SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gmt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 7 ILE A 200
PHE A 174
PHE A  89
PHE A 253
 None
 1.24A 1e72M-5gmtA:
undetectable		 1e72M-5gmtA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 11 SER A 149
ILE A 158
VAL A 157
ILE A 143
GLN A 165
 None
 1.20A 1uduA-5gmtA:
undetectable		 1uduA-5gmtA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 7 GLY A  97
SER A 239
SER A 242
ARG A 132
 None
 0.88A 2c8aB-5gmtA:
undetectable		 2c8aB-5gmtA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 7 GLY A  97
SER A 239
SER A 242
ARG A 132
 None
 0.89A 2c8aD-5gmtA:
undetectable		 2c8aD-5gmtA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 11 PHE A 172
GLN A 209
VAL A 202
ILE A 182
TYR A  85
 None
 1.44A 2vcdA-5gmtA:
undetectable		 2vcdA-5gmtA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 12 ILE A 200
PHE A 174
ALA A  46
ILE A 182
MET A 230
 None
 1.08A 2xkwB-5gmtA:
undetectable		 2xkwB-5gmtA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 12 PHE A  92
GLY A  97
GLY A  95
ALA A 245
ASP A 136
 None
 0.88A 2zulA-5gmtA:
undetectable		 2zulA-5gmtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 12 PHE A  92
GLY A  97
GLY A  95
ALA A 245
ASP A 136
 None
 0.92A 3dmfA-5gmtA:
undetectable		 3dmfA-5gmtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 12 PHE A  92
GLY A  97
GLY A  95
ALA A 245
ASP A 136
 None
 0.92A 3dmhA-5gmtA:
undetectable		 3dmhA-5gmtA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 12 PHE A 236
GLY A  64
PHE A 232
SER A 233
ILE A  35
 None
 1.18A 3iv6C-5gmtA:
undetectable		 3iv6C-5gmtA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 9 ILE A  49
ALA A  65
PHE A 232
LEU A  20
ASP A  32
 None
 1.22A 3ti1A-5gmtA:
undetectable		 3ti1A-5gmtA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1001_0
(FORMIN-LIKE PROTEIN
3)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 4 VAL A 191
ASN A 221
ASN A 189
ARG A 220
 None
 1.29A 4eahA-5gmtA:
undetectable
4eahE-5gmtA:
undetectable		 4eahA-5gmtA:
19.90
4eahE-5gmtA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1003_0
(FORMIN-LIKE PROTEIN
3)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 5 ASN A 189
ARG A 220
VAL A 191
ASN A 221
 None
 1.30A 4eahA-5gmtA:
undetectable
4eahE-5gmtA:
undetectable		 4eahA-5gmtA:
19.90
4eahE-5gmtA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_B_ACTB1001_0
(FORMIN-LIKE PROTEIN
3)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 4 VAL A 191
ASN A 221
ASN A 189
ARG A 220
 None
 1.36A 4eahB-5gmtA:
undetectable
4eahC-5gmtA:
undetectable		 4eahB-5gmtA:
19.90
4eahC-5gmtA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		3 / 3 TYR A 140
PHE A 235
ARG A 128
 None
 1.24A 4g19D-5gmtA:
undetectable		 4g19D-5gmtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		3 / 3 TYR A 142
PHE A 235
ARG A 128
 None
 1.16A 4g19D-5gmtA:
undetectable		 4g19D-5gmtA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 12 PHE A  23
GLY A  66
ILE A  26
SER A  69
MET A 230
 None
 1.00A 4qdjA-5gmtA:
undetectable		 4qdjA-5gmtA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		5 / 12 ILE A 200
PHE A 174
PHE A 253
GLY A 137
PHE A 232
 None
 1.13A 5fsaA-5gmtA:
undetectable		 5fsaA-5gmtA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 6 TYR A 140
ASP A 156
LEU A 167
GLY A 168
 None
 1.02A 5nooC-5gmtA:
undetectable		 5nooC-5gmtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5gmt ALGINATE LYASE
(Aplysia
kurodai) 		4 / 6 ARG A 132
GLY A 170
GLU A 138
SER A 166
 None
 1.14A 5ny7A-5gmtA:
undetectable		 5ny7A-5gmtA:
23.42