SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 10 LEU A 421
VAL A 438
VAL A 409
TYR A 417
GLY A 411
None
1.43A 1fkoA-5gk9A:
undetectable
1fkoA-5gk9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 10 MET A 564
LEU A 575
LEU A 573
GLU B  58
LEU A 531
None
1.04A 1gwrA-5gk9A:
undetectable
1gwrA-5gk9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
4 / 5 PRO A 552
VAL A 556
VAL B  40
ILE B  53
None
1.03A 1z2bC-5gk9A:
undetectable
1z2bC-5gk9A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 11 MET A 478
LEU A 424
LEU A 421
PRO A 394
VAL A 409
None
1.39A 2po5B-5gk9A:
undetectable
2po5B-5gk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 11 MET A 564
LEU A 575
LEU A 573
GLU B  58
LEU A 531
None
1.05A 3hm1B-5gk9A:
undetectable
3hm1B-5gk9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 12 MET A 564
LEU A 575
LEU A 573
GLU B  58
LEU A 531
None
1.08A 3olsA-5gk9A:
undetectable
3olsA-5gk9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 12 MET A 564
LEU A 575
LEU A 573
GLU B  58
LEU A 531
None
1.06A 3q95B-5gk9A:
undetectable
3q95B-5gk9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
3 / 3 TYR A 519
LEU A 580
ARG A 520
None
0.79A 3sufB-5gk9A:
undetectable
3sufB-5gk9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 12 MET A 478
LEU A 424
LEU A 421
PRO A 394
VAL A 409
None
1.36A 3w1wB-5gk9A:
undetectable
3w1wB-5gk9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 9 ILE A 555
GLN A 560
LEU A 559
VAL A 574
LEU A 527
None
1.20A 4g1bC-5gk9A:
undetectable
4g1bC-5gk9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)
5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
5 / 12 MET A 564
LEU A 575
LEU A 573
GLU B  58
LEU A 531
None
1.07A 4pxmA-5gk9A:
undetectable
4pxmA-5gk9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
4 / 6 LEU A 514
ILE A 457
THR A 477
MET A 446
ACO  A 702 (-3.4A)
None
ACO  A 702 (-3.0A)
None
1.23A 5ljeA-5gk9A:
undetectable
5ljeA-5gk9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo
sapiens)
4 / 6 LYS A 602
LEU A 601
PHE A 493
LEU A 497
None
1.13A 5x19P-5gk9A:
undetectable
5x19P-5gk9A:
20.27