SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 10 LEU A  57
ALA A 176
ASP A 177
GLY A 172
ILE A 171
 None
 1.07A 1d4yA-5gleA:
undetectable		 1d4yA-5gleA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 6 PRO A 168
PHE A 169
GLN A 142
VAL A  33
 None
 1.22A 1l2iB-5gleA:
undetectable		 1l2iB-5gleA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 9 THR A  64
LEU A  38
VAL A  35
VAL A 200
VAL A  63
 None
 1.34A 1t86B-5gleA:
undetectable		 1t86B-5gleA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 7 ALA A 176
ASP A 177
GLY A 172
ILE A 171
 None
 0.80A 2fxdB-5gleA:
undetectable		 2fxdB-5gleA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 LEU A  57
ALA A 176
ASP A 177
GLY A 172
ILE A 171
 None
 1.07A 2o4kA-5gleA:
undetectable		 2o4kA-5gleA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 11 LEU A  57
ALA A 176
ASP A 177
GLY A 172
ILE A 171
 None
 1.09A 2o4pA-5gleA:
undetectable		 2o4pA-5gleA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 10 ALA A 176
LEU A  43
LEU A  57
VAL A  60
ILE A 105
 None
 0.80A 2w9gA-5gleA:
undetectable		 2w9gA-5gleA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 10 ALA A 176
LEU A  43
LEU A  57
VAL A  60
ILE A 105
 None
 0.99A 2w9hA-5gleA:
undetectable		 2w9hA-5gleA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 8 ILE A 152
TRP A  95
PHE A  94
TYR A 123
 None
 1.28A 3ccfB-5gleA:
3.1		 3ccfB-5gleA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 8 ALA A 176
ASP A 177
GLY A 172
ILE A 171
 None
 0.71A 3el9A-5gleA:
undetectable		 3el9A-5gleA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 11 ALA A 176
LEU A  43
LEU A  57
VAL A  60
ILE A 105
 None
 0.83A 3frbX-5gleA:
undetectable		 3frbX-5gleA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 9 ALA A 176
LEU A  43
LEU A  57
VAL A  60
ILE A 105
 None
 0.85A 3freX-5gleA:
undetectable		 3freX-5gleA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 9 LEU A  57
ALA A 176
ASP A 177
GLY A 172
ILE A 171
 None
 1.08A 3gguB-5gleA:
undetectable		 3gguB-5gleA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 11 ASP A  37
PHE A  42
TRP A  95
LYS A 120
TYR A 123
 None
 0.91A 3r2jB-5gleA:
19.0		 3r2jB-5gleA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 12 ASP A  37
PHE A  42
TRP A  95
LYS A 120
TYR A 123
 None
 0.90A 3r2jC-5gleA:
19.2		 3r2jC-5gleA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 11 ASP A  37
PHE A  42
TRP A  95
LYS A 120
TYR A 123
 None
 0.86A 3r2jD-5gleA:
19.0		 3r2jD-5gleA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 9 LEU A  57
ALA A 176
ASP A 177
GLY A 172
ILE A 171
 None
 1.06A 4dqcB-5gleA:
undetectable		 4dqcB-5gleA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 9 THR A  64
LEU A  38
VAL A  35
VAL A 200
VAL A  63
 None
 1.33A 4ek1B-5gleA:
undetectable		 4ek1B-5gleA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		5 / 9 THR A  64
LEU A  38
VAL A  35
VAL A 200
VAL A  63
 None
 1.39A 5cp4A-5gleA:
undetectable		 5cp4A-5gleA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5gle ISCHORISMATE LYASE
(Vibrio
anguillarum) 		4 / 7 PHE A 169
ASP A  27
LYS A  30
SER A 206
 None
 1.41A 5nr3A-5gleA:
undetectable		 5nr3A-5gleA:
18.02