SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		3 / 3 THR A 321
PRO A 327
THR A 326
 None
 0.89A 1a7yB-5gneA:
undetectable		 1a7yB-5gneA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		3 / 3 THR A 321
PRO A 327
THR A 326
 None
 0.95A 1dscC-5gneA:
undetectable		 1dscC-5gneA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 11 ILE A 252
MET A 285
MET A 237
VAL A 241
LEU A 319
 None
 0.90A 1dtlA-5gneA:
undetectable		 1dtlA-5gneA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 9 ALA A 355
ASN A 140
SER A 232
ILE A 231
THR A 356
 None
 1.49A 1j3jB-5gneA:
undetectable		 1j3jB-5gneA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 6 GLU A 158
SER A 153
ARG A 149
TYR A 146
 None
 1.43A 1tufA-5gneA:
undetectable
1tufB-5gneA:
undetectable		 1tufA-5gneA:
23.29
1tufB-5gneA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 4 LEU A  38
SER A  35
TYR A  39
LEU A  42
 None
 1.26A 1xz1A-5gneA:
undetectable		 1xz1A-5gneA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 4 LEU A  38
SER A  35
TYR A  39
LEU A  42
 None
 1.28A 1xz3A-5gneA:
undetectable		 1xz3A-5gneA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 12 LEU A 217
ASP A 215
PHE A 190
THR A  67
TYR A  80
 None
 1.31A 2oipB-5gneA:
undetectable		 2oipB-5gneA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 ILE A 210
LEU A 248
LEU A 388
GLY A 387
 None
 0.97A 2qqcD-5gneA:
undetectable
2qqcE-5gneA:
undetectable		 2qqcD-5gneA:
14.71
2qqcE-5gneA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 6 GLU A 393
TYR A 323
LYS A 115
PRO A 117
 None
 1.18A 2vmyA-5gneA:
undetectable		 2vmyA-5gneA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 12 LEU A 235
LEU A 287
GLY A 211
LEU A 143
VAL A 270
 None
 1.35A 2w8yA-5gneA:
undetectable		 2w8yA-5gneA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 9 GLY A  78
LEU A 264
ILE A  32
LEU A  81
ALA A 336
 None
 0.89A 2z0yA-5gneA:
undetectable		 2z0yA-5gneA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 9 GLY A  78
LEU A 264
ILE A  32
LEU A  81
ALA A 336
 None
 0.83A 2z0yB-5gneA:
undetectable		 2z0yB-5gneA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 GLU A 261
GLU A 260
ARG A  74
SER A 338
 ZN  A 401 (-2.6A)
ZN  A 402 ( 3.7A)
ZN  A 401 ( 3.7A)
ZN  A 402 ( 4.8A)
 1.13A 2zt7A-5gneA:
undetectable		 2zt7A-5gneA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 12 ALA A 256
GLU A 260
THR A 344
VAL A 308
THR A 350
 None
ZN  A 402 ( 3.7A)
None
None
None
 1.09A 3c6gB-5gneA:
undetectable		 3c6gB-5gneA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 10 ASP A 339
SER A 267
GLY A 263
ARG A  74
ASP A 226
 None
None
None
ZN  A 401 ( 3.7A)
ZN  A 402 ( 2.8A)
 1.34A 3n2oC-5gneA:
undetectable
3n2oD-5gneA:
undetectable		 3n2oC-5gneA:
21.35
3n2oD-5gneA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 9 ALA A 224
ASP A 225
ILE A 374
ILE A 136
LEU A 372
 None
 1.04A 3ogpB-5gneA:
undetectable		 3ogpB-5gneA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 4 ASP A 227
ASP A 288
GLY A 211
THR A 351
 ZN  A 402 ( 4.8A)
ZN  A 402 (-1.9A)
None
None
 1.35A 3tl9B-5gneA:
undetectable		 3tl9B-5gneA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 10 ILE A 265
ASP A 215
PHE A 190
