SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 292
LEU A 290
ILE A 362
GLY A 364
SER A 340
 None
 1.00A 1cqeA-5gkqA:
undetectable		 1cqeA-5gkqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 292
LEU A 290
ILE A 362
GLY A 364
SER A 340
 None
 1.00A 1cqeB-5gkqA:
undetectable		 1cqeB-5gkqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		6 / 11 ILE A 362
ALA A 327
ILE A 323
PHE A 325
ILE A 312
ILE A 365
 None
 1.35A 1dyrA-5gkqA:
undetectable		 1dyrA-5gkqA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 6 TYR A 206
ASP A 421
VAL A 423
GLY A 419
 None
 1.22A 1ekjC-5gkqA:
undetectable
1ekjD-5gkqA:
undetectable		 1ekjC-5gkqA:
16.62
1ekjD-5gkqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 6 ASP A 421
VAL A 423
GLY A 419
TYR A 206
 None
 1.18A 1ekjC-5gkqA:
undetectable
1ekjD-5gkqA:
undetectable		 1ekjC-5gkqA:
16.62
1ekjD-5gkqA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 292
LEU A 290
ILE A 362
GLY A 364
SER A 340
 None
 1.05A 1eqhB-5gkqA:
undetectable		 1eqhB-5gkqA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 PHE A 231
ILE A 273
ASN A 250
SER A 225
LEU A 238
 None
 1.22A 1fm4A-5gkqA:
undetectable		 1fm4A-5gkqA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 7 MET A 641
SER A 660
ALA A 623
ILE A 622
 None
 0.97A 1fxhA-5gkqA:
undetectable
1fxhB-5gkqA:
undetectable		 1fxhA-5gkqA:
14.87
1fxhB-5gkqA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 11 HIS A 563
PHE A 591
LEU A 661
ALA A 621
LEU A 618
 None
 1.30A 1mjlA-5gkqA:
undetectable
1mjlB-5gkqA:
undetectable		 1mjlA-5gkqA:
8.84
1mjlB-5gkqA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 6 THR A 150
ASN A 146
ASP A 124
TRP A 126
 None
 1.23A 1mxdA-5gkqA:
undetectable		 1mxdA-5gkqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 8 THR A 150
ASN A 146
ASP A 124
TRP A 126
 None
 1.20A 1mxgA-5gkqA:
undetectable		 1mxgA-5gkqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 9 PHE A 565
PHE A 553
VAL A 519
PHE A 564
LEU A 514
 None
 1.35A 1wrkA-5gkqA:
undetectable
1wrkB-5gkqA:
undetectable		 1wrkA-5gkqA:
8.31
1wrkB-5gkqA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 PHE A 207
ASN A 315
ILE A 216
ILE A 217
LEU A 278
 None
 1.18A 2bjfA-5gkqA:
undetectable		 2bjfA-5gkqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 9 LEU A 512
LEU A 478
LEU A 480
LEU A 465
ILE A 486
 None
 1.14A 2f78A-5gkqA:
undetectable		 2f78A-5gkqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 9 LEU A 512
LEU A 478
LEU A 480
LEU A 465
ILE A 486
 None
 1.14A 2f78B-5gkqA:
undetectable		 2f78B-5gkqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 9 LEU A 512
LEU A 478
LEU A 480
LEU A 465
ILE A 486
 None
 1.05A 2f7aA-5gkqA:
undetectable		 2f7aA-5gkqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 6 ARG A 627
GLY A 636
PRO A 691
LYS A 692
 None
 1.23A 2m2oB-5gkqA:
undetectable		 2m2oB-5gkqA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 ILE A 216
ILE A 217
ASN A 229
VAL A 202
VAL A 248
 None
 0.99A 2nnhA-5gkqA:
undetectable		 2nnhA-5gkqA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 LEU A 663
ALA A 659
GLY A 620
VAL A 625
ILE A 662
 None
 0.96A 2o4lA-5gkqA:
undetectable		 2o4lA-5gkqA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 9 LEU A 663
ALA A 659
GLY A 620
VAL A 625
ILE A 662
