SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_B_CUB4_0
(BETA-CARBONIC
ANHYDRASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 CYH A 438
CYH A 389
PRO A 442
SER A 440
 ZN  A 901 (-2.5A)
ZN  A 901 (-2.1A)
None
ZN  A 901 ( 4.0A)
 1.31A 1ekjA-5gl7A:
1.4
1ekjB-5gl7A:
1.5		 1ekjA-5gl7A:
15.85
1ekjB-5gl7A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.78A 1mt1A-5gl7A:
undetectable
1mt1F-5gl7A:
undetectable		 1mt1A-5gl7A:
8.70
1mt1F-5gl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ARG A 737
LEU A 681
ASP A 678
LEU A 674
 None
 0.79A 1mt1B-5gl7A:
undetectable
1mt1C-5gl7A:
undetectable		 1mt1B-5gl7A:
11.48
1mt1C-5gl7A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.81A 1mt1G-5gl7A:
undetectable
1mt1J-5gl7A:
undetectable		 1mt1G-5gl7A:
8.70
1mt1J-5gl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ARG A 737
LEU A 681
ASP A 678
LEU A 674
 None
 0.80A 1n13B-5gl7A:
undetectable
1n13C-5gl7A:
undetectable		 1n13B-5gl7A:
11.48
1n13C-5gl7A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ARG A 737
LEU A 681
ASP A 678
LEU A 674
 None
 0.84A 1n13H-5gl7A:
undetectable
1n13K-5gl7A:
undetectable		 1n13H-5gl7A:
11.48
1n13K-5gl7A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.83A 1n13G-5gl7A:
undetectable
1n13J-5gl7A:
undetectable		 1n13G-5gl7A:
8.70
1n13J-5gl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.83A 1n13I-5gl7A:
undetectable
1n13L-5gl7A:
undetectable		 1n13I-5gl7A:
8.70
1n13L-5gl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLU A 402
ASP A 416
ASP A 419
LEU A 430
GLY A 403
 None
 1.44A 1v8bC-5gl7A:
3.1		 1v8bC-5gl7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ASP A 605
ILE A 284
LEU A 281
HIS A 340
ILE A 339
 None
 1.17A 2dg9A-5gl7A:
undetectable		 2dg9A-5gl7A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ARG A 394
ASN A 276
PRO A 329
ALA A 322
 None
 1.32A 2ejfB-5gl7A:
undetectable		 2ejfB-5gl7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ARG A 394
ASN A 276
PRO A 329
ALA A 322
 None
 1.29A 2ejgA-5gl7A:
undetectable		 2ejgA-5gl7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ARG A 737
LEU A 681
ASP A 678
LEU A 674
 None
 0.79A 2qqcB-5gl7A:
undetectable
2qqcC-5gl7A:
undetectable		 2qqcB-5gl7A:
11.31
2qqcC-5gl7A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.80A 2qqcA-5gl7A:
undetectable
2qqcF-5gl7A:
undetectable		 2qqcA-5gl7A:
8.50
2qqcF-5gl7A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.78A 2qqcG-5gl7A:
undetectable
2qqcJ-5gl7A:
undetectable		 2qqcG-5gl7A:
8.50
2qqcJ-5gl7A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.78A 2qqcI-5gl7A:
undetectable
2qqcL-5gl7A:
undetectable		 2qqcI-5gl7A:
8.50
2qqcL-5gl7A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 681
ASP A 678
LEU A 674
ARG A 737
 None
 0.82A 2qqdA-5gl7A:
undetectable
2qqdE-5gl7A:
undetectable		 2qqdA-5gl7A:
8.50
2qqdE-5gl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 622
LEU A 621
ILE A 701
ARG A 702
 None
 0.95A 2rlfA-5gl7A:
undetectable
2rlfB-5gl7A:
undetectable		 2rlfA-5gl7A:
5.12
