SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 TRP A 465
ALA A 473
VAL A 471
 None
 0.97A 1av2C-5gn5A:
undetectable
1av2D-5gn5A:
undetectable		 1av2C-5gn5A:
2.16
1av2D-5gn5A:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.45A 1d1vA-5gn5A:
undetectable
1d1vB-5gn5A:
undetectable		 1d1vA-5gn5A:
22.69
1d1vB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 1d1vA-5gn5A:
undetectable
1d1vB-5gn5A:
undetectable		 1d1vA-5gn5A:
22.69
1d1vB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.47A 1d1wA-5gn5A:
undetectable
1d1wB-5gn5A:
undetectable		 1d1wA-5gn5A:
22.69
1d1wB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_B_H4BB601_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 1d1wA-5gn5A:
undetectable
1d1wB-5gn5A:
undetectable		 1d1wA-5gn5A:
22.69
1d1wB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_A_H4BA600_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 1d1xA-5gn5A:
undetectable
1d1xB-5gn5A:
undetectable		 1d1xA-5gn5A:
22.69
1d1xB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_B_H4BB601_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.46A 1d1xA-5gn5A:
undetectable
1d1xB-5gn5A:
undetectable		 1d1xA-5gn5A:
22.69
1d1xB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.47A 1dm8A-5gn5A:
undetectable
1dm8B-5gn5A:
undetectable		 1dm8A-5gn5A:
22.69
1dm8B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_B_H4BB2600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 1dm8A-5gn5A:
undetectable
1dm8B-5gn5A:
undetectable		 1dm8A-5gn5A:
22.69
1dm8B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_B_BHSB2610_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.46A 1dmiA-5gn5A:
undetectable
1dmiB-5gn5A:
undetectable		 1dmiA-5gn5A:
22.69
1dmiB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 1fopA-5gn5A:
undetectable
1fopB-5gn5A:
undetectable		 1fopA-5gn5A:
22.69
1fopB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 ALA A 461
VAL A 464
TRP A 465
 None
 0.87A 1kqeA-5gn5A:
undetectable
1kqeE-5gn5A:
undetectable		 1kqeA-5gn5A:
1.56
1kqeE-5gn5A:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 ALA A 461
VAL A 464
TRP A 465
 None
 0.88A 1kqeB-5gn5A:
undetectable
1kqeD-5gn5A:
undetectable		 1kqeB-5gn5A:
1.56
1kqeD-5gn5A:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 TRP A 465
ALA A 461
VAL A 464
 None
 0.86A 1kqeB-5gn5A:
undetectable
1kqeD-5gn5A:
undetectable		 1kqeB-5gn5A:
1.56
1kqeD-5gn5A:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 TRP A 465
ALA A 461
VAL A 464
 None
 0.86A 1kqeA-5gn5A:
undetectable
1kqeE-5gn5A:
undetectable		 1kqeA-5gn5A:
1.56
1kqeE-5gn5A:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 1nseA-5gn5A:
undetectable
1nseB-5gn5A:
undetectable		 1nseA-5gn5A:
22.69
1nseB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.44A 1p6lA-5gn5A:
undetectable
1p6lB-5gn5A:
undetectable		 1p6lA-5gn5A:
22.59
1p6lB-5gn5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.43A 1p6mA-5gn5A:
undetectable
1p6mB-5gn5A:
undetectable		 1p6mA-5gn5A:
22.59
1p6mB-5gn5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 1p6mA-5gn5A:
undetectable
1p6mB-5gn5A:
undetectable		 1p6mA-5gn5A:
22.59
1p6mB-5gn5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 1p6nA-5gn5A:
undetectable
1p6nB-5gn5A:
undetectable		 1p6nA-5gn5A:
22.59
1p6nB-5gn5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 1q2oA-5gn5A:
undetectable
1q2oB-5gn5A:
undetectable		 1q2oA-5gn5A:
22.63
