SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gm2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		4 / 5 LEU A  32
VAL A  27
TYR A  28
THR A  31
 None
 1.34A 1nw3A-5gm2A:
10.6		 1nw3A-5gm2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 ILE A  84
GLY A  87
ILE A 152
VAL A 108
SER A 109
 None
SAH  A 301 (-3.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
None
 1.16A 1sg9A-5gm2A:
11.3		 1sg9A-5gm2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		6 / 12 ILE A  84
GLY A  85
GLY A  87
ILE A 152
VAL A 108
SER A 109
 None
SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.2A)
None
 1.10A 1sg9B-5gm2A:
11.0		 1sg9B-5gm2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		6 / 12 GLY A  87
SER A 109
ALA A 136
ILE A 152
SER A 154
HIS A 157
 SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.3A)
 0.80A 1ve3A-5gm2A:
18.6		 1ve3A-5gm2A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		6 / 12 GLY A  87
SER A 109
ALA A 136
ILE A 152
SER A 154
HIS A 157
 SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.1A)
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.3A)
 0.65A 1ve3B-5gm2A:
18.4		 1ve3B-5gm2A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		4 / 5 SER A 154
LEU A 178
LEU A 177
LEU A  69
 SAH  A 301 (-4.4A)
None
None
None
 1.08A 1yajD-5gm2A:
undetectable		 1yajD-5gm2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 ILE A  84
GLY A  85
GLY A  87
ILE A 152
HIS A 157
 None
SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.1A)
SAH  A 301 ( 4.3A)
 0.50A 2fk8A-5gm2A:
24.8		 2fk8A-5gm2A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  85
GLY A  87
THR A  91
ALA A 136
HIS A 157
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.3A)
 0.86A 2gluA-5gm2A:
21.3		 2gluA-5gm2A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  85
GLY A  87
THR A  91
ALA A 136
HIS A 157
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.3A)
 1.00A 2gluB-5gm2A:
21.0		 2gluB-5gm2A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		4 / 8 THR A 235
VAL A 238
VAL A  55
ARG A  64
 TEX  A 302 ( 4.6A)
None
None
None
 0.89A 2ij7C-5gm2A:
undetectable		 2ij7C-5gm2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 11 GLY A  85
GLY A  87
VAL A 108
ASP A 135
ALA A 136
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
 0.73A 3dxyA-5gm2A:
11.8		 3dxyA-5gm2A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  85
THR A  91
SER A 109
ASP A 135
ALA A 136
 SAH  A 301 (-3.2A)
SAH  A 301 (-4.2A)
None
SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
 0.56A 3id6C-5gm2A:
12.5		 3id6C-5gm2A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  85
GLY A  87
GLY A  89
THR A  91
ASP A 135
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
None
SAH  A 301 (-4.2A)
SAH  A 301 (-3.6A)
 0.96A 3ihtA-5gm2A:
8.8		 3ihtA-5gm2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  87
SER A 109
ASP A 135
SER A 154
HIS A 157
 SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.3A)
 0.86A 3pfgA-5gm2A:
16.2		 3pfgA-5gm2A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 THR A  72
LEU A 284
VAL A 215
PHE A 211
VAL A 179
 None
 1.47A 3u9fH-5gm2A:
undetectable
3u9fI-5gm2A:
undetectable		 3u9fH-5gm2A:
20.32
3u9fI-5gm2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  85
GLY A  87
VAL A 106
GLN A 112
SER A 154
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
None
SAH  A 301 (-2.6A)
SAH  A 301 (-4.4A)
 0.40A 4f84A-5gm2A:
25.8		 4f84A-5gm2A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		4 / 7 GLY A  87
ILE A 113
ASN A 117
GLN A  62
 SAH  A 301 (-3.1A)
None
None
None
 0.93A 4g0vA-5gm2A:
undetectable		 4g0vA-5gm2A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  85
GLY A  87
ASP A 135
SER A 154
HIS A 157
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.3A)
 0.81A 4iv0B-5gm2A:
23.3		 4iv0B-5gm2A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		6 / 12 GLY A  85
GLY A  87
SER A 109
ASP A 135
ALA A 136
HIS A 157
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.6A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.3A)
 0.63A 4krhA-5gm2A:
24.1		 4krhA-5gm2A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  85
GLY A  87
SER A 109
ALA A 136
HIS A 157
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.3A)
 0.55A 4krhB-5gm2A:
24.3		 4krhB-5gm2A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 LEU A 171
ALA A 136
MET A 158
LEU A 164
PHE A 220
 None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
None
None
 1.04A 4qdcA-5gm2A:
undetectable		 4qdcA-5gm2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLU A 144
LEU A 177
GLY A 165
ALA A 163
ILE A  84
 None
 1.25A 4xe5A-5gm2A:
undetectable		 4xe5A-5gm2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		5 / 12 GLY A  87
SER A 109
ASP A 135
SER A 154
HIS A 157
 SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.3A)
 1.25A 5hikA-5gm2A:
17.0		 5hikA-5gm2A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5gm2 O-METHYLRANSFERASE
(Streptomyces
blastmyceticus) 		3 / 3 THR A  91
THR A  72
LEU A 228
 SAH  A 301 (-4.2A)
None
None
 0.69A 5m66D-5gm2A:
2.3		 5m66D-5gm2A:
21.25