2rlfB-5gl7A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 622
LEU A 621
ILE A 701
ARG A 702
 None
 1.01A 2rlfC-5gl7A:
undetectable
2rlfD-5gl7A:
undetectable		 2rlfC-5gl7A:
5.12
2rlfD-5gl7A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ALA A 291
ILE A 349
TYR A 344
HIS A 340
 None
 0.93A 2zm8A-5gl7A:
undetectable		 2zm8A-5gl7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ALA A 291
ILE A 349
TYR A 344
HIS A 340
 None
 0.93A 2zmaA-5gl7A:
undetectable		 2zmaA-5gl7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 LEU A 499
THR A 316
THR A 496
HIS A 449
 None
 1.22A 3ce6B-5gl7A:
3.0		 3ce6B-5gl7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ASN A 542
ILE A 528
GLY A 524
LEU A 306
THR A 269
 None
 1.07A 3eeyH-5gl7A:
2.3		 3eeyH-5gl7A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A 708
TYR A 692
LEU A 756
VAL A 763
ALA A 614
 None
 1.29A 3ozuA-5gl7A:
2.6		 3ozuA-5gl7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ILE A 343
TYR A 344
ASP A 312
THR A 269
 None
 1.00A 3q70A-5gl7A:
undetectable		 3q70A-5gl7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 4 PHE A 551
TYR A 297
ILE A 624
LEU A 621
 None
 1.32A 3sudA-5gl7A:
undetectable		 3sudA-5gl7A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 PHE A 551
TYR A 297
ILE A 624
LEU A 621
 None
 1.28A 3sueC-5gl7A:
undetectable		 3sueC-5gl7A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.42A 3wg7A-5gl7A:
1.6
3wg7B-5gl7A:
undetectable
3wg7T-5gl7A:
undetectable		 3wg7A-5gl7A:
20.77
3wg7B-5gl7A:
16.40
3wg7T-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PRO A 758
LEU A 696
LEU A 689
ILE A 708
PHE A 785
 None
 1.24A 4a79A-5gl7A:
undetectable		 4a79A-5gl7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 TYR A 759
VAL A 699
TYR A 692
TYR A 297
 None
 1.31A 4bqtC-5gl7A:
undetectable
4bqtD-5gl7A:
undetectable		 4bqtC-5gl7A:
17.03
4bqtD-5gl7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 VAL A 293
LEU A 695
TYR A 692
VAL A 699
LEU A 622
 None
 1.14A 4coxA-5gl7A:
undetectable		 4coxA-5gl7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 VAL A 293
LEU A 695
TYR A 692
VAL A 699
LEU A 622
 None
 1.15A 4coxB-5gl7A:
undetectable		 4coxB-5gl7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 VAL A 293
LEU A 695
TYR A 692
VAL A 699
LEU A 622
 None
 1.15A 4coxD-5gl7A:
undetectable		 4coxD-5gl7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 366
ALA A 521
THR A 522
THR A 357
 None
 1.01A 4qw0K-5gl7A:
undetectable		 4qw0K-5gl7A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 366
ALA A 521
THR A 522
THR A 357
 None
 1.01A 4qw0Y-5gl7A:
undetectable		 4qw0Y-5gl7A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 GLU A 313
TYR A 274
ILE A 332
THR A 318
 None
 1.32A 4qwpB-5gl7A:
undetectable		 4qwpB-5gl7A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 LEU A 786
LEU A 689
LEU A 782
VAL A 754
ILE A 780
 None
 1.05A 4x20D-5gl7A:
undetectable		 4x20D-5gl7A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ALA A 291
LEU A 289
ARG A 299
ILE A 528
