SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 ASP A  28
GLY A  76
GLY A  77
GLY A  78
HIS A 269
 None
 1.02A 1dx6A-5gmsA:
16.4		 1dx6A-5gmsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 GLY A 104
PHE A  71
GLY A 147
GLY A 148
ASP A 144
 None
 0.94A 1mxgA-5gmsA:
undetectable		 1mxgA-5gmsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5gms ESTERASE
(uncultured
bacterium) 		3 / 3 ILE A 176
ASP A 243
PHE A 185
 None
 0.66A 1uwjB-5gmsA:
undetectable		 1uwjB-5gmsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 ASP A  28
GLY A  77
GLY A  78
SER A 145
HIS A 269
 None
 1.29A 1w76A-5gmsA:
15.6		 1w76A-5gmsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 ILE A  14
HIS A 269
GLY A  77
TYR A  32
PHE A 274
 None
 1.09A 1zz1B-5gmsA:
undetectable
1zz1C-5gmsA:
undetectable		 1zz1B-5gmsA:
23.66
1zz1C-5gmsA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 GLY A  77
GLY A  78
SER A 145
ALA A 146
HIS A 269
 None
 0.78A 2aceA-5gmsA:
4.3		 2aceA-5gmsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 8 GLY A  77
GLY A  78
ALA A 146
HIS A 269
 None
 0.25A 2ha4A-5gmsA:
5.9		 2ha4A-5gmsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  77
GLY A  78
ALA A 146
HIS A 269
 None
 0.26A 2ha4B-5gmsA:
5.3		 2ha4B-5gmsA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  82
ASP A  28
TYR A  32
ARG A  22
 None
 1.10A 3arrA-5gmsA:
undetectable		 3arrA-5gmsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  82
ASP A  28
TYR A  32
ARG A  22
 None
 1.11A 3aruA-5gmsA:
undetectable		 3aruA-5gmsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 7 PHE A 203
GLY A  77
ASP A  28
TYR A  32
 None
 1.27A 3aruA-5gmsA:
undetectable		 3aruA-5gmsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 LEU A 150
GLY A 149
ILE A 176
PRO A 220
PRO A 216
 None
 1.33A 3bjwE-5gmsA:
undetectable		 3bjwE-5gmsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A 150
GLY A 149
ILE A 176
PRO A 220
PRO A 216
 None
 1.25A 3bjwF-5gmsA:
undetectable		 3bjwF-5gmsA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 5 HIS A  75
ASP A 106
TYR A 107
PRO A 118
 None
 1.37A 3fo7A-5gmsA:
undetectable		 3fo7A-5gmsA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 5 HIS A  75
ASP A 106
TYR A 107
PRO A 118
 None
 1.37A 3h1xA-5gmsA:
undetectable		 3h1xA-5gmsA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 GLY A 142
GLY A 143
VAL A 170
CYH A 100
ILE A 288
 None
 1.13A 3h52B-5gmsA:
undetectable		 3h52B-5gmsA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A  36
GLY A  77
GLY A  76
LEU A 150
ASP A 106
 None
 0.94A 3i5uA-5gmsA:
3.4		 3i5uA-5gmsA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A  36
GLY A  77
GLY A  76
LEU A 150
ASP A 106
 None
 0.93A 3i5uB-5gmsA:
undetectable		 3i5uB-5gmsA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 GLY A 142
LEU A 103
LEU A  91
LEU A 105
LEU A  74
 None
 1.31A 3ndvA-5gmsA:
undetectable
3ndvB-5gmsA:
undetectable		 3ndvA-5gmsA:
25.00
3ndvB-5gmsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 LEU A 105
LEU A  74
GLY A 142
LEU A 103
LEU A  91
 None
 1.30A 3ndvA-5gmsA:
undetectable
3ndvB-5gmsA:
undetectable		 3ndvA-5gmsA:
25.00
3ndvB-5gmsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 GLY A 142
LEU A 103
LEU A  91
LEU A 105
LEU A  74
 None
 1.30A 3ndvC-5gmsA:
undetectable
3ndvD-5gmsA:
undetectable		 3ndvC-5gmsA:
25.00
3ndvD-5gmsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 LEU A 105
LEU A  74
GLY A 142
LEU A 103
LEU A  91
 None
 1.32A 3ndvC-5gmsA:
undetectable
3ndvD-5gmsA:
undetectable		 3ndvC-5gmsA:
25.00
3ndvD-5gmsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 6 GLY A  77
GLY A  78
SER A 145
HIS A 269
 None
 0.66A 3o9mB-5gmsA:
16.8		 3o9mB-5gmsA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 7 ASP A 192
PRO A 268
GLU A 239
ARG A  17
 None
 1.28A 3s3oA-5gmsA:
undetectable		 3s3oA-5gmsA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 5 ARG A 159
LEU A 228
VAL A 257
ASP A 224
 None
 1.14A 3ufnA-5gmsA:
undetectable
3ufnB-5gmsA:
undetectable		 3ufnA-5gmsA:
15.81
3ufnB-5gmsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 11 LEU A 155
ALA A 153
LEU A 248
GLY A 143
LEU A  74
 None
 1.26A 3uudA-5gmsA:
undetectable		 3uudA-5gmsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 7 TYR A  32
SER A 145
TYR A  73
HIS A 273
 None
