP A 461
GLY A 439
ILE A 432
 None
 1.11A 3s56A-5gjeA:
undetectable		 3s56A-5gjeA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP A 138
VAL A 141
TRP A 164
 None
 1.02A 3zq8A-5gjeA:
undetectable
3zq8B-5gjeA:
undetectable		 3zq8A-5gjeA:
8.50
3zq8B-5gjeA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 9 TRP A 220
LEU A 239
GLY A 238
VAL A 200
VAL A 201
 None
 1.37A 4c9kB-5gjeA:
undetectable		 4c9kB-5gjeA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 9 TRP A 220
LEU A 239
GLY A 238
VAL A 200
VAL A 201
 None
 1.38A 4c9pA-5gjeA:
undetectable		 4c9pA-5gjeA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 PHE B 633
SER B 884
ARG B 644
VAL B 671
 None
 1.27A 4capA-5gjeB:
undetectable
4capB-5gjeB:
undetectable		 4capA-5gjeB:
20.07
4capB-5gjeB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 PHE B 633
SER B 884
ARG B 644
VAL B 671
 None
 1.22A 4d32A-5gjeB:
undetectable
4d32B-5gjeB:
undetectable		 4d32A-5gjeB:
20.07
4d32B-5gjeB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 LEU A 585
LEU A 421
ILE A 420
TRP A 400
 None
 0.77A 4do3B-5gjeA:
undetectable		 4do3B-5gjeA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 ASP A 406
ASP A 402
GLU A 428
ASP A 360
 None
 1.01A 4gkhC-5gjeA:
undetectable
4gkhK-5gjeA:
undetectable		 4gkhC-5gjeA:
19.70
4gkhK-5gjeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 ASP A 406
ASP A 402
GLU A 428
ASP A 360
 None
 0.98A 4gkiE-5gjeA:
undetectable
4gkiG-5gjeA:
undetectable		 4gkiE-5gjeA:
19.70
4gkiG-5gjeA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU A 320
LEU A 335
ILE A 550
ILE A 323
LEU A 559
 None
 1.18A 4j24C-5gjeA:
undetectable		 4j24C-5gjeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU A 320
LEU A 335
ILE A 550
ILE A 323
LEU A 559
 None
 1.22A 4j26B-5gjeA:
undetectable		 4j26B-5gjeA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 ARG A 197
GLU A 161
PHE A 186
 None
 0.99A 4kszA-5gjeA:
undetectable		 4kszA-5gjeA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 7 THR B 812
LEU B 814
VAL B 827
VAL B 787
 None
 1.06A 4l4gA-5gjeB:
undetectable		 4l4gA-5gjeB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 SER B1025
HIS B1205
TYR B1029
GLU B1067
 None
 1.12A 4ms4A-5gjeB:
undetectable		 4ms4A-5gjeB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 5 ASN B 727
PRO B 750
GLY B 725
ASP B 809
 None
 0.97A 4n48B-5gjeB:
undetectable		 4n48B-5gjeB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 PRO B 707
GLU B 708
ALA B 666
GLY B 795
LEU B 796
 None
 1.05A 4oaeA-5gjeB:
undetectable		 4oaeA-5gjeB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 LEU B 873
MET B 877
TYR B 846
 None
 0.81A 4p6xG-5gjeB:
undetectable		 4p6xG-5gjeB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 7 LEU B1076
ILE B1105
LYS B1103
VAL B1148
 None
 1.21A 4tvtA-5gjeB:
undetectable		 4tvtA-5gjeB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 GLU B 697
ASP B 673
ASP B 668
ASP B 735
 None
NAG  B1302 ( 4.8A)
None
None
 1.03A 4uckB-5gjeB:
undetectable		 4uckB-5gjeB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 PHE B 633
SER B 884
ARG B 644
VAL B 671
 None
 1.23A 4v3yA-5gjeB:
undetectable
4v3yB-5gjeB:
undetectable		 4v3yA-5gjeB:
20.07
4v3yB-5gjeB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 ARG B 728
ASP B 956
HIS B 919
ARG B 946
 None
 1.41A 5a06A-5gjeB:
undetectable		 5a06A-5gjeB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TYR A 178
LYS A 176
LYS A 189
 None
 1.04A 5dbyA-5gjeA:
undetectable		 5dbyA-5gjeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 7 THR A 503
ASP A 501
GLY A 483
TYR A 442
 None
 1.05A 5hwaA-5gjeA:
undetectable		 5hwaA-5gjeA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 ILE B1167
VAL B1181
ASN B1155
GLU B1154
ILE B 949
 None
 1.02A 5lg3E-5gjeB:
undetectable		 5lg3E-5gjeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 ILE B1167
VAL B1181
ASN B1155
GLU B1154
ILE B 949
 None
 0.96A 5lg3J-5gjeB:
undetectable		 5lg3J-5gjeB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 LEU B 667
ILE B 845
THR B 839
TRP B 847
 None
 1.36A 5ljeA-5gjeB:
undetectable		 5ljeA-5gjeB:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		5 / 12 VAL B 790
GLU B 816
ALA B 793
ARG B 825
LEU B 805
 None
 1.44A 5m54B-5gjeB:
undetectable		 5m54B-5gjeB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 LEU A 168
LEU A 211
TRP A 220
 None
 0.90A 5nwuA-5gjeA:
undetectable		 5nwuA-5gjeA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 LEU B 753
LEU B 796
TRP B 807
 None
 0.84A 5nwuA-5gjeB:
undetectable		 5nwuA-5gjeB:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 GLY B1049
THR B1041
ASN B1039
 None
NAG  B1307 (-2.9A)
NAG  B1307 (-1.7A)
 0.65A 5odiG-5gjeB:
undetectable		 5odiG-5gjeB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 8 SER B 884
ARG B 644
VAL B 671
PHE B 633
 None
 1.23A 5uo7A-5gjeB:
undetectable
5uo7B-5gjeB:
undetectable		 5uo7A-5gjeB:
19.97
5uo7B-5gjeB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 4 VAL A 410
LEU A 398
LEU A 413
ASP A 349
 None
None
PO4  A 708 (-4.5A)
None
 1.26A 5xv7A-5gjeA:
undetectable		 5xv7A-5gjeA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 4 VAL B 731
LEU B 719
LEU B 734
ASP B 670
 None
 1.29A 5xv7A-5gjeB:
2.6		 5xv7A-5gjeB:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLU A 448
ARG B 853
ASP B 874
ASP A 425
 None
 1.29A 5zw4A-5gjeA:
undetectable		 5zw4A-5gjeA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 GLY A  80
ASP A  79
SER A  95
ARG A 122
 None
 1.02A 6dwdA-5gjeA:
undetectable
6dwdC-5gjeA:
undetectable		 6dwdA-5gjeA:
22.91
6dwdC-5gjeA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 GLY B 822
ASN B 819
SER B 817
ARG B 825
 None
 1.07A 6dwdA-5gjeB:
undetectable
6dwdC-5gjeB:
undetectable		 6dwdA-5gjeB:
21.78
6dwdC-5gjeB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		4 / 6 ASP B 956
ARG B 728
GLN B1182
GLN B 940
 None
 1.44A 6g31L-5gjeB:
undetectable		 6g31L-5gjeB:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens) 		3 / 3 TRP B1030
ILE B1014
GLU B1033
 None
 0.76A 6hcxA-5gjeB:
11.3		 6hcxA-5gjeB:
9.32