SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 860
LEU A 790
PHE A 791
LEU A 787
 None
 0.98A 1e7cA-5gpdA:
3.2		 1e7cA-5gpdA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A 785
ASN A 786
SER A 788
THR A 827
 None
 0.98A 1h7xA-5gpdA:
undetectable		 1h7xA-5gpdA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A 785
ASN A 786
SER A 788
THR A 827
 None
 1.00A 1h7xB-5gpdA:
undetectable		 1h7xB-5gpdA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A 785
ASN A 786
SER A 788
THR A 827
 None
 1.00A 1h7xC-5gpdA:
undetectable		 1h7xC-5gpdA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE A 785
ASN A 786
SER A 788
THR A 827
 None
 1.00A 1h7xD-5gpdA:
undetectable		 1h7xD-5gpdA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 793
SER A 685
LEU A 829
LEU A 744
 None
 1.05A 1yajA-5gpdA:
undetectable		 1yajA-5gpdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 793
SER A 685
LEU A 829
LEU A 744
 None
 0.96A 1yajD-5gpdA:
undetectable		 1yajD-5gpdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 THR A 863
ALA A 837
TYR A 814
PHE A 791
 None
 1.04A 2hzqA-5gpdA:
undetectable		 2hzqA-5gpdA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 744
LEU A 747
LEU A 799
SER A 795
 None
 0.87A 3vhuA-5gpdA:
undetectable		 3vhuA-5gpdA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 12 ASP A 689
ASP A 655
ASN A 651
SER A 737
HIS A 741
 None
 1.49A 4feuA-5gpdA:
undetectable
4feuB-5gpdA:
1.0		 4feuA-5gpdA:
22.04
4feuB-5gpdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A 795
THR A 792
THR A 836
ALA A 837
THR A 840
 None
 1.37A 5d0xH-5gpdA:
undetectable
5d0xI-5gpdA:
undetectable		 5d0xH-5gpdA:
22.14
5d0xI-5gpdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 10 PRO A 733
ILE A 738
ILE A 729
ILE A 728
ILE A 725
 None
 0.92A 5murE-5gpdA:
undetectable		 5murE-5gpdA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A 844
SER A 757
ILE A 832
LEU A 799
ALA A 800
 None
 1.24A 5oy02-5gpdA:
undetectable		 5oy02-5gpdA:
13.55