SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 11 LEU A 200
ILE A  91
GLU A 194
VAL A 106
PHE A 168
 None
 1.43A 1gx9A-5gkmA:
undetectable		 1gx9A-5gkmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 9 ASN A 218
LEU A 212
ALA A 208
LEU A 112
LEU A 200
 None
 1.22A 1hwiA-5gkmA:
undetectable		 1hwiA-5gkmA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		4 / 4 LEU A 212
SER A 128
LEU A 200
LEU A 112
 None
 1.17A 1yajA-5gkmA:
undetectable		 1yajA-5gkmA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 12 THR A 223
ALA A 197
LEU A 115
ARG A  86
LEU A 212
 None
 1.06A 2jfaA-5gkmA:
undetectable		 2jfaA-5gkmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 12 THR A 223
ALA A 197
LEU A 115
ARG A  86
LEU A 212
 None
 1.07A 2qxsA-5gkmA:
undetectable		 2qxsA-5gkmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 10 LEU A 212
ALA A 138
ILE A 132
SER A 128
LEU A 215
 None
 0.79A 3ogpA-5gkmA:
undetectable		 3ogpA-5gkmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 10 PHE A 176
PHE A  83
PHE A  80
ALA A  90
PHE A 168
 None
 1.46A 3t3qA-5gkmA:
undetectable		 3t3qA-5gkmA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 10 PHE A 176
PHE A  83
PHE A  80
ALA A  90
PHE A 168
 None
 1.46A 3t3qB-5gkmA:
undetectable		 3t3qB-5gkmA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 10 PHE A 176
PHE A  83
PHE A  80
ALA A  90
PHE A 168
 None
 1.45A 3t3qC-5gkmA:
undetectable		 3t3qC-5gkmA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 10 PHE A 176
PHE A  83
PHE A  80
ALA A  90
PHE A 168
 None
 1.44A 3t3qD-5gkmA:
undetectable		 3t3qD-5gkmA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 10 GLY A 114
ALA A 117
ILE A 132
LEU A 215
ILE A 130
 None
 0.98A 4dt8B-5gkmA:
undetectable		 4dt8B-5gkmA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5gkm AT5G51070/K3K7_27
(Arabidopsis
thaliana) 		5 / 12 THR A 223
ALA A 197
LEU A 115
ARG A  86
LEU A 212
 None
 1.13A 4xi3D-5gkmA:
undetectable		 4xi3D-5gkmA:
21.07