SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 4 LEU C 237
PRO C 238
LEU C 233
ARG C  42
 None
 1.42A 1hrkB-5gnwC:
2.9		 1hrkB-5gnwC:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.06A 1pxxC-5gnwC:
undetectable		 1pxxC-5gnwC:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 ALA C 134
PHE C  80
GLN C  78
LEU C  69
ARG C  42
 None
None
None
URA  C 301 (-3.9A)
None
 1.35A 1u70A-5gnwC:
undetectable		 1u70A-5gnwC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 4 LEU C 237
PRO C 238
LEU C 233
ARG C  42
 None
 1.44A 2pnjB-5gnwC:
2.9		 2pnjB-5gnwC:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU C 225
GLY C  79
LEU C 190
PHE C 220
MET C 189
 None
 1.32A 3h52C-5gnwC:
undetectable		 3h52C-5gnwC:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU C 127
PHE C 123
ALA C 134
ILE C  86
GLY C  43
 None
 1.02A 3nxuA-5gnwC:
undetectable		 3nxuA-5gnwC:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 TYR C 118
GLY C 114
ALA C  26
PHE C  96
CYH C  18
 None
 1.23A 3s8pA-5gnwC:
undetectable		 3s8pA-5gnwC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 TYR C 118
GLY C 114
ALA C  26
PHE C  96
CYH C  18
 None
 1.23A 3s8pB-5gnwC:
undetectable		 3s8pB-5gnwC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		3 / 3 ARG C 242
GLU C   4
THR C   3
 None
 0.89A 3v4tA-5gnwC:
undetectable		 3v4tA-5gnwC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 TYR C 118
GLY C 114
ALA C  26
PHE C  96
CYH C  18
 None
 1.22A 4bupB-5gnwC:
undetectable		 4bupB-5gnwC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.14A 4coxA-5gnwC:
undetectable		 4coxA-5gnwC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.14A 4coxB-5gnwC:
undetectable		 4coxB-5gnwC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.14A 4coxD-5gnwC:
0.4		 4coxD-5gnwC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		3 / 3 TYR C  90
ARG C  44
SER C  89
 None
 1.18A 4dr2I-5gnwC:
undetectable
4dr2J-5gnwC:
undetectable		 4dr2I-5gnwC:
21.69
4dr2J-5gnwC:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 8 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.54A 4wryA-5gnwC:
8.5		 4wryA-5gnwC:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 8 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.52A 4wrzA-5gnwC:
8.4		 4wrzA-5gnwC:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 7 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.59A 4ws0A-5gnwC:
8.0		 4ws0A-5gnwC:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		4 / 8 GLY C  55
GLN C  56
ASN C  94
HIS C 168
 URA  C 301 ( 3.9A)
None
URA  C 301 (-2.9A)
URA  C 301 (-3.6A)
 0.56A 4ws1A-5gnwC:
7.9		 4ws1A-5gnwC:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 TYR C 118
GLY C 114
ALA C  26
PHE C  96
CYH C  18
 None
 1.28A 5cprB-5gnwC:
undetectable		 5cprB-5gnwC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL C 100
TYR C  27
LEU C  69
GLY C  55
LEU C 141
 None
None
URA  C 301 (-3.9A)
URA  C 301 ( 3.9A)
None
 1.04A 5iktA-5gnwC:
undetectable		 5iktA-5gnwC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 TYR C 118
GLY C 114
ALA C  26
PHE C  96
CYH C  18
 None
 1.17A 5wbvA-5gnwC:
undetectable		 5wbvA-5gnwC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		5 / 12 TYR C 118
GLY C 114
ALA C  26
PHE C  96
CYH C  18
 None
 1.17A 5wbvB-5gnwC:
undetectable		 5wbvB-5gnwC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		3 / 3 THR C  95
ALA C 145
LYS C 147
 None
 0.34A 6fgcA-5gnwC:
3.2		 6fgcA-5gnwC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		3 / 3 THR C  95
ALA C 145
LYS C 147
 None
 0.39A 6fgdA-5gnwC:
3.2		 6fgdA-5gnwC:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 5gnw BLR0248 PROTEIN
(Bradyrhizobium
diazoefficiens) 		3 / 3 ARG C  15
GLY C  10
GLU C  11
 None
 0.54A 6fgdA-5gnwC:
undetectable		 6fgdA-5gnwC:
21.73