 1.36A 4arcA-5gmsA:
undetectable		 4arcA-5gmsA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 GLY A 148
ALA A 146
THR A  86
HIS A  87
GLY A  77
 None
 0.81A 4ls7A-5gmsA:
undetectable		 4ls7A-5gmsA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.07A 4qvmK-5gmsA:
undetectable
4qvmL-5gmsA:
undetectable		 4qvmK-5gmsA:
21.74
4qvmL-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.05A 4qvnK-5gmsA:
undetectable
4qvnL-5gmsA:
undetectable		 4qvnK-5gmsA:
21.74
4qvnL-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.05A 4qvnY-5gmsA:
undetectable
4qvnZ-5gmsA:
undetectable		 4qvnY-5gmsA:
21.74
4qvnZ-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 10 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.06A 4qvpK-5gmsA:
undetectable
4qvpL-5gmsA:
undetectable		 4qvpK-5gmsA:
22.15
4qvpL-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 10 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.05A 4qvpY-5gmsA:
undetectable
4qvpZ-5gmsA:
undetectable		 4qvpY-5gmsA:
22.15
4qvpZ-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.04A 4qvqK-5gmsA:
undetectable
4qvqL-5gmsA:
undetectable		 4qvqK-5gmsA:
22.19
4qvqL-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.03A 4qvqY-5gmsA:
undetectable
4qvqZ-5gmsA:
undetectable		 4qvqY-5gmsA:
22.19
4qvqZ-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 10 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.06A 4qw1Y-5gmsA:
undetectable
4qw1Z-5gmsA:
undetectable		 4qw1Y-5gmsA:
21.74
4qw1Z-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 10 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.06A 4qw3K-5gmsA:
undetectable
4qw3L-5gmsA:
undetectable		 4qw3K-5gmsA:
21.74
4qw3L-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 10 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.06A 4qw3Y-5gmsA:
undetectable
4qw3Z-5gmsA:
undetectable		 4qw3Y-5gmsA:
21.74
4qw3Z-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 10 ASP A 106
ALA A 146
ASP A 144
SER A  83
GLY A  77
 None
 1.41A 4xp1A-5gmsA:
undetectable		 4xp1A-5gmsA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 GLY A  76
ASP A 144
ILE A  94
LEU A 105
LEU A  91
 None
 1.04A 5bw4A-5gmsA:
undetectable		 5bw4A-5gmsA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5gms ESTERASE
(uncultured
bacterium) 		3 / 3 GLU A 239
HIS A 269
ASP A 244
 None
 0.85A 5c0oG-5gmsA:
3.4		 5c0oG-5gmsA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.05A 5d0xK-5gmsA:
undetectable
5d0xL-5gmsA:
undetectable		 5d0xK-5gmsA:
19.54
5d0xL-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 1.06A 5d0xY-5gmsA:
undetectable
5d0xZ-5gmsA:
undetectable		 5d0xY-5gmsA:
19.54
5d0xZ-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 GLN A  46
ILE A  45
SER A  92
VAL A  52
LEU A  50
 None
 1.06A 5ergB-5gmsA:
2.7		 5ergB-5gmsA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 5 ALA A 153
PRO A 174
GLY A 281
LEU A 232
 None
 0.89A 5eslA-5gmsA:
undetectable		 5eslA-5gmsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5gms ESTERASE
(uncultured
bacterium) 		4 / 4 LEU A 232
LEU A 292
GLY A 289
GLU A 290
 None
 0.79A 5hhjA-5gmsA:
undetectable		 5hhjA-5gmsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 0.98A 5l5zK-5gmsA:
undetectable
5l5zL-5gmsA:
undetectable		 5l5zK-5gmsA:
22.39
5l5zL-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 9 ALA A 125
THR A 122
ALA A 124
GLY A 104
ALA A  57
 None
 0.98A 5l5zY-5gmsA:
undetectable
5l5zZ-5gmsA:
undetectable		 5l5zY-5gmsA:
22.39
5l5zZ-5gmsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 GLU A 262
GLN A  69
ARG A 287
GLY A 289
LEU A 292
 None
 1.32A 5m50B-5gmsA:
undetectable		 5m50B-5gmsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 GLU A 262
GLN A  69
ARG A 287
GLY A 289
LEU A 292
 None
 1.36A 5m50E-5gmsA:
undetectable		 5m50E-5gmsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A 103
LEU A  72
ALA A 140
LEU A 158
LEU A 130
 None
 1.21A 5mwyA-5gmsA:
undetectable		 5mwyA-5gmsA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 TYR A  32
VAL A 200
ASP A 243
PHE A 185
THR A 181
 None
 1.41A 5vlmD-5gmsA:
undetectable		 5vlmD-5gmsA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 5gms ESTERASE
(uncultured
bacterium) 		5 / 12 GLY A  77
TYR A  73
HIS A 269
PRO A 229
VAL A 195
 None
 1.42A 6gngA-5gmsA:
6.4		 6gngA-5gmsA:
22.70