SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gnm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 8 MET A 398
GLU A 140
ASP A 136
ARG A 393
 None
 1.24A 1dtlA-5gnmA:
undetectable		 1dtlA-5gnmA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 9 ALA A 272
PHE A 276
GLY A 357
LEU A 262
PHE A 365
 None
 1.12A 1nr6A-5gnmA:
26.9		 1nr6A-5gnmA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		3 / 3 PRO A  24
ASN A  21
ARG A 389
 None
 1.02A 2qeuB-5gnmA:
undetectable		 2qeuB-5gnmA:
17.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 LYS A 180
ASN A 181
ILE A 235
ALA A 236
THR A 240
 None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
 1.10A 3a50A-5gnmA:
56.7		 3a50A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 12 PRO A  83
THR A  84
MET A  86
ILE A  88
ILE A 235
ALA A 236
LEU A 387
 None
None
None
HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.6A)
None
 0.85A 3a50A-5gnmA:
56.7		 3a50A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		8 / 12 PRO A  83
THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
ALA A 236
THR A 240
 None
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
 0.64A 3a50A-5gnmA:
56.7		 3a50A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 11 THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
PRO A 287
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-3.5A)
 0.54A 3a50B-5gnmA:
56.5		 3a50B-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 11 THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
 0.43A 3a50C-5gnmA:
56.6		 3a50C-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 LEU A 171
ASN A 181
MET A 184
ILE A 235
ALA A 236
THR A 240
 None
None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
 1.40A 3a50D-5gnmA:
56.8		 3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 LEU A 171
LYS A 180
ASN A 181
MET A 184
ALA A 236
THR A 240
 None
None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
 1.37A 3a50D-5gnmA:
56.8		 3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 PRO A  83
MET A  86
ILE A  88
LEU A  89
ILE A 235
LEU A 387
 None
None
HEM  A 501 ( 4.4A)
None
None
None
 0.81A 3a50D-5gnmA:
56.8		 3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 PRO A  83
MET A  86
ILE A  88
LEU A  89
ILE A 235
THR A 240
 None
None
HEM  A 501 ( 4.4A)
None
None
HEM  A 501 (-3.7A)
 0.42A 3a50D-5gnmA:
56.8		 3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 PRO A  83
MET A  86
LEU A  89
ILE A 235
ALA A 236
LEU A 387
 None
None
None
None
HEM  A 501 (-3.6A)
None
 0.94A 3a50D-5gnmA:
56.8		 3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 PRO A  83
MET A  86
LEU A  89
ILE A 235
ALA A 236
THR A 240
 None
None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
 0.73A 3a50D-5gnmA:
56.8		 3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 12 PRO A  83
THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
 None
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
 0.44A 3a50E-5gnmA:
56.5		 3a50E-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 PRO A  83
THR A  84
MET A  86
ILE A  88
LEU A 387
 None
None
None
HEM  A 501 ( 4.4A)
None
 0.87A 3a50E-5gnmA:
56.5		 3a50E-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 11 ILE A  88
ILE A 235
THR A 240
VAL A 283
PRO A 287
LEU A 387
 HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
None
 0.79A 3a51A-5gnmA:
56.7		 3a51A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		8 / 11 THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
VAL A 283
PRO A 287
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
 0.55A 3a51A-5gnmA:
56.7		 3a51A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 12 PRO A  83
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
LEU A 387
 None
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
None
 0.84A 3a51B-5gnmA:
56.4		 3a51B-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		8 / 12 PRO A  83
THR A  84
MET A  86
