SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 9 PHE A 350
ILE A 380
LEU A 331
GLY A 372
PHE A 348
 None
 1.50A 1i00A-5gmxA:
undetectable		 1i00A-5gmxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 7 LEU A  48
SER A  35
PHE A  36
ALA A 362
 None
 0.59A 1j8uA-5gmxA:
undetectable		 1j8uA-5gmxA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 11 GLU A 171
ARG A 174
ARG A 175
GLU A 102
ALA A 146
 None
 0.88A 1mjlA-5gmxA:
undetectable
1mjlB-5gmxA:
undetectable		 1mjlA-5gmxA:
13.40
1mjlB-5gmxA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 9 GLU A 171
ARG A 174
ARG A 175
GLU A 102
ALA A 146
 None
 1.02A 1mjoA-5gmxA:
undetectable		 1mjoA-5gmxA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 9 GLU A 171
ARG A 174
ARG A 175
GLU A 102
ALA A 146
 None
 1.02A 1mjoB-5gmxA:
undetectable		 1mjoB-5gmxA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 9 GLU A 171
ARG A 174
ARG A 175
GLU A 102
ALA A 146
 None
 1.02A 1mjoC-5gmxA:
undetectable		 1mjoC-5gmxA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 8 ILE A 294
LEU A 282
PHE A 324
GLY A  75
 None
 0.96A 1os6A-5gmxA:
undetectable		 1os6A-5gmxA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		3 / 3 ASP A  98
ARG A  95
ASP A  91
 None
 0.93A 1vptA-5gmxA:
undetectable		 1vptA-5gmxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 GLY A  37
ILE A   7
GLY A   9
ILE A  10
VAL A  18
 None
 0.91A 2b7zA-5gmxA:
undetectable		 2b7zA-5gmxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 6 TYR A 201
GLY A 272
TYR A 279
ASN A 271
 None
 1.25A 2g72A-5gmxA:
undetectable		 2g72A-5gmxA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 THR A 353
ALA A 283
LEU A 282
LEU A  38
ILE A 380
 None
 1.05A 2jfaA-5gmxA:
undetectable		 2jfaA-5gmxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 GLY A  37
ILE A   7
GLY A   9
ILE A  10
VAL A  18
 None
 0.97A 2nnkB-5gmxA:
undetectable		 2nnkB-5gmxA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 GLY A 286
GLY A 285
PHE A 324
PHE A 339
 None
 0.97A 2qr2A-5gmxA:
undetectable
2qr2B-5gmxA:
undetectable		 2qr2A-5gmxA:
21.80
2qr2B-5gmxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 8 TYR A  92
ALA A 169
ALA A 173
THR A 177
 None
 0.95A 2wx2B-5gmxA:
undetectable		 2wx2B-5gmxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 GLY A 372
GLY A 346
ASP A 367
LEU A 331
ASN A 327
 None
 1.25A 2zw9A-5gmxA:
undetectable		 2zw9A-5gmxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 ILE A 380
GLY A 372
ASP A 367
LEU A 331
ASN A 327
 None
 1.01A 2zw9A-5gmxA:
undetectable		 2zw9A-5gmxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 GLY A 372
GLY A 346
ASP A 367
LEU A 331
ASN A 327
 None
 1.20A 2zw9B-5gmxA:
undetectable		 2zw9B-5gmxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 7 ILE A   7
LEU A  48
PHE A  22
THR A  65
 None
 1.15A 2zxwN-5gmxA:
undetectable
2zxwW-5gmxA:
undetectable		 2zxwN-5gmxA:
22.64
2zxwW-5gmxA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		6 / 10 GLY A 280
ALA A  39
VAL A  46
GLY A 360
ILE A 275
ILE A  44
 None
 1.21A 3ekvA-5gmxA:
undetectable		 3ekvA-5gmxA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 GLY A  37
ILE A   7
GLY A   9
ILE A  10
VAL A  18
 None
 0.93A 3el4A-5gmxA:
undetectable		 3el4A-5gmxA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 8 ARG A 273
ALA A 197
ASN A 199
ARG A 212
 None
 0.99A 3fxrA-5gmxA:
undetectable		 3fxrA-5gmxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 9 GLY A 358
ALA A 351
ASP A 352
GLY A 285
THR A  79
 None
 1.08A 3gguB-5gmxA:
undetectable		 3gguB-5gmxA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 LEU A 379
GLY A 376
PHE A 348
LEU A 357
ASP A 352
 None
 0.89A 3gwvA-5gmxA:
undetectable		 3gwvA-5gmxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 GLY A 298
PHE A 324
GLY A  75
ALA A  77
GLY A  82
 None
 0.98A 3hs6B-5gmxA:
undetectable		 3hs6B-5gmxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 8 TYR A  92
ALA A 169
ALA A 173
THR A 177
 None
 0.95A 3khmA-5gmxA:
undetectable		 3khmA-5gmxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 8 MET A  76
PHE A 187
ALA A 192
ALA A 197
 None
 1.00A 3l4dD-5gmxA:
undetectable		 3l4dD-5gmxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 8 TYR A  92
ALA A 169
ALA A 173
THR A 177
 None
 0.98A 3l4dD-5gmxA:
undetectable		 3l4dD-5gmxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 TYR A 361
GLY A  37
ASP A  47
LEU A  48
ALA A  24
 None
 1.09A 3ou6A-5gmxA:
undetectable		 3ou6A-5gmxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 TYR A 361
GLY A  37
ASP A  47
LEU A  48
ALA A  24
 None
 1.10A 3ou6C-5gmxA:
undetectable		 3ou6C-5gmxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 6 ILE A 294
LEU A 282
PHE A 324
GLY A  75
 None
 1.01A 3sj1X-5gmxA:
undetectable		 3sj1X-5gmxA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 7 ALA A 238
ARG A 127
HIS A 161
GLY A 122
 None
 1.01A 3v4tH-5gmxA:
undetectable		 3v4tH-5gmxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		3 / 3 ARG A 304
TYR A 279
ASN A 335
 None
 0.93A 4ffwB-5gmxA:
undetectable		 4ffwB-5gmxA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 11 ILE A 168
GLN A 120
LEU A 116
THR A 112
VAL A  96
 None
 1.13A 4g1bB-5gmxA:
undetectable		 4g1bB-5gmxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 7 ILE A 294
LEU A 282
PHE A 324
GLY A  75
 None
 1.01A 4hbfA-5gmxA:
undetectable		 4hbfA-5gmxA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 7 ILE A 294
LEU A 282
PHE A 324
GLY A  75
 None
 0.94A 4hc3A-5gmxA:
undetectable		 4hc3A-5gmxA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 ALA A 338
GLY A 333
ALA A 276
GLY A 349
PHE A 350
 None
 1.20A 4r29C-5gmxA:
undetectable		 4r29C-5gmxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		4 / 5 GLU A 171
SER A 182
GLN A 185
ASP A 137
 None
 1.49A 5fhrB-5gmxA:
undetectable		 5fhrB-5gmxA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5gmx CARBOXYLESTERASE
(uncultured
bacterium) 		5 / 12 PHE A  22
ALA A 214
GLY A  33
GLY A  51
ILE A   7
 None
 1.21A 5ul4A-5gmxA:
undetectable		 5ul4A-5gmxA:
19.23