SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5glj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 5 LEU A1104
GLU A1169
ALA A1167
LEU A1164
 None
 1.15A 1eta1-5gljA:
undetectable		 1eta1-5gljA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		4 / 5 LEU A1104
GLU A1169
ALA A1167
LEU A1164
 None
 1.13A 1eta2-5gljA:
undetectable		 1eta2-5gljA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 10 LEU A1164
ALA A1159
GLY A1154
VAL A1147
ILE A1163
 None
 0.95A 1hsgA-5gljA:
undetectable		 1hsgA-5gljA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 11 LEU A1173
ALA A1167
VAL A1150
ILE A1161
VAL A1147
 None
 0.76A 2nnpB-5gljA:
undetectable		 2nnpB-5gljA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 9 LEU A1164
ALA A1159
GLY A1154
VAL A1147
ILE A1163
 None
 1.01A 2o4pB-5gljA:
undetectable		 2o4pB-5gljA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 LEU A1173
ALA A1167
VAL A1150
ILE A1161
VAL A1147
 None
 0.89A 3gguA-5gljA:
undetectable		 3gguA-5gljA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 HIS A1157
LEU A1164
ILE A1123
SER A1125
LEU A1173
 None
None
None
CL  A1202 (-3.0A)
None
 1.02A 3nrrB-5gljA:
undetectable		 3nrrB-5gljA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 10 LEU A1173
ALA A1167
VAL A1150
ILE A1161
VAL A1147
 None
 0.85A 3nu9B-5gljA:
undetectable		 3nu9B-5gljA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 VAL A1126
LEU A1164
ILE A1123
LEU A1173
LEU A1096
 CL  A1201 (-4.7A)
None
None
None
None
 0.95A 4p65B-5gljA:
undetectable
4p65D-5gljA:
undetectable
4p65I-5gljA:
undetectable
4p65J-5gljA:
undetectable		 4p65B-5gljA:
14.44
4p65D-5gljA:
14.44
4p65I-5gljA:
10.34
4p65J-5gljA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5glj TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 13
(Homo
sapiens) 		5 / 12 LEU A1164
VAL A1126
ILE A1123
LEU A1173
LEU A1096
 None
CL  A1201 (-4.7A)
None
None
None
 0.95A 4p65F-5gljA:
undetectable
4p65H-5gljA:
undetectable
4p65K-5gljA:
undetectable
4p65L-5gljA:
undetectable		 4p65F-5gljA:
14.44
4p65H-5gljA:
14.44
4p65K-5gljA:
10.34
4p65L-5gljA:
14.44