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
 None
None
None
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
 0.59A 3a51B-5gnmA:
56.4		 3a51B-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 12 ILE A  88
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
LEU A 387
 HEM  A 501 ( 4.4A)
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
None
 0.81A 3a51C-5gnmA:
56.6		 3a51C-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		8 / 12 THR A  84
MET A  86
ILE A  88
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
 None
None
HEM  A 501 ( 4.4A)
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
 0.59A 3a51C-5gnmA:
56.6		 3a51C-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 ILE A  88
ASN A 181
MET A 184
LEU A 232
VAL A 283
 HEM  A 501 ( 4.4A)
None
None
HEM  A 501 ( 4.7A)
HEM  A 501 (-4.7A)
 1.00A 3a51D-5gnmA:
56.7		 3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 ILE A  88
MET A 184
LEU A 232
VAL A 283
PRO A 287
 HEM  A 501 ( 4.4A)
None
HEM  A 501 ( 4.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
 0.94A 3a51D-5gnmA:
56.7		 3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 12 MET A  86
ILE A  88
ASN A 181
LEU A 232
ILE A 235
THR A 240
VAL A 283
 None
HEM  A 501 ( 4.4A)
None
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
 1.28A 3a51D-5gnmA:
56.7		 3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 12 THR A  84
MET A  86
ILE A  88
ILE A 235
THR A 240
PRO A 287
LEU A 387
 None
None
HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-3.5A)
None
 0.90A 3a51D-5gnmA:
56.7		 3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		8 / 12 THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
VAL A 283
PRO A 287
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
 0.61A 3a51D-5gnmA:
56.7		 3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		7 / 12 THR A  84
MET A  86
ILE A  88
ILE A 235
THR A 240
VAL A 283
PRO A 287
 None
None
HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
 0.66A 3a51E-5gnmA:
56.4		 3a51E-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 THR A  84
MET A  86
ILE A 235
ALA A 236
THR A 240
VAL A 283
 None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
 0.95A 3a51E-5gnmA:
56.4		 3a51E-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 6 ARG A  36
LEU A  38
PHE A  14
LEU A  13
 None
 1.00A 3abkP-5gnmA:
undetectable
3abkW-5gnmA:
undetectable		 3abkP-5gnmA:
21.04
3abkW-5gnmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 VAL A 308
PHE A  14
PHE A  18
LEU A  13
ALA A 314
 None
 1.42A 3apvA-5gnmA:
undetectable		 3apvA-5gnmA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 VAL A 308
PHE A  14
PHE A  18
LEU A  13
ALA A 314
 None
 1.42A 3apvB-5gnmA:
undetectable		 3apvB-5gnmA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		3 / 3 ALA A 236
THR A 240
CYH A 347
 HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.6A)
 0.53A 3e4eA-5gnmA:
29.8		 3e4eA-5gnmA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		3 / 3 ALA A 236
THR A 240
CYH A 347
 HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
HEM  A 501 (-2.6A)
 0.46A 3e4eB-5gnmA:
29.7		 3e4eB-5gnmA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		3 / 3 ALA A  57
ARG A 289
LYS A  65
 None
HEM  A 501 (-2.7A)
HEM  A 501 (-2.6A)
 0.85A 3kp3B-5gnmA:
undetectable		 3kp3B-5gnmA:
15.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 10 LEU A 232
ILE A 235
ALA A 236
THR A 240
VAL A 283
 HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
 1.14A 3r9cA-5gnmA:
41.7		 3r9cA-5gnmA:
39.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		8 / 12 PRO A  83
ILE A  88
LEU A 232
ILE A 235
ALA A 236
PRO A 287
ILE A 288
LEU A 387
 None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.5A)
None
None
 0.89A 3vrmA-5gnmA:
55.3		 3vrmA-5gnmA:
99.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		8 / 12 PRO A  83
MET A  86
ILE A  88
LEU A 232
ILE A 235
