SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gjv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 SER A1143
GLU A1144
GLU A1145
 None
 0.62A 1eqbD-5gjvA:
undetectable		 1eqbD-5gjvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 SER A1143
GLU A1144
GLU A1145
 None
 0.63A 1eqbB-5gjvA:
undetectable		 1eqbB-5gjvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Oryctolagus
cuniculus) 		4 / 7 GLN A 372
MET A 367
MET C 292
ALA C 296
 None
 1.07A 1linA-5gjvA:
undetectable		 1linA-5gjvA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ILE A 822
PHE A1306
GLN A1311
ASN A1304
LEU A1294
 None
None
PC1  A1915 (-3.7A)
None
None
 1.45A 1u70A-5gjvA:
undetectable		 1u70A-5gjvA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 9 VAL A 610
LEU A 611
PHE A 597
PHE A 567
LEU A 644
 None
 1.36A 1wrkA-5gjvA:
undetectable
1wrkB-5gjvA:
undetectable		 1wrkA-5gjvA:
5.01
1wrkB-5gjvA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 6 ALA A 101
GLU A 100
ILE A  99
LEU A 125
 None
 0.93A 1xvaA-5gjvA:
undetectable
1xvaB-5gjvA:
undetectable		 1xvaA-5gjvA:
10.28
1xvaB-5gjvA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 11 PHE A 804
ILE A 805
THR A 799
ALA A 798
VAL A 842
 None
 1.25A 2gl0B-5gjvA:
undetectable
2gl0C-5gjvA:
undetectable		 2gl0B-5gjvA:
6.54
2gl0C-5gjvA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 7 THR A1132
ALA A1250
PHE A1125
LEU A 201
 PC1  A1912 (-4.3A)
None
None
None
 1.13A 2hzqA-5gjvA:
undetectable		 2hzqA-5gjvA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 GLY A 613
GLY A1015
THR A 612
LEU A 611
ASP A 615
 None
 1.01A 2oxtC-5gjvA:
undetectable		 2oxtC-5gjvA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 TRP A1016
THR A 612
VAL A 610
VAL A 619
PHE A 597
 None
 1.42A 2y04B-5gjvA:
4.8		 2y04B-5gjvA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 ALA A 443
ILE A 439
ILE A 538
TYR A 541
 None
 0.96A 2zm8A-5gjvA:
undetectable		 2zm8A-5gjvA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 ALA A 443
ILE A 439
ILE A 538
TYR A 541
 None
 0.97A 2zmaA-5gjvA:
undetectable		 2zmaA-5gjvA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ASN A 654
VAL A 655
GLY A 648
TYR A 650
ILE A 643
 None
None
None
PC1  A1906 ( 4.8A)
PC1  A1903 ( 4.5A)
 1.35A 3bwmA-5gjvA:
undetectable		 3bwmA-5gjvA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 TYR A 299
ASP A 303
GLY A 306
SER A 250
ASN A1301
 None
 1.20A 3hiiA-5gjvA:
undetectable		 3hiiA-5gjvA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 10 ALA A1266
LEU A 914
VAL A 917
ILE A1274
LEU A1371
 None
None
None
PC1  A1915 ( 4.6A)
None
 1.15A 3jw5B-5gjvA:
undetectable		 3jw5B-5gjvA:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 6 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.96A 3ko0B-5gjvA:
undetectable		 3ko0B-5gjvA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 6 LEU A 471
SER A 473
PHE A 475
ILE A 441
 None
 0.93A 3ko0S-5gjvA:
undetectable		 3ko0S-5gjvA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 11 LEU A 186
SER A 177
LEU A 173
LEU A 565
LEU A 568
 None
 1.39A 3ndvA-5gjvA:
undetectable
3ndvB-5gjvA:
undetectable		 3ndvA-5gjvA:
11.58
3ndvB-5gjvA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 11 LEU A 565
LEU A 568
LEU A 186
SER A 177
LEU A 173
 None
 1.41A 3ndvC-5gjvA:
undetectable
3ndvD-5gjvA:
undetectable		 3ndvC-5gjvA:
11.58
3ndvD-5gjvA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A 662
GLU A 668
SER A 561
 None
 0.76A 3p2kA-5gjvA:
undetectable		 3p2kA-5gjvA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 LEU A1020
LEU A 604
GLN A 602
PHE A 597
SER A 606
 None
PC1  A1914 ( 4.3A)
None
None
None
 1.36A 3tbgA-5gjvA:
2.6		 3tbgA-5gjvA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 LEU A1020