1q2oB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 1rs8A-5gn5A:
undetectable
1rs8B-5gn5A:
undetectable		 1rs8A-5gn5A:
22.63
1rs8B-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 1rs8A-5gn5A:
undetectable
1rs8B-5gn5A:
undetectable		 1rs8A-5gn5A:
22.63
1rs8B-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 1rs9A-5gn5A:
undetectable
1rs9B-5gn5A:
undetectable		 1rs9A-5gn5A:
22.63
1rs9B-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 1zzsA-5gn5A:
undetectable
1zzsB-5gn5A:
undetectable		 1zzsA-5gn5A:
22.63
1zzsB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 5 LEU A 429
ILE A 432
LEU A 436
SER A 435
ARG A 493
 None
 1.48A 2byoA-5gn5A:
undetectable		 2byoA-5gn5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
GLY A 321
ALA A 320
GLY A 421
ILE A 395
 None
 1.00A 2f80A-5gn5A:
undetectable		 2f80A-5gn5A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 ALA A 473
VAL A 471
TRP A 465
 None
 0.94A 2izqA-5gn5A:
undetectable
2izqB-5gn5A:
undetectable		 2izqA-5gn5A:
2.16
2izqB-5gn5A:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 8 MET A 263
LEU A 456
PRO A 444
MET A 446
 None
 1.13A 2qd2A-5gn5A:
undetectable		 2qd2A-5gn5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 11 THR A 246
ILE A  78
ILE A  62
ALA A 241
VAL A 231
 None
 1.20A 2qhfA-5gn5A:
undetectable		 2qhfA-5gn5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 GLN A 302
THR A 185
TRP A 203
 None
 1.17A 2rctA-5gn5A:
undetectable		 2rctA-5gn5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 8 ALA A 454
ALA A 451
GLY A  10
SER A 257
 None
 0.92A 2vh3B-5gn5A:
undetectable		 2vh3B-5gn5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 8 CYH A 457
PHE A 260
THR A  81
ILE A 252
 None
 0.96A 3bpxA-5gn5A:
1.5
3bpxB-5gn5A:
undetectable		 3bpxA-5gn5A:
15.69
3bpxB-5gn5A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.45A 3dqsA-5gn5A:
undetectable
3dqsB-5gn5A:
undetectable		 3dqsA-5gn5A:
22.63
3dqsB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 3dqsA-5gn5A:
undetectable
3dqsB-5gn5A:
undetectable		 3dqsA-5gn5A:
22.63
3dqsB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.41A 3dqtA-5gn5A:
undetectable
3dqtB-5gn5A:
undetectable		 3dqtA-5gn5A:
22.63
3dqtB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.45A 3dqtA-5gn5A:
undetectable
3dqtB-5gn5A:
undetectable		 3dqtA-5gn5A:
22.63
3dqtB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 ILE A 252
ALA A 258
LEU A 281
GLN A  83
THR A 450
 None
 1.17A 3ix9B-5gn5A:
undetectable		 3ix9B-5gn5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 3jwxA-5gn5A:
0.4
3jwxB-5gn5A:
undetectable		 3jwxA-5gn5A:
22.69
3jwxB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 3jwyA-5gn5A:
undetectable
3jwyB-5gn5A:
undetectable		 3jwyA-5gn5A:
22.69
3jwyB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 3jwyA-5gn5A:
undetectable
3jwyB-5gn5A:
undetectable		 3jwyA-5gn5A:
22.69
3jwyB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 3jwzA-5gn5A:
undetectable
3jwzB-5gn5A:
0.2		 3jwzA-5gn5A:
22.69
3jwzB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 TRP A 465
ALA A 473
VAL A 471
 None
 0.94A 3l8lA-5gn5A:
undetectable
3l8lB-5gn5A:
undetectable		 3l8lA-5gn5A:
2.16
3l8lB-5gn5A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 PHE A  72
ILE A  62
ALA A  77
THR A 246
 None
 0.86A 3mdrB-5gn5A:
undetectable		 3mdrB-5gn5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
GLY A 321