ALA A 236
PRO A 287
ILE A 288
 None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.5A)
None
 0.75A 3vrmA-5gnmA:
55.3		 3vrmA-5gnmA:
99.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 7 LEU A 391
TYR A 382
ARG A 389
GLY A 248
 None
 0.79A 4eq4A-5gnmA:
undetectable		 4eq4A-5gnmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 7 LEU A 391
TYR A 382
ARG A 389
GLY A 248
 None
 0.74A 4eqlA-5gnmA:
undetectable		 4eqlA-5gnmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 7 LEU A 391
TYR A 382
ARG A 389
GLY A 248
 None
 0.75A 4eqlB-5gnmA:
undetectable		 4eqlB-5gnmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		3 / 3 ASP A  66
ARG A  68
ASP A  94
 None
 0.69A 4fzvA-5gnmA:
undetectable		 4fzvA-5gnmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 LEU A 312
TRP A  19
PHE A  14
PHE A  18
THR A 386
 None
 1.30A 4iaqA-5gnmA:
undetectable		 4iaqA-5gnmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		3 / 3 LEU A 233
MET A 229
ASP A 204
 HEM  A 501 (-4.4A)
None
None
 0.80A 4j7xB-5gnmA:
undetectable		 4j7xB-5gnmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 10 ILE A  88
ILE A 235
ALA A 236
THR A 240
VAL A 283
 HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
 1.03A 4kq8A-5gnmA:
28.5		 4kq8A-5gnmA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 10 ILE A 235
ALA A 236
THR A 240
VAL A 283
MET A 309
 None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
None
 0.86A 4kq8A-5gnmA:
28.5		 4kq8A-5gnmA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 6 LEU A 391
TYR A 382
ARG A 389
GLY A 248
 None
 0.70A 4l39A-5gnmA:
undetectable		 4l39A-5gnmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 7 LEU A 391
TYR A 382
ARG A 389
GLY A 248
 None
 0.78A 4l39B-5gnmA:
undetectable		 4l39B-5gnmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 7 SER A 222
GLU A 224
ASP A  94
THR A  82
 None
 1.19A 4uacA-5gnmA:
undetectable		 4uacA-5gnmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 6 ARG A 289
HIS A  95
ARG A  99
ILE A 344
 HEM  A 501 (-2.7A)
HEM  A 501 (-4.2A)
HEM  A 501 (-4.1A)
None
 1.37A 5a06A-5gnmA:
undetectable		 5a06A-5gnmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 PRO A 282
LEU A 277
VAL A 242
LEU A 364
MET A 138
 HEM  A 501 ( 4.4A)
None
None
None
None
 1.14A 5bykA-5gnmA:
undetectable		 5bykA-5gnmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 5 ILE A 330
LEU A 364
GLY A 362
PHE A 365
 None
 0.95A 5kmdC-5gnmA:
undetectable
5kmdD-5gnmA:
1.5		 5kmdC-5gnmA:
20.48
5kmdD-5gnmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 5 ARG A  36
LEU A  38
PHE A  14
LEU A  13
 None
 0.97A 5x19C-5gnmA:
undetectable
5x19J-5gnmA:
undetectable		 5x19C-5gnmA:
21.04
5x19J-5gnmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 5 ARG A  36
LEU A  38
PHE A  14
LEU A  13
 None
 1.04A 5x1bP-5gnmA:
undetectable		 5x1bP-5gnmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 5 LEU A  63
PHE A 290
LEU A 310
PHE A  58
 None
None
None
HEM  A 501 (-4.8A)
 1.20A 5x1fC-5gnmA:
undetectable
5x1fJ-5gnmA:
undetectable		 5x1fC-5gnmA:
21.04
5x1fJ-5gnmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 12 LEU A 126
GLY A 124
THR A 131
ALA A 360
VAL A 359
 None
 1.07A 5x66F-5gnmA:
undetectable		 5x66F-5gnmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		6 / 12 PRO A 282
LEU A 277
VAL A 242
LEU A 364
MET A 138
LEU A 137
 HEM  A 501 ( 4.4A)
None
None
None
None
None
 1.28A 6b52A-5gnmA:
undetectable		 6b52A-5gnmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		4 / 5 VAL A 308
TRP A  46
PRO A  44
THR A 301
 None
 1.48A 6cduI-5gnmA:
undetectable
6cduJ-5gnmA:
undetectable		 6cduI-5gnmA:
21.57
6cduJ-5gnmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5gnm VITAMIN D(3)
25-HYDROXYLASE
(Pseudonocardia
autotrophica) 		5 / 10 VAL A 396
LEU A 371
LEU A 364
LEU A 252
LEU A 253
 None
 0.98A 6f6nA-5gnmA:
undetectable
6f6nB-5gnmA:
undetectable		 6f6nA-5gnmA:
13.96
6f6nB-5gnmA:
11.40