LEU A 604
GLN A 602
PHE A 597
SER A 606
 None
PC1  A1914 ( 4.3A)
None
None
None
 1.34A 3tbgC-5gjvA:
2.6		 3tbgC-5gjvA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 7 TRP A 294
PHE A 275
VAL A 301
ILE A 318
 None
 0.99A 3zjqA-5gjvA:
undetectable		 3zjqA-5gjvA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		3 / 3 GLN C 438
ASP A 362
GLN A 358
 None
 0.91A 4aztA-5gjvC:
undetectable		 4aztA-5gjvC:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.88A 4fp9D-5gjvA:
undetectable		 4fp9D-5gjvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 LEU A 175
ARG A 174
MET A 103
 None
 0.97A 4m11C-5gjvA:
undetectable		 4m11C-5gjvA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 LEU A 472
ASN A 468
LEU A 512
ILE A 524
 None
 1.02A 4ok1A-5gjvA:
1.5		 4ok1A-5gjvA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 9 ALA A 660
LEU A 562
SER A 334
LEU A 333
VAL A 332
 None
 1.20A 4or0A-5gjvA:
undetectable		 4or0A-5gjvA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 LYS A1291
LYS A 894
ALA A 824
 None
 1.13A 4ot2A-5gjvA:
4.1		 4ot2A-5gjvA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1030
HIS A 454
LYS A 953
 None
 0.79A 4qzuD-5gjvA:
undetectable		 4qzuD-5gjvA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		4 / 5 PHE B 103
PRO C 272
VAL C 270
ALA B 104
 None
 1.31A 4w5oA-5gjvB:
undetectable		 4w5oA-5gjvB:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ASN A 654
VAL A 655
GLY A 648
TYR A 650
ILE A 643
 None
None
None
PC1  A1906 ( 4.8A)
PC1  A1903 ( 4.5A)
 1.33A 4xucA-5gjvA:
undetectable		 4xucA-5gjvA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 6 ILE A 128
PHE A 131
ARG A 168
GLU A  87
 None
 1.45A 4zzcB-5gjvA:
4.6
4zzcC-5gjvA:
4.6		 4zzcB-5gjvA:
10.62
4zzcC-5gjvA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ARG A 986
LYS A 976
GLU A 984
 None
 0.65A 5d0yA-5gjvA:
undetectable		 5d0yA-5gjvA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 ASN A 654
VAL A 655
GLY A 648
TYR A 650
ILE A 643
 None
None
None
PC1  A1906 ( 4.8A)
PC1  A1903 ( 4.5A)
 1.35A 5lsaA-5gjvA:
undetectable		 5lsaA-5gjvA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Oryctolagus
cuniculus) 		5 / 9 PRO B 160
TYR B 111
ILE B 126
VAL B 119
ILE B 146
 None
 1.25A 5mvnB-5gjvB:
undetectable		 5mvnB-5gjvB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1
(Oryctolagus
cuniculus) 		5 / 10 PRO B 160
TYR B 111
ILE B 126
VAL B 119
ILE B 146
 None
 1.25A 5mvnD-5gjvB:
undetectable		 5mvnD-5gjvB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 7 GLY A 293
GLU A1323
ALA A1324
ASP A 615
 None
 0.82A 5mvsA-5gjvA:
undetectable		 5mvsA-5gjvA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 GLY A 293
GLU A1323
ALA A1324
ASP A 615
 None
 0.83A 5mvsB-5gjvA:
2.0		 5mvsB-5gjvA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ARG A 897
PHE A 843
LEU A 816
 None
 0.93A 5x1bC-5gjvA:
7.6		 5x1bC-5gjvA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.85A 5zvgA-5gjvA:
undetectable		 5zvgA-5gjvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		3 / 3 ASP A1196
ARG A1236
ASP A1203
 None
 0.81A 5zvgB-5gjvA:
undetectable		 5zvgB-5gjvA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		5 / 12 GLY A 634
HIS A 274
LEU A 283
ILE A 639
MET A 620
 None
None
PC1  A1913 ( 4.7A)
PC1  A1903 ( 4.6A)
None
 1.41A 6md4A-5gjvA:
undetectable		 6md4A-5gjvA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 HIS A 270
GLU A 591
ASP A 589
GLU A 588
 None
 1.25A 6mn4C-5gjvA:
undetectable		 6mn4C-5gjvA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S
(Oryctolagus
cuniculus) 		4 / 8 TRP A 300
ARG A1318
GLU A1323
GLU A1327
 None
 1.15A 6mn4D-5gjvA:
undetectable		 6mn4D-5gjvA:
9.14