ALA A 320
GLY A 421
ILE A 395
 None
 1.03A 3mwsA-5gn5A:
undetectable		 3mwsA-5gn5A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.46A 3n5pA-5gn5A:
undetectable
3n5pB-5gn5A:
undetectable		 3n5pA-5gn5A:
22.69
3n5pB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 3n5rA-5gn5A:
undetectable
3n5rB-5gn5A:
undetectable		 3n5rA-5gn5A:
22.69
3n5rB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.50A 3n5sA-5gn5A:
undetectable
3n5sB-5gn5A:
undetectable		 3n5sA-5gn5A:
22.69
3n5sB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 3n5sA-5gn5A:
undetectable
3n5sB-5gn5A:
undetectable		 3n5sA-5gn5A:
22.69
3n5sB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 3n6eA-5gn5A:
undetectable
3n6eB-5gn5A:
undetectable		 3n6eA-5gn5A:
22.69
3n6eB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 3n6fA-5gn5A:
undetectable
3n6fB-5gn5A:
undetectable		 3n6fA-5gn5A:
22.69
3n6fB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.50A 3nleA-5gn5A:
undetectable
3nleB-5gn5A:
undetectable		 3nleA-5gn5A:
22.69
3nleB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 3nleA-5gn5A:
undetectable
3nleB-5gn5A:
undetectable		 3nleA-5gn5A:
22.69
3nleB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLF_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.45A 3nlfA-5gn5A:
undetectable
3nlfB-5gn5A:
undetectable		 3nlfA-5gn5A:
22.69
3nlfB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 3nlgA-5gn5A:
undetectable
3nlgB-5gn5A:
undetectable		 3nlgA-5gn5A:
22.69
3nlgB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 3nlhA-5gn5A:
undetectable
3nlhB-5gn5A:
undetectable		 3nlhA-5gn5A:
22.69
3nlhB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 3nliA-5gn5A:
undetectable
3nliB-5gn5A:
undetectable		 3nliA-5gn5A:
22.69
3nliB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 3nliA-5gn5A:
1.1
3nliB-5gn5A:
undetectable		 3nliA-5gn5A:
22.69
3nliB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 3nosA-5gn5A:
undetectable
3nosB-5gn5A:
undetectable		 3nosA-5gn5A:
23.15
3nosB-5gn5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
GLY A 321
ALA A 320
GLY A 421
ILE A 395
 None
 0.95A 3nu3A-5gn5A:
undetectable		 3nu3A-5gn5A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 3pnhA-5gn5A:
undetectable
3pnhB-5gn5A:
undetectable		 3pnhA-5gn5A:
22.63
3pnhB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 3pnhA-5gn5A:
undetectable
3pnhB-5gn5A:
undetectable		 3pnhA-5gn5A:
22.63
3pnhB-5gn5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
GLY A 321
ALA A 320
GLY A 421
ILE A 395
 None
 1.03A 3pwmA-5gn5A:
undetectable		 3pwmA-5gn5A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQO_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 3rqoA-5gn5A:
0.0
3rqoB-5gn5A:
undetectable		 3rqoA-5gn5A:
22.69
3rqoB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
LEU A 504
LEU A 399
ILE A 317
ALA A 364
 None
 1.03A 3uwlD-5gn5A:
undetectable		 3uwlD-5gn5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 4c3aA-5gn5A:
undetectable
4c3aB-5gn5A:
undetectable		 4c3aA-5gn5A:
22.69
4c3aB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4cftA-5gn5A:
undetectable
4cftB-5gn5A:
undetectable		 4cftA-5gn5A:
22.69
4cftB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 4cftA-5gn5A:
undetectable
4cftB-5gn5A:
undetectable		 4cftA-5gn5A:
22.69
4cftB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 4ctyA-5gn5A:
undetectable
4ctyB-5gn5A:
undetectable		 4ctyA-5gn5A:
22.69
4ctyB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4ctyA-5gn5A:
undetectable
4ctyB-5gn5A:
undetectable		 4ctyA-5gn5A:
22.69
4ctyB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 4ctzA-5gn5A:
undetectable
4ctzB-5gn5A:
undetectable		 4ctzA-5gn5A:
22.69
4ctzB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4cu0A-5gn5A:
undetectable
4cu0B-5gn5A:
undetectable		 4cu0A-5gn5A:
22.69
4cu0B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4cu1A-5gn5A:
undetectable
4cu1B-5gn5A:
undetectable		 4cu1A-5gn5A:
22.69
4cu1B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 4cwvA-5gn5A:
undetectable
4cwvB-5gn5A:
undetectable		 4cwvA-5gn5A:
22.69
4cwvB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4cwwA-5gn5A:
undetectable
4cwwB-5gn5A:
undetectable		 4cwwA-5gn5A:
22.69
4cwwB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4cwzA-5gn5A:
undetectable
4cwzB-5gn5A:
undetectable		 4cwzA-5gn5A:
22.69
4cwzB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 4cwzA-5gn5A:
undetectable
4cwzB-5gn5A:
undetectable		 4cwzA-5gn5A:
22.69
4cwzB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 4cx0A-5gn5A:
undetectable
4cx0B-5gn5A:
undetectable		 4cx0A-5gn5A:
22.69
4cx0B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4cx0A-5gn5A:
undetectable
4cx0B-5gn5A:
undetectable		 4cx0A-5gn5A:
22.69
4cx0B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4d1oA-5gn5A:
undetectable
4d1oB-5gn5A:
undetectable		 4d1oA-5gn5A:
21.73
4d1oB-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4d1oA-5gn5A:
undetectable
4d1oB-5gn5A:
undetectable		 4d1oA-5gn5A:
21.73
4d1oB-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.46A 4d1pA-5gn5A:
undetectable
4d1pB-5gn5A:
undetectable		 4d1pA-5gn5A:
21.73
4d1pB-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 4d34A-5gn5A:
0.5
4d34B-5gn5A:
undetectable		 4d34A-5gn5A:
22.69
4d34B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 4d36A-5gn5A:
undetectable
4d36B-5gn5A:
undetectable		 4d36A-5gn5A:
22.69
4d36B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4d36A-5gn5A:
undetectable
4d36B-5gn5A:
undetectable		 4d36A-5gn5A:
22.69
4d36B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.46A 4d37A-5gn5A:
undetectable
4d37B-5gn5A:
0.6		 4d37A-5gn5A:
22.69
4d37B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4d38A-5gn5A:
undetectable
4d38B-5gn5A:
0.0		 4d38A-5gn5A:
22.69
4d38B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.44A 4d38A-5gn5A:
undetectable
4d38B-5gn5A:
0.0		 4d38A-5gn5A:
22.69
4d38B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 4d3aA-5gn5A:
undetectable
4d3aB-5gn5A:
undetectable		 4d3aA-5gn5A:
22.69
4d3aB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 PHE A 228
VAL A 184
GLU A 220
 None
 0.83A 4fvqA-5gn5A:
undetectable		 4fvqA-5gn5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 10 ILE A 213
ALA A 141
PHE A 166
PRO A  97
THR A 193
 None
 1.27A 4g8zX-5gn5A:
undetectable		 4g8zX-5gn5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 11 ILE A 213
ALA A 141
PHE A 166
LEU A 164
THR A 193
 None
 1.27A 4i1nA-5gn5A:
undetectable		 4i1nA-5gn5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
GLY A 321
ALA A 320
GLY A 421
ILE A 395
 None
 1.02A 4jecB-5gn5A:
undetectable		 4jecB-5gn5A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4jskA-5gn5A:
undetectable
4jskB-5gn5A:
undetectable		 4jskA-5gn5A:
22.69
