SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 11 LEU C 327
VAL C 287
ILE C 106
GLU C 128
PHE C 334
 None
 1.39A 1gx9A-5gp4C:
undetectable		 1gx9A-5gp4C:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 ASP C 177
ASP C 179
LYS C 138
 None
 1.12A 1lqtB-5gp4C:
undetectable		 1lqtB-5gp4C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 ASP C 177
ASP C 179
LYS C 138
 None
 1.12A 1lquB-5gp4C:
undetectable		 1lquB-5gp4C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 LEU C 198
ASN C 269
ILE C 243
ASP C 227
 None
 0.96A 1yc2E-5gp4C:
2.4		 1yc2E-5gp4C:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 251
ALA C 247
ASP C 246
GLY C 288
ILE C 273
 None
None
PLP  C 501 (-2.7A)
None
None
 0.90A 2hs2A-5gp4C:
undetectable		 2hs2A-5gp4C:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 ALA C 248
GLY C 251
SER C 126
LEU C 223
LEU C 226
 PLP  C 501 (-3.1A)
None
PLP  C 501 (-4.2A)
None
None
 1.09A 2hw2A-5gp4C:
undetectable		 2hw2A-5gp4C:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 5 TRP C 110
ALA C 247
LEU C 109
ALA C 275
 None
 1.22A 2jstA-5gp4C:
undetectable
2jstB-5gp4C:
undetectable		 2jstA-5gp4C:
8.41
2jstB-5gp4C:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 PRO C 184
MET C 185
HIS C 189
ASP C 222
 None
 1.28A 2lh8A-5gp4C:
undetectable		 2lh8A-5gp4C:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.87A 2pxcA-5gp4C:
undetectable		 2pxcA-5gp4C:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 GLY C 250
TYR C 280
SER C 249
 None
None
PLP  C 501 ( 4.6A)
 0.77A 2xatA-5gp4C:
0.6		 2xatA-5gp4C:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 LYS C 305
LYS C 300
VAL C 303
 None
 0.91A 3brfA-5gp4C:
undetectable		 3brfA-5gp4C:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 9 ASP C 371
ILE C 378
GLY C 218
ILE C 214
ILE C 369
 None
 1.25A 3ekyB-5gp4C:
undetectable		 3ekyB-5gp4C:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 10 ILE C 106
ILE C 105
GLY C 338
PHE C 337
VAL C 283
 None
 1.26A 3elzB-5gp4C:
undetectable		 3elzB-5gp4C:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 ALA C 248
GLY C 251
TRP C 289
GLY C 213
HIS C 244
 PLP  C 501 (-3.1A)
None
None
None
None
 1.03A 3ou6B-5gp4C:
undetectable		 3ou6B-5gp4C:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 ALA C 248
GLY C 251
TRP C 289
GLY C 213
HIS C 244
 PLP  C 501 (-3.1A)
None
None
None
None
 1.07A 3ou7B-5gp4C:
undetectable		 3ou7B-5gp4C:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.87A 3p97A-5gp4C:
undetectable		 3p97A-5gp4C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 HIS C 196
SER C 162
ASN C 414
 None
 0.75A 3s8pB-5gp4C:
undetectable		 3s8pB-5gp4C:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 9 ILE C 438
LEU C 441
ILE C 378
PHE C 366
GLY C 365
 None
 1.25A 3sj4X-5gp4C:
undetectable		 3sj4X-5gp4C:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 VAL C 209
TRP C 169
HIS C 244
PHE C 172
 None
 1.46A 3v35A-5gp4C:
undetectable		 3v35A-5gp4C:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 VAL C 194
TYR C 200
VAL C 229
ILE C 208
 None
 0.97A 4aftD-5gp4C:
undetectable
4aftE-5gp4C:
undetectable		 4aftD-5gp4C:
18.68
4aftE-5gp4C:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 TRP C 110
TRP C 263
THR C 254
 None
 1.43A 4bboB-5gp4C:
undetectable		 4bboB-5gp4C:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 TYR C 253
THR C 361
LEU C 368
THR C 217
 None
 1.10A 4mbsA-5gp4C:
undetectable		 4mbsA-5gp4C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 5 TYR C 253
THR C 361
LEU C 368
THR C 217
 None
 1.09A 4mbsB-5gp4C:
undetectable		 4mbsB-5gp4C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 5 TYR C 280
THR C 361
LEU C 368
THR C 217
 None
 1.34A 4mbsB-5gp4C:
undetectable		 4mbsB-5gp4C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 ILE C 291
ILE C 273
ALA C 247
TRP C 289
 None
 0.98A 4ou1A-5gp4C:
undetectable		 4ou1A-5gp4C:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 MET C 185
MET C 212
TYR C 216
 None
 1.43A 4p6xI-5gp4C:
undetectable		 4p6xI-5gp4C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 ASP C  45
ARG C  46
GLU C  25
ARG C  42
 None
 1.30A 4qyqC-5gp4C:
0.3		 4qyqC-5gp4C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 PHE C 265
ALA C 224
ILE C 271
ASN C 269
ASP C 264
 None
 1.23A 4rtpA-5gp4C:
3.2		 4rtpA-5gp4C:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 LEU C 298
ALA C 317
LEU C 132
LEU C 135
 None
 0.84A 4ubsA-5gp4C:
undetectable		 4ubsA-5gp4C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		3 / 3 HIS C 196
SER C 162
ASN C 414
 None
 0.82A 5cprB-5gp4C:
undetectable		 5cprB-5gp4C:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 PHE C  65
SER C 276
ALA C 248
HIS C 278
 None
PLP  C 501 (-2.7A)
PLP  C 501 (-3.1A)
PLP  C 501 (-3.8A)
 1.14A 5dzkB-5gp4C:
undetectable
5dzkP-5gp4C:
undetectable		 5dzkB-5gp4C:
17.12
5dzkP-5gp4C:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 PHE C  65
SER C 276
ALA C 248
HIS C 278
 None
PLP  C 501 (-2.7A)
PLP  C 501 (-3.1A)
PLP  C 501 (-3.8A)
 1.13A 5dzkg-5gp4C:
undetectable
5dzku-5gp4C:
undetectable		 5dzkg-5gp4C:
17.12
5dzku-5gp4C:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.88A 5ec8A-5gp4C:
undetectable		 5ec8A-5gp4C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.87A 5ehgC-5gp4C:
undetectable		 5ehgC-5gp4C:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 6 ASP C  45
ARG C  46
GLU C  25
ARG C  42
 None
 1.30A 5hpwC-5gp4C:
0.3		 5hpwC-5gp4C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5ikmA-5gp4C:
undetectable		 5ikmA-5gp4C:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5kqsA-5gp4C:
undetectable		 5kqsA-5gp4C:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5m5bA-5gp4C:
undetectable		 5m5bA-5gp4C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 8 LEU C 198
GLU C 231
ASN C 234
ILE C 243
 None
 0.66A 5mzjA-5gp4C:
undetectable		 5mzjA-5gp4C:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.85A 5njvA-5gp4C:
2.1		 5njvA-5gp4C:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5njvB-5gp4C:
undetectable		 5njvB-5gp4C:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.84A 5njvC-5gp4C:
undetectable		 5njvC-5gp4C:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.87A 5vimA-5gp4C:
undetectable		 5vimA-5gp4C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.85A 5vimB-5gp4C:
undetectable		 5vimB-5gp4C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5wz1A-5gp4C:
undetectable		 5wz1A-5gp4C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5wz1C-5gp4C:
undetectable		 5wz1C-5gp4C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5wz1E-5gp4C:
undetectable		 5wz1E-5gp4C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.88A 5wz2A-5gp4C:
undetectable		 5wz2A-5gp4C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.86A 5wz2B-5gp4C:
undetectable		 5wz2B-5gp4C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		5 / 12 GLY C 288
GLY C 329
GLY C 277
TRP C 289
ILE C 328
 None
 0.88A 5wz2C-5gp4C:
undetectable		 5wz2C-5gp4C:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 PHE C  65
ALA C 248
ALA C 247
THR C 254
 None
PLP  C 501 (-3.1A)
None
None
 0.87A 6a7jA-5gp4C:
undetectable		 6a7jA-5gp4C:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5gp4 GLUTAMATE
DECARBOXYLASE
(Lactobacillus
brevis) 		4 / 7 PHE C 334
LEU C 109
GLY C 251
GLY C 125
 None
None
None
PLP  C 501 (-3.6A)
 0.80A 6eu9D-5gp4C:
undetectable		 6eu9D-5gp4C:
12.05