SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5glg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 HIS A 435
LEU A 146
LEU A 121
GLY A 480
SIN  A 601 ( 4.1A)
None
None
FAD  A 602 ( 3.2A)
1.11A 1a4lB-5glgA:
undetectable
1a4lB-5glgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
3 / 3 THR A 283
PRO A 432
THR A 431
None
0.87A 1dscC-5glgA:
undetectable
1dscC-5glgA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
3 / 3 THR A 431
THR A 283
PRO A 432
None
0.80A 1dscC-5glgA:
undetectable
1dscC-5glgA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 8 TYR A 501
PHE A 463
THR A  49
LEU A  53
None
1.18A 1ea1A-5glgA:
undetectable
1ea1A-5glgA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 THR A  49
GLY A  46
ILE A 462
LEU A 458
VAL A 457
None
1.16A 1r30A-5glgA:
undetectable
1r30A-5glgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 THR A  49
GLY A  46
ILE A 462
LEU A 458
VAL A 457
None
1.16A 1r30B-5glgA:
undetectable
1r30B-5glgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 PRO A 115
GLY A 474
GLY A 113
ASP A 327
SER A 108
None
1.18A 1wg8B-5glgA:
2.8
1wg8B-5glgA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 LEU A 346
GLY A 307
GLY A 305
LEU A 146
GLY A 147
None
1.18A 1y4lA-5glgA:
undetectable
1y4lA-5glgA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 11 LEU A 140
LEU A 132
SER A 172
LEU A 171
LEU A 138
None
1.10A 2ceoA-5glgA:
undetectable
2ceoA-5glgA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 6 GLN A 334
ASN A 342
ASN A 253
LEU A 298
None
None
FAD  A 602 (-4.6A)
FAD  A 602 ( 3.8A)
1.28A 2nyrA-5glgA:
2.7
2nyrA-5glgA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 LEU A 175
ILE A  70
SER A  42
GLY A  46
None
None
FAD  A 602 ( 4.0A)
None
0.83A 2otfA-5glgA:
undetectable
2otfA-5glgA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 11 LEU A 268
VAL A 441
GLN A 262
ILE A 197
ALA A 464
None
1.19A 2q72A-5glgA:
undetectable
2q72A-5glgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 LEU A 265
ILE A  40
LEU A  64
ILE A 264
VAL A 205
None
FAD  A 602 (-4.8A)
None
None
None
1.11A 2ygpA-5glgA:
undetectable
2ygpA-5glgA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 6 GLY A 440
GLY A 470
GLY A 471
GLY A 439
GLY A 474
None
1.18A 3bogA-5glgA:
undetectable
3bogC-5glgA:
undetectable
3bogA-5glgA:
undetectable
3bogC-5glgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 GLY A 261
GLY A 259
GLY A 231
ASP A 196
LEU A 265
None
1.06A 3ihtA-5glgA:
2.4
3ihtA-5glgA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 ILE A  40
GLY A  41
ASP A  65
ALA A  67
ALA A  45
FAD  A 602 (-4.8A)
FAD  A 602 (-3.2A)
FAD  A 602 (-2.7A)
FAD  A 602 ( 3.7A)
FAD  A 602 (-3.4A)
0.97A 3jb1A-5glgA:
undetectable
3jb1A-5glgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 GLY A  46
ARG A  52
ALA A 494
ALA A 493
ASP A 495
None
1.08A 3keeA-5glgA:
undetectable
3keeA-5glgA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 GLY A  46
ARG A  52
ALA A 494
ALA A 493
ASP A 495
None
1.10A 3keeD-5glgA:
undetectable
3keeD-5glgA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 GLN A 262
PHE A 436
GLY A 470
GLY A 474
GLY A 440
None
1.14A 3tegA-5glgA:
undetectable
3tegA-5glgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 ILE A 462
ALA A 464
ILE A  40
ALA A 493
VAL A 208
None
None
FAD  A 602 (-4.8A)
None
None
0.93A 4k6iA-5glgA:
undetectable
4k6iA-5glgA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 ILE A 188
LEU A 175
GLY A  71
SER A  74
ASN A 253
None
None
None
FAD  A 602 (-2.6A)
FAD  A 602 (-4.6A)
1.20A 4o1eA-5glgA:
undetectable
4o1eA-5glgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 SER A 481
GLY A 479
ARG A 153
PHE A 101
None
SIN  A 601 (-3.6A)
None
