SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 SER A  54
ILE A  32
ALA A  59
ALA A  93
 AMP  A 301 (-4.1A)
None
None
None
 0.98A 1w0gA-5gjuA:
undetectable		 1w0gA-5gjuA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		5 / 12 GLY A 152
SER A 151
GLY A 180
VAL A  79
ASP A 156
 None
 0.97A 2b25B-5gjuA:
undetectable		 2b25B-5gjuA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 8 ARG A 135
GLY A 134
THR A 172
ILE A 173
 None
 0.91A 2f9wA-5gjuA:
undetectable
2f9wB-5gjuA:
undetectable		 2f9wA-5gjuA:
22.63
2f9wB-5gjuA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		3 / 3 ARG A 135
ASP A 169
ASP A 138
 None
 0.86A 3jayA-5gjuA:
undetectable		 3jayA-5gjuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		3 / 3 ARG A 135
ASP A 169
ASP A 138
 None
 0.88A 3jb2A-5gjuA:
undetectable		 3jb2A-5gjuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		3 / 3 ARG A 135
ASP A 169
ASP A 138
 None
 0.87A 3jb3A-5gjuA:
undetectable		 3jb3A-5gjuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		5 / 12 GLY A 152
ILE A  37
ALA A 184
PHE A 186
ALA A  59
 None
 0.98A 3sudC-5gjuA:
undetectable		 3sudC-5gjuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		5 / 12 GLY A 152
VAL A 129
ALA A 184
PHE A 186
ALA A  59
 None
 1.02A 3sugA-5gjuA:
undetectable		 3sugA-5gjuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 THR A  52
GLY A  55
ARG A 209
ILE A  32
 AMP  A 301 (-3.6A)
AMP  A 301 (-3.3A)
None
None
 1.07A 4ac9C-5gjuA:
3.3		 4ac9C-5gjuA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 THR A  52
GLY A  55
ARG A 209
ILE A  32
 AMP  A 301 (-3.6A)
AMP  A 301 (-3.3A)
None
None
 1.10A 4acaC-5gjuA:
3.1		 4acaC-5gjuA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		5 / 12 LEU A 155
LEU A 136
VAL A  79
GLY A 131
LEU A  86
 None
 1.08A 4otyA-5gjuA:
undetectable		 4otyA-5gjuA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		5 / 12 LEU A 155
LEU A 136
VAL A  79
GLY A 131
LEU A  86
 None
 1.08A 4otyB-5gjuA:
undetectable		 4otyB-5gjuA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		3 / 3 GLY A 134
PRO A 133
ALA A  81
 None
 0.51A 4qn9B-5gjuA:
undetectable		 4qn9B-5gjuA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 7 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.94A 4w5oA-5gjuA:
undetectable		 4w5oA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.95A 4w5qA-5gjuA:
undetectable		 4w5qA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.99A 4w5tA-5gjuA:
undetectable		 4w5tA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.93A 4z4cA-5gjuA:
undetectable		 4z4cA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.95A 4z4dA-5gjuA:
undetectable		 4z4dA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 7 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.96A 4z4eA-5gjuA:
2.1		 4z4eA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 7 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.96A 4z4gA-5gjuA:
2.1		 4z4gA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 PHE A 166
PRO A 133
MET A 161
LEU A 137
 None
 1.48A 5dzka-5gjuA:
undetectable
5dzko-5gjuA:
undetectable		 5dzka-5gjuA:
22.61
5dzko-5gjuA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		3 / 3 VAL A 129
VAL A 107
GLN A 118
 None
 0.66A 5qhaA-5gjuA:
undetectable		 5qhaA-5gjuA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5gju ATP-DEPENDENT RNA
HELICASE DEAD
(Escherichia
coli) 		4 / 6 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 1.00A 6cbdA-5gjuA:
undetectable		 6cbdA-5gjuA:
13.88