SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gm3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		3 / 3 TRP A 146
TYR A 180
LEU A 119
 None
 1.11A 1kxhA-5gm3A:
undetectable		 1kxhA-5gm3A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 ALA A  85
LEU A 123
GLN A 198
LEU A 102
VAL A 174
 None
 1.28A 1u72A-5gm3A:
undetectable		 1u72A-5gm3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 GLY A  93
PHE A 204
GLY A 206
GLY A 207
ALA A 209
 None
 1.14A 2dpmA-5gm3A:
undetectable		 2dpmA-5gm3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 ALA A 209
PRO A 203
GLY A 207
TRP A  53
TYR A  63
 None
 1.27A 2igtC-5gm3A:
undetectable		 2igtC-5gm3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 THR A  49
VAL A  98
ALA A  99
VAL A  60
VAL A 129
 None
 1.20A 2nniA-5gm3A:
undetectable		 2nniA-5gm3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 ALA A  99
LEU A 119
THR A  83
ILE A  81
LEU A 194
 None
 0.92A 2oipE-5gm3A:
undetectable		 2oipE-5gm3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		3 / 3 ASP A 107
TYR A 193
LYS A  72
 None
 0.88A 2othA-5gm3A:
undetectable		 2othA-5gm3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 ALA A  99
LEU A 119
THR A  83
ILE A  81
LEU A 194
 None
 1.16A 3hj3A-5gm3A:
undetectable		 3hj3A-5gm3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 ALA A  99
LEU A 119
THR A  83
ILE A  81
LEU A 194
 None
 1.10A 3hj3B-5gm3A:
undetectable		 3hj3B-5gm3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 ALA A  99
LEU A 119
THR A  83
ILE A  81
LEU A 194
 None
 0.92A 3hj3D-5gm3A:
undetectable		 3hj3D-5gm3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_2
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		4 / 6 THR A  49
ASN A  22
TYR A 100
TRP A  47
 None
 1.28A 3jzjA-5gm3A:
undetectable		 3jzjA-5gm3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		4 / 5 GLU A 118
GLY A 115
TYR A 117
GLN A 192
 None
 1.47A 3w9tB-5gm3A:
undetectable		 3w9tB-5gm3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		4 / 5 GLU A 118
GLY A 115
TYR A 117
GLN A 192
 None
 1.44A 3w9tD-5gm3A:
undetectable		 3w9tD-5gm3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		4 / 7 THR A  35
THR A 210
ALA A 209
THR A 201
 None
 0.94A 4qw0K-5gm3A:
undetectable		 4qw0K-5gm3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		4 / 7 THR A  35
THR A 210
ALA A 209
THR A 201
 None
 0.94A 4qw0Y-5gm3A:
undetectable		 4qw0Y-5gm3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		3 / 3 ASN A  38
SER A  48
SER A 212
 None
 0.78A 5gsnA-5gm3A:
undetectable		 5gsnA-5gm3A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		4 / 6 GLU A 118
PHE A 177
TYR A  63
PHE A 103
 None
 1.37A 5lrbA-5gm3A:
2.2		 5lrbA-5gm3A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 LYS A  73
VAL A 220
ILE A  81
ASP A 176
ASP A 173
 None
 1.48A 6bxnA-5gm3A:
undetectable		 6bxnA-5gm3A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gm3 ENDOGLUCANASE-1
(Aspergillus
aculeatus) 		5 / 12 GLN A 183
HIS A 185
TYR A 159
LEU A 119
ILE A  81
 None
ZN  A 301 (-3.1A)
None
None
None
 1.50A 6md4A-5gm3A:
undetectable		 6md4A-5gm3A:
19.05