4jskB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4jsmA-5gn5A:
undetectable
4jsmB-5gn5A:
undetectable		 4jsmA-5gn5A:
22.69
4jsmB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4k5iA-5gn5A:
undetectable
4k5iB-5gn5A:
undetectable		 4k5iA-5gn5A:
22.69
4k5iB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 4kcpA-5gn5A:
undetectable
4kcpB-5gn5A:
undetectable		 4kcpA-5gn5A:
22.69
4kcpB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 4kcpA-5gn5A:
undetectable
4kcpB-5gn5A:
undetectable		 4kcpA-5gn5A:
22.69
4kcpB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4kcrA-5gn5A:
undetectable
4kcrB-5gn5A:
0.1		 4kcrA-5gn5A:
22.69
4kcrB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.50A 4kcsA-5gn5A:
undetectable
4kcsB-5gn5A:
undetectable		 4kcsA-5gn5A:
22.69
4kcsB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 4kcsA-5gn5A:
undetectable
4kcsB-5gn5A:
undetectable		 4kcsA-5gn5A:
22.69
4kcsB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFL_B_GCSB502_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 GLN A  23
TRP A 465
ALA A 455
PHE A 260
 None
 1.49A 4mflA-5gn5A:
undetectable		 4mflA-5gn5A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 4uh7A-5gn5A:
undetectable
4uh7B-5gn5A:
undetectable		 4uh7A-5gn5A:
22.69
4uh7B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4uh7A-5gn5A:
undetectable
4uh7B-5gn5A:
undetectable		 4uh7A-5gn5A:
22.69
4uh7B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.50A 4uh8A-5gn5A:
undetectable
4uh8B-5gn5A:
undetectable		 4uh8A-5gn5A:
22.69
4uh8B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 4uh8A-5gn5A:
undetectable
4uh8B-5gn5A:
undetectable		 4uh8A-5gn5A:
22.69
4uh8B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.47A 4uh9A-5gn5A:
undetectable
4uh9B-5gn5A:
0.0		 4uh9A-5gn5A:
22.69
4uh9B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.44A 4uh9A-5gn5A:
undetectable
4uh9B-5gn5A:
0.0		 4uh9A-5gn5A:
22.69
4uh9B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 4uhaA-5gn5A:
undetectable
4uhaB-5gn5A:
undetectable		 4uhaA-5gn5A:
22.69
4uhaB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.48A 4uhaA-5gn5A:
undetectable
4uhaB-5gn5A:
undetectable		 4uhaA-5gn5A:
22.69
4uhaB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 4uprA-5gn5A:
undetectable
4uprB-5gn5A:
undetectable		 4uprA-5gn5A:
22.69
4uprB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 4uptA-5gn5A:
undetectable
4uptB-5gn5A:
undetectable		 4uptA-5gn5A:
22.69
4uptB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 11 PHE A 140
GLY A 300
GLU A 314
GLN A 256
ALA A 190
 None
None
6XZ  A 601 (-3.5A)
None
None
 1.18A 4wnuC-5gn5A:
undetectable		 4wnuC-5gn5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 5adjA-5gn5A:
undetectable
5adjB-5gn5A:
undetectable		 5adjA-5gn5A:
22.69
5adjB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 5adkA-5gn5A:
undetectable
5adkB-5gn5A:
undetectable		 5adkA-5gn5A:
22.69
5adkB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 5adkA-5gn5A:
undetectable
5adkB-5gn5A:
undetectable		 5adkA-5gn5A:
22.69
5adkB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 5adlA-5gn5A:
undetectable
5adlB-5gn5A:
undetectable		 5adlA-5gn5A:
22.69
5adlB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.48A 5admA-5gn5A:
undetectable
5admB-5gn5A:
undetectable		 5admA-5gn5A:
22.69
5admB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 5adnA-5gn5A:
undetectable
5adnB-5gn5A:
undetectable		 5adnA-5gn5A:
