SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ALA A 199
SER A 153
THR A 151
VAL A 149
 None
 0.87A 1dvxB-5gk2A:
undetectable		 1dvxB-5gk2A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 PHE A 329
GLU A 349
VAL A 334
ASN A 331
 None
 1.50A 1jqdA-5gk2A:
undetectable		 1jqdA-5gk2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 1.01A 1v54N-5gk2A:
undetectable
1v54W-5gk2A:
undetectable		 1v54N-5gk2A:
19.85
1v54W-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 5 PRO A 156
GLY A 336
ASN A 337
GLY A 339
 None
 1.06A 1zlqA-5gk2A:
undetectable		 1zlqA-5gk2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 1.00A 2dyrN-5gk2A:
undetectable
2dyrW-5gk2A:
undetectable		 2dyrN-5gk2A:
19.85
2dyrW-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 11 ALA A  92
THR A 151
ALA A  67
ALA A  71
VAL A  74
 None
 1.03A 2qhfA-5gk2A:
undetectable		 2qhfA-5gk2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		3 / 3 SER A 313
ARG A 309
GLN A 325
 None
 1.01A 2xnrA-5gk2A:
undetectable		 2xnrA-5gk2A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.96A 2zxwN-5gk2A:
undetectable
2zxwW-5gk2A:
undetectable		 2zxwN-5gk2A:
19.85
2zxwW-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 5 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.96A 3abkN-5gk2A:
undetectable
3abkW-5gk2A:
undetectable		 3abkN-5gk2A:
19.85
3abkW-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.99A 3ablA-5gk2A:
undetectable
3ablJ-5gk2A:
undetectable		 3ablA-5gk2A:
19.85
3ablJ-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 8 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.93A 3ablN-5gk2A:
undetectable
3ablW-5gk2A:
undetectable		 3ablN-5gk2A:
19.85
3ablW-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.97A 3ag2N-5gk2A:
undetectable
3ag2W-5gk2A:
undetectable		 3ag2N-5gk2A:
19.85
3ag2W-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.98A 3ag4N-5gk2A:
undetectable
3ag4W-5gk2A:
undetectable		 3ag4N-5gk2A:
19.85
3ag4W-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 ALA A 199
SER A 153
THR A 151
VAL A 149
 None
 0.81A 3d2tB-5gk2A:
undetectable		 3d2tB-5gk2A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 12 ASN A  45
SER A 304
ASN A 337
SER A 369
ASN A 270
 None
 1.24A 3havC-5gk2A:
undetectable		 3havC-5gk2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 12 VAL A 149
LEU A  90
ALA A 341
GLY A  76
LEU A  84
 None
 1.00A 3ln1A-5gk2A:
undetectable		 3ln1A-5gk2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 12 VAL A 149
LEU A  90
ALA A 341
GLY A  76
LEU A  84
 None
 1.01A 3ln1B-5gk2A:
undetectable		 3ln1B-5gk2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 12 VAL A 149
LEU A  90
ALA A 341
GLY A  76
LEU A  84
 None
 1.00A 3ln1C-5gk2A:
undetectable		 3ln1C-5gk2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 12 VAL A 149
LEU A  90
ALA A 341
GLY A  76
LEU A  84
 None
 1.00A 3ln1D-5gk2A:
undetectable		 3ln1D-5gk2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 10 THR A 122
GLY A 198
TYR A 344
GLY A 124
ALA A 128
 None
 1.32A 3pp7B-5gk2A:
undetectable		 3pp7B-5gk2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 12 GLY A  95
GLY A 129
SER A 340
ALA A 197
SER A  11
 None
 1.25A 3sueD-5gk2A:
undetectable		 3sueD-5gk2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.97A 3wg7A-5gk2A:
undetectable
3wg7J-5gk2A:
undetectable		 3wg7A-5gk2A:
19.85
3wg7J-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.99A 3wg7N-5gk2A:
undetectable
3wg7W-5gk2A:
undetectable		 3wg7N-5gk2A:
19.85
3wg7W-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		5 / 9 ALA A  91
ILE A 215
ALA A 148
THR A 145
ILE A 120
 None
 1.08A 4r21B-5gk2A:
undetectable		 4r21B-5gk2A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 1.01A 5b1bA-5gk2A:
undetectable
5b1bJ-5gk2A:
undetectable		 5b1bA-5gk2A:
19.85
5b1bJ-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 LYS A  49
TYR A  50
PRO A  18
TYR A  53
 None
 1.37A 5bmvB-5gk2A:
undetectable		 5bmvB-5gk2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.97A 5iy5A-5gk2A:
undetectable
5iy5J-5gk2A:
undetectable		 5iy5A-5gk2A:
19.85
5iy5J-5gk2A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 8 ILE A 220
ILE A 215
ALA A 136
LEU A 138
 None
 0.74A 5og9A-5gk2A:
undetectable		 5og9A-5gk2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.99A 5z86N-5gk2A:
undetectable
5z86W-5gk2A:
undetectable		 5z86N-5gk2A:
19.85
5z86W-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 1.00A 5zcoN-5gk2A:
undetectable
5zcoW-5gk2A:
undetectable		 5zcoN-5gk2A:
19.85
5zcoW-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 VAL A  42
ASN A  46
ASN A 337
ILE A  48
 None
 1.13A 6h7uA-5gk2A:
undetectable		 6h7uA-5gk2A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 7 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.98A 6nmfA-5gk2A:
undetectable
6nmfJ-5gk2A:
undetectable		 6nmfA-5gk2A:
19.85
6nmfJ-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gk2 KETOSYNTHASE STLD
(Photorhabdus
laumondii) 		4 / 6 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 1.08A 6nmfN-5gk2A:
undetectable
6nmfW-5gk2A:
undetectable		 6nmfN-5gk2A:
19.85
6nmfW-5gk2A:
8.50