SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 6 ILE A 176
GLU A 268
ASP A  57
PRO A 127
 None
ACT  A 405 ( 3.8A)
GOL  A 403 (-2.9A)
None
 1.21A 1ditH-5gllA:
undetectable
1ditP-5gllA:
undetectable		 1ditH-5gllA:
22.87
1ditP-5gllA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		5 / 7 GLY A 286
ASP A  57
SER A 284
HIS A 319
ALA A 126
 None
GOL  A 403 (-2.9A)
None
CA  A 401 (-3.8A)
GOL  A 403 (-3.2A)
 1.34A 1gxsA-5gllA:
undetectable
1gxsB-5gllA:
undetectable		 1gxsA-5gllA:
20.74
1gxsB-5gllA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 7 TYR A 367
ASN A 318
TYR A 290
GLY A 286
 None
 1.33A 1mxgA-5gllA:
undetectable		 1mxgA-5gllA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 8 ASP A  74
PHE A  88
SER A 339
ALA A  77
 None
GOL  A 403 ( 3.7A)
None
None
 1.14A 1rqpA-5gllA:
undetectable		 1rqpA-5gllA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 7 ARG A 346
HIS A  87
ASP A  57
GLY A  85
 GOL  A 403 (-2.7A)
GOL  A 404 (-4.4A)
GOL  A 403 (-2.9A)
ACT  A 405 ( 4.2A)
 1.03A 2f6dA-5gllA:
undetectable		 2f6dA-5gllA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		5 / 12 TYR A  93
PHE A 140
LEU A 138
ILE A 151
ALA A 269
 None
None
None
None
CA  A 401 ( 4.9A)
 1.19A 2g72B-5gllA:
undetectable		 2g72B-5gllA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 8 ASP A  74
PHE A  88
SER A 339
ALA A  77
 None
GOL  A 403 ( 3.7A)
None
None
 1.13A 2v7uA-5gllA:
undetectable		 2v7uA-5gllA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		5 / 12 ALA A 269
ILE A 176
ILE A 322
ALA A  60
ASP A  57
 CA  A 401 ( 4.9A)
None
None
None
GOL  A 403 (-2.9A)
 1.15A 3axtA-5gllA:
undetectable		 3axtA-5gllA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 8 ARG A 346
ILE A 348
PRO A  58
PRO A  71
 GOL  A 403 (-2.7A)
None
None
None
 0.99A 3fxrA-5gllA:
undetectable		 3fxrA-5gllA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 8 GLY A 197
PHE A 240
GLY A 193
PHE A 192
 ACT  A 405 (-3.4A)
None
None
None
 0.92A 3ko0O-5gllA:
undetectable
3ko0Q-5gllA:
undetectable		 3ko0O-5gllA:
10.47
3ko0Q-5gllA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 5 HIS A 334
SER A  72
ARG A 122
THR A 317
 None
GOL  A 403 ( 4.5A)
None
GOL  A 403 (-4.0A)
 1.25A 3okxA-5gllA:
undetectable		 3okxA-5gllA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 5 HIS A 334
SER A  72
ARG A 122
THR A 317
 None
GOL  A 403 ( 4.5A)
None
GOL  A 403 (-4.0A)
 1.22A 3okxB-5gllA:
undetectable		 3okxB-5gllA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 7 PRO A  48
ARG A  42
GLY A 103
PRO A 102
 None
 1.34A 3ucbB-5gllA:
undetectable		 3ucbB-5gllA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		3 / 3 PHE A 181
TYR A 300
TYR A 191
 None
 1.09A 4ffwA-5gllA:
undetectable		 4ffwA-5gllA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 7 ASP A 128
SER A 321
HIS A  61
SER A  59
 None
None
None
CA  A 401 ( 3.7A)
 1.15A 4k7gB-5gllA:
undetectable		 4k7gB-5gllA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		3 / 3 ASP A  64
SER A 131
TYR A 136
 ACT  A 406 (-4.6A)
ACT  A 406 (-3.0A)
ACT  A 406 (-4.8A)
 0.10A 5glmA-5gllA:
62.5		 5glmA-5gllA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 6 LYS A 143
ARG A 122
GLY A  85
ASP A  86
 None
None
ACT  A 405 ( 4.2A)
None
 1.33A 5hp1A-5gllA:
undetectable		 5hp1A-5gllA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		3 / 3 TRP A 196
MET A  84
ASN A  82
 None
 1.37A 5uc1B-5gllA:
undetectable		 5uc1B-5gllA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		3 / 3 TRP A 196
MET A  84
ASN A  82
 None
 1.40A 5uc1A-5gllA:
undetectable		 5uc1A-5gllA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5gll GLYCOSIDE HYDROLASE
FAMILY 43
(uncultured
bacterium) 		4 / 7 PHE A 332
LEU A  49
GLY A 103
GLY A  65
 None
 0.74A 6eu9D-5gllA:
undetectable		 6eu9D-5gllA:
14.33