SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		5 / 9 GLU A 154
HIS A 156
LEU A 161
ALA A 139
LEU A 163
 None
 1.26A 1hwiA-5gmlA:
undetectable		 1hwiA-5gmlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		5 / 11 GLU A 154
HIS A 156
LEU A 161
ALA A 139
LEU A 163
 None
 1.28A 1hwkB-5gmlA:
undetectable		 1hwkB-5gmlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		5 / 11 GLU A 154
HIS A 156
LEU A 161
ALA A 139
LEU A 163
 None
 1.24A 1hwkA-5gmlA:
undetectable		 1hwkA-5gmlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		5 / 11 GLU A 154
HIS A 156
LEU A 161
ALA A 139
LEU A 163
 None
 1.25A 1hwkD-5gmlA:
undetectable		 1hwkD-5gmlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		5 / 11 GLU A 154
HIS A 156
LEU A 161
ALA A 139
LEU A 163
 None
 1.27A 1hwkC-5gmlA:
undetectable		 1hwkC-5gmlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		4 / 7 ARG A  80
ALA A  82
ILE A  40
ILE A  43
 None
 0.99A 1oniD-5gmlA:
undetectable
1oniF-5gmlA:
undetectable		 1oniD-5gmlA:
20.85
1oniF-5gmlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		5 / 11 LEU A  96
GLY A  97
SER A  99
ILE A 100
LEU A  55
 None
 0.82A 2kawA-5gmlA:
3.5		 2kawA-5gmlA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		4 / 8 GLY A  28
GLY A  32
VAL A  84
VAL A  19
 None
 0.89A 4c5nC-5gmlA:
undetectable		 4c5nC-5gmlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2
(Mus
musculus) 		4 / 8 VAL A 112
GLY A 107
SER A  74
GLY A   0
 None
 0.67A 5e26C-5gmlA:
undetectable
5e26D-5gmlA:
undetectable		 5e26C-5gmlA:
19.52
5e26D-5gmlA:
19.52