SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 6 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 1.03A 2e1qA-5gliA:
undetectable		 2e1qA-5gliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 6 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 1.03A 2e1qC-5gliA:
undetectable		 2e1qC-5gliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		5 / 12 LEU A 315
MET A1006
THR A1109
THR A1112
GLY A1113
 None
 0.96A 2uvnA-5gliA:
undetectable		 2uvnA-5gliA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		3 / 3 PRO A 259
LEU A 257
GLN A 261
 None
 0.64A 3hznG-5gliA:
undetectable
3hznH-5gliA:
undetectable		 3hznG-5gliA:
18.81
3hznH-5gliA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 5 TYR A 102
THR A  99
PHE A 100
LEU A 162
 None
 1.43A 3qelC-5gliA:
undetectable		 3qelC-5gliA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 7 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 1.01A 3uniA-5gliA:
undetectable		 3uniA-5gliA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 8 GLY A1113
THR A1114
THR A1108
ARG A1111
 None
 0.96A 4k87A-5gliA:
undetectable		 4k87A-5gliA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		3 / 3 GLU A 236
ALA A 237
PHE A 240
 None
 0.26A 4v1fA-5gliA:
undetectable		 4v1fA-5gliA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		3 / 3 GLU A 236
ALA A 237
PHE A 240
 None
 0.23A 4v1fC-5gliA:
undetectable		 4v1fC-5gliA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 6 GLU A 236
PHE A 268
THR A 271
TYR A 269
 None
None
OLC  A1206 (-4.8A)
None
 1.23A 5lrbA-5gliA:
undetectable		 5lrbA-5gliA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		4 / 6 GLU A 236
PHE A 268
TYR A 269
TYR A 281
 None
 1.29A 5lrbA-5gliA:
undetectable		 5lrbA-5gliA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		7 / 12 VAL A 185
LYS A 273
TRP A 336
LEU A 339
ARG A 343
ILE A 372
ALA A 375
 None
 0.93A 5xprA-5gliA:
44.1		 5xprA-5gliA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 5gli ENDOTHELIN RECEPTOR
SUBTYPE-B
(Homo
sapiens) 		7 / 12 VAL A 185
LYS A 273
TRP A 336
LEU A 339
HIS A 340
ILE A 372
ALA A 375
 None
 0.79A 5xprA-5gliA:
44.1		 5xprA-5gliA:
99.78