SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gnb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5gnb SPIKE GLYCOPROTEIN
(Human
coronavirus
HKU1) 		4 / 6 THR A 603
ASP A 625
THR A 630
ASP A 623
 None
 1.28A 2okcB-5gnbA:
undetectable		 2okcB-5gnbA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5gnb SPIKE GLYCOPROTEIN
(Human
coronavirus
HKU1) 		4 / 8 GLN A 535
PHE A 574
GLY A 550
GLY A 557
 None
 0.78A 2y6rB-5gnbA:
undetectable		 2y6rB-5gnbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5gnb SPIKE GLYCOPROTEIN
(Human
coronavirus
HKU1) 		3 / 3 TYR A 627
TYR A 651
ILE A 657
 None
 0.84A 3eteA-5gnbA:
undetectable
3eteB-5gnbA:
undetectable		 3eteA-5gnbA:
19.61
3eteB-5gnbA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 5gnb SPIKE GLYCOPROTEIN
(Human
coronavirus
HKU1) 		5 / 11 GLN A 535
PHE A 574
GLY A 550
PRO A 475
GLY A 557
 None
 1.15A 3v3nA-5gnbA:
undetectable		 3v3nA-5gnbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gnb SPIKE GLYCOPROTEIN
(Human
coronavirus
HKU1) 		4 / 7 LEU A 409
TYR A 414
PRO A 341
LEU A 401
 None
 1.05A 4z4fA-5gnbA:
undetectable		 4z4fA-5gnbA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5gnb SPIKE GLYCOPROTEIN
(Human
coronavirus
HKU1) 		3 / 3 SER A 381
SER A 606
PHE A 373
 None
 0.76A 5mugA-5gnbA:
undetectable		 5mugA-5gnbA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5gnb SPIKE GLYCOPROTEIN
(Human
coronavirus
HKU1) 		4 / 7 LEU A 409
TYR A 414
PRO A 341
LEU A 401
 None
 1.01A 5t7bA-5gnbA:
undetectable		 5t7bA-5gnbA:
16.88