22.69
5adnB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 5fj2A-5gn5A:
undetectable
5fj2B-5gn5A:
undetectable		 5fj2A-5gn5A:
22.69
5fj2B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.45A 5fvyA-5gn5A:
undetectable
5fvyB-5gn5A:
undetectable		 5fvyA-5gn5A:
22.69
5fvyB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 5fvyA-5gn5A:
undetectable
5fvyB-5gn5A:
undetectable		 5fvyA-5gn5A:
22.69
5fvyB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.45A 5fvzA-5gn5A:
undetectable
5fvzB-5gn5A:
undetectable		 5fvzA-5gn5A:
22.69
5fvzB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 ASP A   8
ALA A 451
ASP A  20
PRO A  25
PHE A  19
 None
 1.40A 5hfjH-5gn5A:
undetectable		 5hfjH-5gn5A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 ASP A 186
GLY A 253
ASP A 254
ASP A 170
 None
None
GOL  A 602 (-2.5A)
None
 1.19A 5hp1A-5gn5A:
4.1		 5hp1A-5gn5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
LEU A 504
LEU A 399
ILE A 317
ALA A 364
 None
 1.01A 5j7wC-5gn5A:
undetectable		 5j7wC-5gn5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		3 / 3 CYH A  99
MET A 148
ASN A 151
 None
 1.37A 5qh8A-5gn5A:
undetectable		 5qh8A-5gn5A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 5uo8A-5gn5A:
0.0
5uo8B-5gn5A:
undetectable		 5uo8A-5gn5A:
21.73
5uo8B-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.46A 5uo8C-5gn5A:
0.6
5uo8D-5gn5A:
undetectable		 5uo8C-5gn5A:
21.73
5uo8D-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 5uo9A-5gn5A:
undetectable
5uo9B-5gn5A:
undetectable		 5uo9A-5gn5A:
21.73
5uo9B-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.40A 5uo9C-5gn5A:
undetectable
5uo9D-5gn5A:
0.0		 5uo9C-5gn5A:
21.73
5uo9D-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 5uodA-5gn5A:
undetectable
5uodB-5gn5A:
undetectable		 5uodA-5gn5A:
22.69
5uodB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.44A 5vv6A-5gn5A:
undetectable
5vv6B-5gn5A:
undetectable		 5vv6A-5gn5A:
22.69
5vv6B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 5vv6A-5gn5A:
undetectable
5vv6B-5gn5A:
undetectable		 5vv6A-5gn5A:
22.69
5vv6B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.47A 5vv7A-5gn5A:
undetectable
5vv7B-5gn5A:
undetectable		 5vv7A-5gn5A:
22.69
5vv7B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.43A 5vv8A-5gn5A:
undetectable
5vv8B-5gn5A:
undetectable		 5vv8A-5gn5A:
22.69
5vv8B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 5vv9A-5gn5A:
undetectable
5vv9B-5gn5A:
undetectable		 5vv9A-5gn5A:
22.69
5vv9B-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.43A 5vvbA-5gn5A:
0.7
5vvbB-5gn5A:
0.0		 5vvbA-5gn5A:
21.73
5vvbB-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.45A 5vvcA-5gn5A:
undetectable
5vvcB-5gn5A:
undetectable		 5vvcA-5gn5A:
21.73
5vvcB-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.50A 5vvcC-5gn5A:
0.7
5vvcD-5gn5A:
undetectable		 5vvcC-5gn5A:
21.73
5vvcD-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.45A 5vvdA-5gn5A:
undetectable
5vvdB-5gn5A:
undetectable		 5vvdA-5gn5A:
21.73
5vvdB-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 5vvdC-5gn5A:
0.7
5vvdD-5gn5A:
undetectable		 5vvdC-5gn5A:
21.73
5vvdD-5gn5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.45A 5vvgA-5gn5A:
undetectable
5vvgB-5gn5A:
undetectable		 5vvgA-5gn5A:
22.69
5vvgB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.43A 5vvnA-5gn5A:
undetectable
5vvnB-5gn5A:
undetectable		 5vvnA-5gn5A:
