SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		4 / 6 LEU Z  94
MET Z  99
LEU Z 121
HIS Z 225
 None
 1.15A 1errB-5gmkZ:
undetectable		 1errB-5gmkZ:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		4 / 5 LEU Z  94
MET Z  99
LEU Z 121
HIS Z 225
 None
 1.13A 2jfaA-5gmkZ:
undetectable		 2jfaA-5gmkZ:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		4 / 5 LEU Z  94
MET Z  99
LEU Z 121
HIS Z 225
 None
 1.15A 2qxsA-5gmkZ:
undetectable		 2qxsA-5gmkZ:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		4 / 5 LEU Z  94
MET Z  99
LEU Z 121
HIS Z 225
 None
 1.13A 2qxsB-5gmkZ:
undetectable		 2qxsB-5gmkZ:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		4 / 6 LEU Z  83
LEU Z  82
ASP Z  86
ILE Z  49
 None
 1.05A 2rlfA-5gmkZ:
undetectable
2rlfB-5gmkZ:
undetectable		 2rlfA-5gmkZ:
6.96
2rlfB-5gmkZ:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		5 / 12 ILE Z 200
ILE Z 135
LEU Z 139
LEU Z 142
ILE Z 152
 None
 1.21A 3adsB-5gmkZ:
undetectable		 3adsB-5gmkZ:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		5 / 10 ALA Z  95
ILE Z  80
ILE Z  73
PRO Z  74
ILE Z 117
 None
 1.22A 3clbD-5gmkZ:
undetectable		 3clbD-5gmkZ:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		5 / 10 ALA Z  95
ILE Z  80
ILE Z  73
PRO Z  74
ILE Z 117
 None
 1.22A 3hbbD-5gmkZ:
undetectable		 3hbbD-5gmkZ:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		5 / 12 LEU Z  37
VAL Z  60
ALA Z  81
ASN Z  84
LEU Z  83
 None
 1.13A 3r9cA-5gmkZ:
undetectable		 3r9cA-5gmkZ:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		4 / 8 GLN Z  38
ALA Z  81
SER Z  85
HIS Z  41
 None
 0.97A 5km8A-5gmkZ:
undetectable
5km8B-5gmkZ:
undetectable		 5km8A-5gmkZ:
12.21
5km8B-5gmkZ:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5gmk PRE-MRNA-SPLICING
FACTOR CWC22
(Saccharomyces
cerevisiae) 		5 / 12 VAL Z  61
ILE Z  21
LEU Z  44
VAL Z  47
ILE Z  49
 None
 1.07A 5mugA-5gmkZ:
undetectable		 5mugA-5gmkZ:
17.31