SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gmo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
3 / 3 LEU A  21
ARG A 239
ILE A  18
None
0.64A 2xn5B-5gmoA:
undetectable
2xn5B-5gmoA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
4 / 5 LEU A 271
GLY A 268
PHE A 266
PHE A 196
None
0.87A 3smtA-5gmoA:
undetectable
3smtA-5gmoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
5 / 12 LEU A  14
SER A 188
HIS A  79
LEU A  78
ILE A  18
None
0.97A 4x1fA-5gmoA:
undetectable
4x1fA-5gmoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
5 / 12 LEU A  14
SER A 188
HIS A  79
LEU A  78
ILE A  18
None
1.02A 4x1gA-5gmoA:
undetectable
4x1gA-5gmoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
5 / 12 GLY A  12
THR A 123
PHE A  50
VAL A  29
ILE A  19
None
1.29A 5tuiB-5gmoA:
3.0
5tuiB-5gmoA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
4 / 4 PHE A 249
LEU A  14
LEU A  21
VAL A 190
None
1.23A 5xxiA-5gmoA:
undetectable
5xxiA-5gmoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
5 / 12 THR A 270
VAL A 219
ASP A 317
PHE A 318
VAL A 323
None
1.30A 6iblA-5gmoA:
undetectable
6iblA-5gmoA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis)
5 / 12 THR A 270
VAL A 219
ASP A 317
PHE A 318
VAL A 323
None
1.35A 6iblB-5gmoA:
undetectable
6iblB-5gmoA:
19.91