22.69
5vvnB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.43A 5vvnA-5gn5A:
undetectable
5vvnB-5gn5A:
undetectable		 5vvnA-5gn5A:
22.69
5vvnB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 GLY A 300
TYR A 310
LEU A 198
VAL A 187
 None
 0.94A 5x80A-5gn5A:
undetectable
5x80B-5gn5A:
undetectable		 5x80A-5gn5A:
16.73
5x80B-5gn5A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.43A 6av6A-5gn5A:
undetectable
6av6B-5gn5A:
undetectable		 6av6A-5gn5A:
11.27
6av6B-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 6av6A-5gn5A:
undetectable
6av6B-5gn5A:
undetectable		 6av6A-5gn5A:
11.27
6av6B-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.47A 6av6C-5gn5A:
0.8
6av6D-5gn5A:
0.0		 6av6C-5gn5A:
11.27
6av6D-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.42A 6av6C-5gn5A:
0.8
6av6D-5gn5A:
0.0		 6av6C-5gn5A:
11.27
6av6D-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.47A 6av7A-5gn5A:
undetectable
6av7B-5gn5A:
0.0		 6av7A-5gn5A:
11.27
6av7B-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.47A 6av7C-5gn5A:
0.7
6av7D-5gn5A:
undetectable		 6av7C-5gn5A:
11.27
6av7D-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.45A 6av7C-5gn5A:
0.7
6av7D-5gn5A:
undetectable		 6av7C-5gn5A:
11.27
6av7D-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.43A 6cieA-5gn5A:
undetectable
6cieB-5gn5A:
0.0		 6cieA-5gn5A:
11.27
6cieB-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.49A 6cieA-5gn5A:
undetectable
6cieB-5gn5A:
undetectable		 6cieA-5gn5A:
11.27
6cieB-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.46A 6cieC-5gn5A:
0.7
6cieD-5gn5A:
undetectable		 6cieC-5gn5A:
11.27
6cieD-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.45A 6cieC-5gn5A:
0.7
6cieD-5gn5A:
0.0		 6cieC-5gn5A:
11.27
6cieD-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.44A 6cifA-5gn5A:
0.0
6cifB-5gn5A:
0.0		 6cifA-5gn5A:
11.27
6cifB-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 7 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.44A 6cifC-5gn5A:
undetectable
6cifD-5gn5A:
undetectable		 6cifC-5gn5A:
11.27
6cifD-5gn5A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
GLY A 321
ALA A 320
GLY A 421
ILE A 395
 None
 1.02A 6dh3B-5gn5A:
undetectable		 6dh3B-5gn5A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
GLY A 321
ALA A 320
GLY A 421
ILE A 395
 None
 1.04A 6dh6B-5gn5A:
undetectable		 6dh6B-5gn5A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
LEU A 504
LEU A 399
ILE A 317
ALA A 364
 None
 1.06A 6qxsD-5gn5A:
undetectable		 6qxsD-5gn5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
LEU A 504
LEU A 399
ILE A 317
ALA A 364
 None
 1.06A 6qyaB-5gn5A:
undetectable		 6qyaB-5gn5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		5 / 12 LEU A 392
LEU A 504
LEU A 399
ILE A 317
ALA A 364
 None
 1.03A 6qyaD-5gn5A:
undetectable		 6qyaD-5gn5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.45A 8nseA-5gn5A:
undetectable
8nseB-5gn5A:
undetectable		 8nseA-5gn5A:
22.69
8nseB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 TRP A 326
PHE A 359
GLU A 325
VAL A 324
 None
 1.50A 8nseA-5gn5A:
undetectable
8nseB-5gn5A:
undetectable		 8nseA-5gn5A:
22.69
8nseB-5gn5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5gn5 GLYCEROL KINASE
(Trypanosoma
brucei) 		4 / 6 VAL A 324
TRP A 326
PHE A 359
GLU A 325
 None
 1.49A 9nseA-5gn5A:
undetectable
9nseB-5gn5A:
undetectable		 9nseA-5gn5A:
22.69
9nseB-5gn5A:
22.69