SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		4 / 8 SER A 256
THR A 226
ASN A 151
LEU A 248
 None
 0.91A 1lhvA-5gppA:
undetectable		 1lhvA-5gppA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		4 / 7 SER A 115
ILE A 236
ILE A 117
THR A 246
 None
 0.95A 1sbrB-5gppA:
undetectable		 1sbrB-5gppA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		5 / 12 ILE A 109
LEU A 263
ILE A  60
VAL A  24
LEU A  21
 None
 1.08A 3a51C-5gppA:
undetectable		 3a51C-5gppA:
24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		9 / 12 ASP A  15
LYS A  16
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
TRP A 231
 MAL  A 501 (-3.4A)
MAL  A 501 (-3.1A)
None
None
MAL  A 501 ( 3.8A)
MAL  A 501 (-3.0A)
MAL  A 501 (-4.2A)
MAL  A 501 (-3.3A)
None
 0.80A 3jyrA-5gppA:
44.2		 3jyrA-5gppA:
78.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		9 / 12 ASP A  15
LYS A  16
GLU A  45
GLU A  46
ALA A  64
ASP A  66
GLU A 112
PRO A 155
TRP A 231
 MAL  A 501 (-3.4A)
MAL  A 501 (-3.1A)
None
None
MAL  A 501 ( 3.8A)
MAL  A 501 (-3.0A)
MAL  A 501 (-3.3A)
MAL  A 501 (-3.8A)
None
 0.64A 3jyrA-5gppA:
44.2		 3jyrA-5gppA:
78.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		10 / 12 ASP A  15
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
TRP A 231
TYR A 342
 MAL  A 501 (-3.4A)
None
None
None
MAL  A 501 ( 3.8A)
MAL  A 501 (-3.0A)
MAL  A 501 (-4.2A)
MAL  A 501 (-3.3A)
None
None
 0.79A 3jyrA-5gppA:
44.2		 3jyrA-5gppA:
78.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		10 / 12 ASP A  15
LYS A  43
GLU A  45
GLU A  46
ALA A  64
ASP A  66
GLU A 112
PRO A 155
TRP A 231
TYR A 342
 MAL  A 501 (-3.4A)
None
None
None
MAL  A 501 ( 3.8A)
MAL  A 501 (-3.0A)
MAL  A 501 (-3.3A)
MAL  A 501 (-3.8A)
None
None
 0.60A 3jyrA-5gppA:
44.2		 3jyrA-5gppA:
78.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		7 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
ARG A 345
 MAL  A 501 ( 4.9A)
MAL  A 501 (-4.8A)
MAL  A 501 (-3.8A)
MAL  A 501 (-4.2A)
MAL  A 501 ( 4.6A)
MAL  A 501 ( 4.0A)
None
 0.60A 3jyrA-5gppA:
44.2		 3jyrA-5gppA:
78.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		5 / 11 GLN A 366
ALA A 365
ALA A 163
GLY A 167
ALA A 189
 None
 0.98A 3mg0V-5gppA:
undetectable
3mg0W-5gppA:
undetectable		 3mg0V-5gppA:
19.12
3mg0W-5gppA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		4 / 5 PHE A 431
ALA A 436
THR A 440
LEU A 423
 None
 1.05A 3t3zC-5gppA:
undetectable		 3t3zC-5gppA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 None
None
None
MAL  A 501 (-3.3A)
None
 0.98A 3tbgD-5gppA:
undetectable		 3tbgD-5gppA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Escherichia
coli;
Danio
rerio) 		3 / 3 ASP A 419
ARG A 355
LYS A 418
 None
 1.28A 3wipG-5gppA:
undetectable		 3wipG-5gppA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Escherichia
coli;
Danio
rerio) 		4 / 7 ILE A  10
LEU A   8
LYS A  27
PHE A  28
 None
 0.99A 4hc3A-5gppA:
undetectable		 4hc3A-5gppA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		5 / 12 LEU A 444
GLU A 462
ALA A 384
PHE A 377
THR A 440
 None
 1.05A 4hytA-5gppA:
undetectable		 4hytA-5gppA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		5 / 12 LEU A 444
GLU A 462
ALA A 384
PHE A 377
THR A 440
 None
 1.05A 4hytC-5gppA:
undetectable		 4hytC-5gppA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		4 / 7 PRO A 332
ALA A 169
LYS A 257
TYR A 156
 None
None
None
MAL  A 501 (-4.2A)
 1.06A 4lb2A-5gppA:
undetectable		 4lb2A-5gppA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Danio
rerio;
Escherichia
coli) 		5 / 12 ILE A 267
ILE A 109
LEU A  21
VAL A  24
ILE A  60
 None
 0.95A 4m2xG-5gppA:
undetectable		 4m2xG-5gppA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Escherichia
coli;
Danio
rerio) 		4 / 4 VAL A 111
ALA A 113
ILE A 318
THR A 321
 None
 1.21A 5e4dB-5gppA:
undetectable		 5e4dB-5gppA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Escherichia
coli;
Danio
rerio) 		5 / 12 GLN A 366
ALA A 365
ALA A 163
GLY A 167
ALA A 189
 None
 0.89A 6hwdH-5gppA:
undetectable
6hwdI-5gppA:
undetectable		 6hwdH-5gppA:
10.53
6hwdI-5gppA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD
(Escherichia
coli;
Danio
rerio) 		5 / 11 GLN A 366
ALA A 365
ALA A 163
GLY A 167
ALA A 189
 None
 0.89A 6hwdV-5gppA:
undetectable		 6hwdV-5gppA:
10.53