None
1.26A 4r82A-5glgA:
undetectable
4r82B-5glgA:
undetectable
4r82A-5glgA:
16.34
4r82B-5glgA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 HIS A 281
THR A 283
GLU A 301
GLY A 147
GLY A  80
SIN  A 601 (-4.3A)
None
None
None
FAD  A 602 (-3.9A)
1.38A 4uinH-5glgA:
undetectable
4uinL-5glgA:
undetectable
4uinH-5glgA:
19.91
4uinL-5glgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 10 GLY A 113
VAL A 114
THR A 105
LEU A 106
SER A 116
None
1.25A 4yb6B-5glgA:
undetectable
4yb6C-5glgA:
undetectable
4yb6B-5glgA:
22.08
4yb6C-5glgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 10 LEU A 106
SER A 116
GLY A 113
VAL A 114
THR A 105
None
1.24A 4yb6D-5glgA:
undetectable
4yb6E-5glgA:
undetectable
4yb6D-5glgA:
22.08
4yb6E-5glgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 10 LEU A 106
SER A 116
GLY A 113
VAL A 114
THR A 105
None
1.27A 4yb6B-5glgA:
undetectable
4yb6F-5glgA:
undetectable
4yb6B-5glgA:
22.08
4yb6F-5glgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 7 GLY A  80
ARG A 477
GLY A 479
ALA A  77
FAD  A 602 (-3.9A)
SIN  A 601 ( 2.9A)
SIN  A 601 (-3.6A)
FAD  A 602 (-3.2A)
0.95A 5e26A-5glgA:
undetectable
5e26B-5glgA:
undetectable
5e26A-5glgA:
21.33
5e26B-5glgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 GLY A 480
LEU A 484
GLY A  83
ASP A  96
LEU A 146
FAD  A 602 ( 3.2A)
None
None
None
None
1.10A 5hg0A-5glgA:
undetectable
5hg0A-5glgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 GLY A 480
LEU A 484
GLY A  83
ASP A  96
LEU A 146
FAD  A 602 ( 3.2A)
None
None
None
None
1.05A 5hg0B-5glgA:
undetectable
5hg0B-5glgA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 GLY A 148
THR A 325
GLY A 159
LEU A 306
None
0.90A 5jlcA-5glgA:
undetectable
5jlcA-5glgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 8 ILE A 333
ALA A 344
PHE A 319
PRO A 409
None
0.87A 5m0oC-5glgA:
undetectable
5m0oC-5glgA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
3 / 3 GLY A 254
THR A 252
ASN A  73
None
FAD  A 602 (-4.1A)
FAD  A 602 (-4.2A)
0.70A 5odiG-5glgA:
13.2
5odiG-5glgA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 7 VAL A 468
VAL A 441
ILE A 264
ASP A 260
None
None
None
FAD  A 602 (-3.9A)
0.89A 5yf9B-5glgA:
undetectable
5yf9B-5glgA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
3 / 3 HIS A 281
HIS A 435
ARG A 477
SIN  A 601 (-4.3A)
SIN  A 601 ( 4.1A)
SIN  A 601 ( 2.9A)
0.52A 6b58A-5glgA:
30.4
6b58A-5glgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 LEU A 368
THR A 252
PRO A 162
ARG A 156
None
FAD  A 602 (-4.1A)
None
None
1.39A 6ew0B-5glgA:
undetectable
6ew0B-5glgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 LEU A 368
THR A 252
PRO A 162
ARG A 156
None
FAD  A 602 (-4.1A)
None
None
1.39A 6ew0D-5glgA:
undetectable
6ew0D-5glgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 LEU A 368
THR A 252
PRO A 162
ARG A 156
None
FAD  A 602 (-4.1A)
None
None
1.39A 6ew0H-5glgA:
undetectable
6ew0H-5glgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 5 LEU A 368
THR A 252
PRO A 162
ARG A 156
None
FAD  A 602 (-4.1A)
None
None
1.39A 6ew0I-5glgA:
undetectable
6ew0I-5glgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
4 / 6 LEU A 146
THR A 154
GLY A 480
ARG A 477
None
None
FAD  A 602 ( 3.2A)
SIN  A 601 ( 2.9A)
1.37A 6gtqB-5glgA:
undetectable
6gtqD-5glgA:
undetectable
6gtqB-5glgA:
19.57
6gtqD-5glgA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 VAL A  37
THR A 492
ASP A 495
SER A 127
TYR A  57
None
1.46A 6h7lA-5glgA:
undetectable
6h7lA-5glgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)
5glg FUMARATE REDUCTASE 2
(Saccharomyces
cerevisiae)
5 / 12 VAL A  37
THR A 492
ASP A 495
SER A 127
TYR A  57
None
1.47A 6h7lB-5glgA:
undetectable
6h7lB-5glgA:
11.26