SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		5 / 12 HIS A1060
ILE A1070
LEU A1073
LEU A 970
VAL A 969
 None
 1.09A 1axwA-5gn1A:
undetectable		 1axwA-5gn1A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		5 / 12 HIS A1060
ILE A1070
LEU A1073
LEU A 970
VAL A 969
 None
 1.11A 1tlsB-5gn1A:
undetectable		 1tlsB-5gn1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 939
TYR A 885
TRP A 945
GLU A 944
 None
 1.47A 2aowA-5gn1A:
undetectable		 2aowA-5gn1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 868
LEU A1115
TYR A 830
THR A1075
 None
 1.06A 3ablA-5gn1A:
2.5
3ablJ-5gn1A:
undetectable		 3ablA-5gn1A:
19.16
3ablJ-5gn1A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 868
LEU A1115
TYR A 830
THR A1075
 None
 1.04A 3ag2N-5gn1A:
2.2
3ag2W-5gn1A:
undetectable		 3ag2N-5gn1A:
19.16
3ag2W-5gn1A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 927
LEU A 924
ILE A 890
ILE A 897
ASP A 915
 None
 0.82A 3gcsA-5gn1A:
undetectable		 3gcsA-5gn1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 927
LEU A 924
ILE A 890
ILE A 897
ASP A 915
 None
 0.80A 3hegA-5gn1A:
2.2		 3hegA-5gn1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 817
ARG A 872
ILE A1074
THR A 815
 None
 1.29A 3ia4C-5gn1A:
undetectable		 3ia4C-5gn1A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		5 / 12 THR A1072
HIS A1084
ILE A1074
LEU A 876
VAL A 978
 None
 1.19A 3sp9A-5gn1A:
undetectable		 3sp9A-5gn1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 868
LEU A1115
TYR A 830
THR A1075
 None
 1.05A 3wg7A-5gn1A:
2.4
3wg7J-5gn1A:
undetectable		 3wg7A-5gn1A:
19.16
3wg7J-5gn1A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1017
LYS A1016
ASP A1015
 None
 0.79A 4a7tA-5gn1A:
undetectable		 4a7tA-5gn1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 989
LEU A 982
THR A1071
ILE A1020
ILE A 961
 None
 1.12A 4o2bB-5gn1A:
undetectable		 4o2bB-5gn1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		3 / 3 MET A 919
GLU A 923
LEU A 927
 None
 0.49A 4v2oB-5gn1A:
undetectable		 4v2oB-5gn1A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gn1 ATP-DEPENDENT
HELICASE FUN30
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 868
LEU A1115
TYR A 830
THR A1075
 None
 1.05A 5b1aN-5gn1A:
2.5
5b1aW-5gn1A:
undetectable		 5b1aN-5gn1A:
19.16
5b1aW-5gn1A:
10.78