 None
 0.95A 2o4pB-5gkqA:
undetectable		 2o4pB-5gkqA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		6 / 12 GLY A 257
GLY A 236
GLY A 262
GLY A 283
THR A 237
LEU A 238
 None
 1.32A 2oxtB-5gkqA:
undetectable		 2oxtB-5gkqA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		3 / 3 ASP A 617
THR A 703
PRO A 704
 None
 0.37A 2q64B-5gkqA:
undetectable		 2q64B-5gkqA:
8.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 PHE A 207
ASN A 315
ILE A 216
ILE A 217
LEU A 278
 None
 1.13A 2rlcA-5gkqA:
undetectable		 2rlcA-5gkqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 LEU A 593
PHE A 565
ALA A 567
THR A 535
GLY A 510
 None
 1.05A 2ve3A-5gkqA:
undetectable		 2ve3A-5gkqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 ILE A 533
LEU A 593
ARG A 545
ILE A 610
THR A 535
 None
 0.96A 2w3bA-5gkqA:
undetectable		 2w3bA-5gkqA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 5 GLN A 406
ALA A 387
GLN A 374
ILE A 389
 None
 1.35A 2z0aA-5gkqA:
undetectable		 2z0aA-5gkqA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 GLY A 665
VAL A 605
LEU A 608
ILE A 682
PHE A 684
 None
 1.20A 3mnoA-5gkqA:
undetectable		 3mnoA-5gkqA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 GLY A 665
VAL A 605
LEU A 608
ILE A 682
PHE A 684
 None
 1.24A 3mnpA-5gkqA:
undetectable		 3mnpA-5gkqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 9 LEU A 663
ALA A 659
GLY A 620
VAL A 625
ILE A 662
 None
 0.95A 3oxvA-5gkqA:
undetectable		 3oxvA-5gkqA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		3 / 3 TYR A 428
ASP A  83
ASP A 113
 None
 0.83A 3r24A-5gkqA:
undetectable		 3r24A-5gkqA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 7 VAL A 129
LEU A 186
ASN A 205
ILE A 188
 None
 0.91A 3rfmA-5gkqA:
undetectable		 3rfmA-5gkqA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 10 PHE A 231
PHE A 207
ASN A 229
ILE A 226
THR A 200
 None
 1.34A 3t3rD-5gkqA:
undetectable		 3t3rD-5gkqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 GLY A 236
GLY A 283
HIS A 260
ARG A 175
SER A 234
 None
 1.34A 3tkaA-5gkqA:
undetectable		 3tkaA-5gkqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		3 / 3 ASP A 617
THR A 703
PRO A 704
 None
 0.49A 3tkgD-5gkqA:
undetectable		 3tkgD-5gkqA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		3 / 3 ARG A 393
ASP A 350
GLN A 351
 None
 0.66A 4azsA-5gkqA:
undetectable		 4azsA-5gkqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 ILE A 504
THR A 485
LEU A 546
VAL A 517
ILE A 486
 None
 1.05A 4c9lA-5gkqA:
undetectable		 4c9lA-5gkqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 ILE A 504
THR A 485
LEU A 546
VAL A 517
ILE A 486
 None
 1.05A 4c9lB-5gkqA:
undetectable		 4c9lB-5gkqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 ILE A 504
THR A 485
LEU A 546
VAL A 517
ILE A 486
 None
 1.04A 4c9oB-5gkqA:
undetectable		 4c9oB-5gkqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 8 ASP A 113
ASP A 574
ASP A 434
GLU A 432
 None
 1.07A 4gkhC-5gkqA:
undetectable
4gkhK-5gkqA:
undetectable		 4gkhC-5gkqA:
17.80
4gkhK-5gkqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 8 ASP A 113
ASP A 574
ASP A 434
GLU A 432
 None
 1.08A 4gkiE-5gkqA:
undetectable
4gkiG-5gkqA:
undetectable		 4gkiE-5gkqA:
17.80
4gkiG-5gkqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.04A 4hvcA-5gkqA:
undetectable		 4hvcA-5gkqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.10A 4hvcB-5gkqA:
undetectable		 4hvcB-5gkqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 LEU A  79
GLY A  78
THR A  50
ILE A  75
GLN A 109
 None
 1.24A 4o5fA-5gkqA:
undetectable
4o5fB-5gkqA:
undetectable		 4o5fA-5gkqA:
17.43
4o5fB-5gkqA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 GLN A 109
LEU A  79
GLY A  78
THR A  50
ILE A  75
 None
 1.25A 4o5fA-5gkqA:
undetectable
4o5fB-5gkqA:
undetectable		 4o5fA-5gkqA:
17.43
4o5fB-5gkqA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 ALA A 336
GLY A 295
ASP A 330
ILE A 338
GLY A 364
 None
 1.00A 4obwB-5gkqA:
undetectable		 4obwB-5gkqA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 11 LEU A 532
LEU A 546
ILE A 548
ILE A 496
PHE A 564
 None
 1.09A 4odrA-5gkqA:
undetectable
4odrB-5gkqA:
undetectable		 4odrA-5gkqA:
9.02
4odrB-5gkqA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.12A 4olfA-5gkqA:
undetectable		 4olfA-5gkqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 ASN A 229
PHE A 231
LEU A 238
ARG A 227
SER A 225
 None
 1.45A 4po0A-5gkqA:
undetectable		 4po0A-5gkqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.13A 4q15A-5gkqA:
undetectable		 4q15A-5gkqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.12A 4q15B-5gkqA:
undetectable		 4q15B-5gkqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		3 / 3 LYS A 653
ARG A 654
HIS A 560
 None
 1.21A 4zbrA-5gkqA:
undetectable		 4zbrA-5gkqA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.06A 5f9zA-5gkqA:
undetectable		 5f9zA-5gkqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.06A 5f9zB-5gkqA:
undetectable		 5f9zB-5gkqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 10 LEU A 532
VAL A 474
ILE A 486
LEU A 452
LEU A 546
 None
 1.13A 5ienB-5gkqA:
undetectable		 5ienB-5gkqA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 6 PRO A 691
GLU A 611
ALA A 623
LEU A 593
TYR A 607
 None
 1.46A 5igiA-5gkqA:
undetectable		 5igiA-5gkqA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		3 / 3 HIS A 138
ASP A 168
HIS A 169
 None
 0.91A 5n1tW-5gkqA:
undetectable		 5n1tW-5gkqA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 8 THR A 536
THR A 535
TYR A 544
PRO A 118
 None
 1.11A 5x2sI-5gkqA:
undetectable
5x2sJ-5gkqA:
undetectable
5x2sK-5gkqA:
undetectable		 5x2sI-5gkqA:
10.50
5x2sJ-5gkqA:
11.81
5x2sK-5gkqA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.03A 5xioA-5gkqA:
undetectable		 5xioA-5gkqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 0.99A 5xiqA-5gkqA:
undetectable		 5xiqA-5gkqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		5 / 12 VAL A 431
PRO A 429
TRP A 427
PHE A  60
GLY A  78
 None
 1.00A 5xiqD-5gkqA:
undetectable		 5xiqD-5gkqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		3 / 3 HIS A 169
HIS A 138
ARG A 135
 None
 1.10A 6b58A-5gkqA:
undetectable		 6b58A-5gkqA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 8 PHE A  81
VAL A  37
VAL A 107
VAL A  76
 None
 1.02A 6cp4A-5gkqA:
undetectable		 6cp4A-5gkqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 5gkq ALYGC MUTANT - R241A
(Paraglaciecola
chathamensis) 		4 / 5 GLN A 414
GLU A 416
ASN A 250
TYR A 400
 None
 1.46A 6iftA-5gkqA:
undetectable		 6iftA-5gkqA:
18.06