SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gnc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5gnc AVH146
(Phytophthora
sojae) 		5 / 10 LEU A 288
ASP A 287
THR A 341
THR A 344
THR A 296
 None
 1.25A 1i18A-5gncA:
undetectable
1i18B-5gncA:
undetectable		 1i18A-5gncA:
11.48
1i18B-5gncA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5gnc AVH146
(Phytophthora
sojae) 		5 / 10 THR A 296
LEU A 288
ASP A 287
THR A 341
THR A 344
 None
 1.26A 1i18A-5gncA:
undetectable
1i18B-5gncA:
undetectable		 1i18A-5gncA:
11.48
1i18B-5gncA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.92A 1v54A-5gncA:
2.0
1v54J-5gncA:
undetectable		 1v54A-5gncA:
21.10
1v54J-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5gnc AVH146
(Phytophthora
sojae) 		3 / 3 LYS A 399
ASP A 325
ASP A 360
 None
 0.99A 2br4D-5gncA:
undetectable		 2br4D-5gncA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.92A 2dyrA-5gncA:
2.0
2dyrJ-5gncA:
undetectable		 2dyrA-5gncA:
21.10
2dyrJ-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 5 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.95A 2eimJ-5gncA:
undetectable		 2eimJ-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.92A 2zxwA-5gncA:
2.2
2zxwJ-5gncA:
undetectable		 2zxwA-5gncA:
21.10
2zxwJ-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 5 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 3ag2J-5gncA:
undetectable		 3ag2J-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 5 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 3ag4J-5gncA:
undetectable		 3ag4J-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 3asnA-5gncA:
2.1
3asnJ-5gncA:
undetectable		 3asnA-5gncA:
21.10
3asnJ-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.93A 3asoA-5gncA:
2.1
3asoJ-5gncA:
undetectable		 3asoA-5gncA:
21.10
3asoJ-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5gnc AVH146
(Phytophthora
sojae) 		5 / 11 LEU A 332
GLU A 351
LEU A 316
VAL A 315
PHE A 294
 None
 1.28A 3jw5A-5gncA:
undetectable		 3jw5A-5gncA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 7 TRP A 572
LEU A 623
LEU A 607
ILE A 563
 None
 1.02A 3u5jA-5gncA:
undetectable		 3u5jA-5gncA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 3wg7N-5gncA:
undetectable
3wg7W-5gncA:
undetectable		 3wg7N-5gncA:
21.10
3wg7W-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5gnc AVH146
(Phytophthora
sojae) 		3 / 3 PHE A 460
ASP A 458
ARG A 505
 None
 0.85A 4eahF-5gncA:
undetectable		 4eahF-5gncA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5gnc AVH146
(Phytophthora
sojae) 		3 / 3 PHE A 460
ASP A 458
ARG A 505
 None
 0.84A 4eahG-5gncA:
undetectable		 4eahG-5gncA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5gnc AVH146
(Phytophthora
sojae) 		5 / 9 THR A 392
LEU A 389
ALA A 407
LEU A 445
PHE A 411
 None
 1.38A 4ltwA-5gncA:
undetectable		 4ltwA-5gncA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5gnc AVH146
(Phytophthora
sojae) 		3 / 3 TRP A 297
GLN A 239
THR A 296
 None
 1.01A 4m2xA-5gncA:
undetectable		 4m2xA-5gncA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 7 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 5b3sN-5gncA:
2.1
5b3sW-5gncA:
undetectable		 5b3sN-5gncA:
21.10
5b3sW-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 7 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.91A 5iy5N-5gncA:
2.0
5iy5W-5gncA:
undetectable		 5iy5N-5gncA:
21.10
5iy5W-5gncA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 5 ALA A 163
ALA A 153
ILE A 150
LEU A 146
 None
 0.81A 5jncD-5gncA:
undetectable		 5jncD-5gncA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5gnc AVH146
(Phytophthora
sojae) 		5 / 12 LEU A 528
MET A 515
LEU A 516
LEU A 512
LEU A 465
 None
 1.24A 5toaB-5gncA:
undetectable		 5toaB-5gncA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 5 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.92A 5x1fW-5gncA:
undetectable		 5x1fW-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 5 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 5z86J-5gncA:
undetectable		 5z86J-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 5z86N-5gncA:
2.1
5z86W-5gncA:
undetectable		 5z86N-5gncA:
21.10
5z86W-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 TYR A 232
MET A 228
THR A 227
LEU A 224
 None
 0.94A 5zcoN-5gncA:
2.0
5zcoW-5gncA:
undetectable		 5zcoN-5gncA:
21.10
5zcoW-5gncA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5gnc AVH146
(Phytophthora
sojae) 		5 / 10 LEU A 477
VAL A 468
PHE A 460
MET A 515
THR A 511
 None
 1.49A 6b4yA-5gncA:
undetectable		 6b4yA-5gncA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5gnc AVH146
(Phytophthora
sojae) 		3 / 3 ALA A 366
PHE A 353
GLN A 349
 None
 0.82A 6eceA-5gncA:
undetectable		 6eceA-5gncA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5gnc AVH146
(Phytophthora
sojae) 		4 / 6 LEU A 623
ALA A 626
LEU A 573
ASN A 580
 None
 0.85A 6f88B-5gncA:
undetectable		 6f88B-5gncA:
8.85