THR A  67
TYR A  80
 None
 1.32A 3um5B-5gneA:
undetectable		 3um5B-5gneA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 TYR A 352
HIS A 213
HIS A 366
HIS A 340
 None
ZN  A 402 (-3.4A)
ZN  A 401 (-3.7A)
None
 1.35A 3zodA-5gneA:
undetectable		 3zodA-5gneA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 LEU A 375
ASP A 225
SER A 229
HIS A 379
 None
 1.18A 4aq7A-5gneA:
undetectable		 4aq7A-5gneA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 LEU A 264
TYR A 257
SER A 338
HIS A 340
 None
None
ZN  A 402 ( 4.8A)
None
 1.11A 4arcA-5gneA:
undetectable		 4arcA-5gneA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 4 TRP A 162
LEU A 235
LEU A 170
THR A 169
 None
 1.14A 4bboD-5gneA:
undetectable		 4bboD-5gneA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 LEU A 287
THR A 384
ILE A 136
GLY A 291
 None
 0.95A 4eqlB-5gneA:
undetectable		 4eqlB-5gneA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 ASP A 226
GLU A 261
HIS A 366
GLU A 260
 ZN  A 402 ( 2.8A)
ZN  A 401 (-2.6A)
ZN  A 401 (-3.7A)
ZN  A 402 ( 3.7A)
 1.04A 4hvrA-5gneA:
undetectable		 4hvrA-5gneA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 6 GLU A 261
GLU A 260
ARG A  74
SER A 338
 ZN  A 401 (-2.6A)
ZN  A 402 ( 3.7A)
ZN  A 401 ( 3.7A)
ZN  A 402 ( 4.8A)
 1.37A 4kr3A-5gneA:
2.3		 4kr3A-5gneA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 LEU A 287
THR A 384
ILE A 136
GLY A 291
 None
 0.91A 4l39B-5gneA:
undetectable		 4l39B-5gneA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 7 ASP A 339
GLN A 286
PRO A 353
ILE A 214
 None
 1.04A 4pcuA-5gneA:
undetectable		 4pcuA-5gneA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		6 / 11 HIS A 213
ASP A 226
GLU A 260
GLU A 261
ASN A 362
HIS A 366
 ZN  A 402 (-3.4A)
ZN  A 402 ( 2.8A)
ZN  A 402 ( 3.7A)
ZN  A 401 (-2.6A)
None
ZN  A 401 (-3.7A)
 1.23A 4pqaA-5gneA:
24.0		 4pqaA-5gneA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 11 HIS A 213
GLU A 260
GLU A 261
GLY A 334
HIS A 366
 ZN  A 402 (-3.4A)
ZN  A 402 ( 3.7A)
ZN  A 401 (-2.6A)
None
ZN  A 401 (-3.7A)
 0.82A 4pqaA-5gneA:
24.0		 4pqaA-5gneA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		3 / 3 SER A 338
TYR A 352
ASP A 226
 ZN  A 402 ( 4.8A)
None
ZN  A 402 ( 2.8A)
 0.80A 4rp8C-5gneA:
undetectable		 4rp8C-5gneA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		6 / 10 LEU A 287
GLY A 230
ASN A 140
SER A 228
ALA A 238
ILE A 210
 None
 1.39A 4xj7C-5gneA:
3.0
4xj7D-5gneA:
3.1		 4xj7C-5gneA:
20.05
4xj7D-5gneA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 11 SER A 229
LEU A  70
ASP A 370
GLY A 223
MET A 221
 None
 1.30A 4zjqA-5gneA:
0.4		 4zjqA-5gneA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		6 / 12 ILE A 214
GLY A 156
ALA A 160
PHE A 183
ILE A 255
ALA A 256
 None
 1.28A 5n0tB-5gneA:
undetectable		 5n0tB-5gneA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		5 / 12 ASN A 188
GLN A  88
SER A 267
GLY A 268
GLN A  89
 None
 1.46A 5oj0A-5gneA:
undetectable		 5oj0A-5gneA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5gne LEUCINE
AMINOPEPTIDASE
(Legionella
pneumophila) 		4 / 5 THR A 367
THR A 356
GLN A 289
ASP A 359
 None
 1.47A 6ecxA-5gneA:
undetectable		 6ecxA-5gneA:
21.77