SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gkv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		4 / 7 GLY A 119
ALA A 227
HIS A 116
THR A 161
 None
 0.86A 1c9sT-5gkvA:
undetectable
1c9sU-5gkvA:
undetectable		 1c9sT-5gkvA:
9.87
1c9sU-5gkvA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.22A 1q23A-5gkvA:
undetectable
1q23B-5gkvA:
undetectable		 1q23A-5gkvA:
20.94
1q23B-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.18A 1q23B-5gkvA:
undetectable		 1q23B-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 10 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.26A 1q23E-5gkvA:
undetectable		 1q23E-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 11 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.20A 1q23G-5gkvA:
undetectable		 1q23G-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 11 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.25A 1q23I-5gkvA:
undetectable		 1q23I-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		4 / 8 MET A 311
TYR A 157
SER A  68
TYR A 319
 None
 1.29A 2bteA-5gkvA:
undetectable		 2bteA-5gkvA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 LEU A  77
PHE A 170
LEU A  76
ARG A 176
LEU A 274
 None
 1.31A 2qd4A-5gkvA:
undetectable		 2qd4A-5gkvA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 LEU A  77
PHE A 170
LEU A  76
ARG A 176
LEU A 274
 None
 1.33A 2qd4B-5gkvA:
undetectable		 2qd4B-5gkvA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 THR A 289
ALA A  79
PHE A 326
GLY A 266
PRO A 340
 None
 1.23A 2ve3B-5gkvA:
undetectable		 2ve3B-5gkvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		4 / 8 ALA A 356
TYR A 318
TYR A 302
HIS A 328
 None
 1.04A 2zm8A-5gkvA:
26.7		 2zm8A-5gkvA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		3 / 3 TRP A 244
VAL A  73
ARG A  80
 None
 0.94A 3b0wA-5gkvA:
undetectable		 3b0wA-5gkvA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		3 / 3 ARG A  52
LEU A  29
THR A  64
 None
 0.56A 3oxcA-5gkvA:
undetectable		 3oxcA-5gkvA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 VAL A   7
ARG A 205
ARG A  32
THR A 257
ALA A 256
 None
 1.05A 3sugA-5gkvA:
undetectable		 3sugA-5gkvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.32A 3u9fB-5gkvA:
undetectable
3u9fC-5gkvA:
undetectable		 3u9fB-5gkvA:
20.94
3u9fC-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 THR A  69
SER A 329
LEU A 300
VAL A 299
PHE A 229
 None
 1.31A 3u9fJ-5gkvA:
undetectable
3u9fL-5gkvA:
undetectable		 3u9fJ-5gkvA:
20.94
3u9fL-5gkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		4 / 8 GLU A 314
GLU A 303
GLY A 307
ARG A 312
 None
 0.97A 4fgzA-5gkvA:
undetectable
4fgzB-5gkvA:
undetectable		 4fgzA-5gkvA:
18.60
4fgzB-5gkvA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 9 TYR A 319
THR A  69
GLY A 330
LEU A  66
VAL A 349
 None
 1.31A 4mjrA-5gkvA:
0.4		 4mjrA-5gkvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 GLU A 324
ASP A 339
GLU A 291
GLY A 327
ILE A 367
 None
 1.19A 4xe5A-5gkvA:
undetectable		 4xe5A-5gkvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		4 / 6 ARG A 176
ARG A  86
ASP A 185
VAL A 173
 None
 1.26A 4xqeA-5gkvA:
undetectable		 4xqeA-5gkvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		4 / 6 ARG A 176
ARG A  86
ASP A 185
VAL A 173
 None
 1.28A 4xqeB-5gkvA:
undetectable		 4xqeB-5gkvA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 12 VAL A  43
ALA A 370
VAL A  15
GLY A 320
TYR A 319
 None
 1.00A 5igtA-5gkvA:
undetectable		 5igtA-5gkvA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5gkv ESTERASE A
(Caulobacter
vibrioides) 		5 / 10 VAL A  42
ILE A  37
GLY A 346
ALA A  34
PHE A  35
 None
 1.17A 5mxbA-5gkvA:
undetectable		 5mxbA-5gkvA:
13.24