SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gkf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5gkf ENDONUCLEASE ENDOMS
(Thermococcus
kodakarensis) 		4 / 6 LEU A 212
ALA A 221
SER A 216
THR A 218
 None
 1.17A 1tyrA-5gkfA:
undetectable		 1tyrA-5gkfA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5gkf ENDONUCLEASE ENDOMS
(Thermococcus
kodakarensis) 		4 / 4 ILE A 139
VAL A 177
VAL A 166
ARG A 155
 None
 1.21A 4m6tA-5gkfA:
undetectable		 4m6tA-5gkfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 5gkf ENDONUCLEASE ENDOMS
(Thermococcus
kodakarensis) 		5 / 12 VAL A  58
PHE A  64
ILE A  66
ILE A  33
VAL A  84
 None
 0.98A 5uvmB-5gkfA:
2.1		 5uvmB-5gkfA:
21.67