GLY A 310
 None
 0.99A 4xi3B-5gl7A:
undetectable		 4xi3B-5gl7A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.44A 5b1aA-5gl7A:
1.6
5b1aB-5gl7A:
undetectable
5b1aT-5gl7A:
undetectable		 5b1aA-5gl7A:
20.77
5b1aB-5gl7A:
16.40
5b1aT-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.45A 5b1bA-5gl7A:
1.9
5b1bB-5gl7A:
undetectable
5b1bT-5gl7A:
undetectable		 5b1bA-5gl7A:
20.77
5b1bB-5gl7A:
16.40
5b1bT-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.46A 5b3sA-5gl7A:
1.3
5b3sB-5gl7A:
undetectable
5b3sT-5gl7A:
undetectable		 5b3sA-5gl7A:
20.77
5b3sB-5gl7A:
16.40
5b3sT-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 HIS A 793
LEU A 773
CYH A 787
LEU A 244
 None
 1.50A 5hrqD-5gl7A:
undetectable
5hrqG-5gl7A:
undetectable
5hrqH-5gl7A:
undetectable		 5hrqD-5gl7A:
3.79
5hrqG-5gl7A:
4.15
5hrqH-5gl7A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 10 PRO A 433
ILE A 425
VAL A 401
LEU A 396
ASP A 416
 None
 1.40A 5tixB-5gl7A:
undetectable		 5tixB-5gl7A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.47A 5x19A-5gl7A:
1.7
5x19B-5gl7A:
undetectable
5x19T-5gl7A:
undetectable		 5x19A-5gl7A:
20.77
5x19B-5gl7A:
16.40
5x19T-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.47A 5xdqA-5gl7A:
0.2
5xdqB-5gl7A:
undetectable
5xdqT-5gl7A:
undetectable		 5xdqA-5gl7A:
20.77
5xdqB-5gl7A:
16.40
5xdqT-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ALA A 571
GLN A 372
LYS A 375
GLN A 371
 None
 1.16A 5y9aA-5gl7A:
2.5		 5y9aA-5gl7A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.45A 5z84A-5gl7A:
1.4
5z84B-5gl7A:
undetectable
5z84T-5gl7A:
undetectable		 5z84A-5gl7A:
20.77
5z84B-5gl7A:
16.40
5z84T-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.46A 5z86A-5gl7A:
1.6
5z86B-5gl7A:
undetectable
5z86T-5gl7A:
undetectable		 5z86A-5gl7A:
20.77
5z86B-5gl7A:
16.40
5z86T-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.43A 5zcoA-5gl7A:
0.2
5zcoB-5gl7A:
undetectable
5zcoT-5gl7A:
undetectable		 5zcoA-5gl7A:
20.77
5zcoB-5gl7A:
16.40
5zcoT-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.46A 5zcpA-5gl7A:
0.2
5zcpB-5gl7A:
undetectable
5zcpT-5gl7A:
undetectable		 5zcpA-5gl7A:
20.77
5zcpB-5gl7A:
16.40
5zcpT-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.45A 5zcqA-5gl7A:
0.2
5zcqB-5gl7A:
undetectable
5zcqT-5gl7A:
undetectable		 5zcqA-5gl7A:
20.77
5zcqB-5gl7A:
16.40
5zcqT-5gl7A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 GLY A 355
THR A 311
GLU A 313
 None
 0.57A 6b58A-5gl7A:
5.3		 6b58A-5gl7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 THR A 359
GLN A 362
THR A 503
VAL A 514
VAL A 505
 None
 1.35A 6bzoC-5gl7A:
undetectable		 6bzoC-5gl7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 10 GLY A 667
GLY A 666
ILE A 795
THR A 797
GLY A 658
 None
 1.02A 6e5zA-5gl7A:
undetectable		 6e5zA-5gl7A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 MET A 659
GLY A 658
GLN A 770
THR A 766
GLY A 651
 None
 1.46A 6nmpA-5gl7A:
0.6
6nmpB-5gl7A:
0.0
6nmpT-5gl7A:
0.0		 6nmpA-5gl7A:
20.77
6nmpB-5gl7A:
16.40
6nmpT-5gl7A:
8.85