SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gpy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 5gpy TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		5 / 12 LEU B 151
ARG B 153
TYR B 143
ILE B 166
GLY B 164
 None
 1.15A 2vufA-5gpyB:
undetectable		 2vufA-5gpyB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		4 / 6 ILE A  28
ILE A  94
LEU B 190
PHE B 202
 None
 1.14A 3adsA-5gpyA:
undetectable		 3adsA-5gpyA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5gpy TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens) 		4 / 4 LEU B 175
LEU B 154
GLN B 179
GLU B 169
 None
 1.27A 4i41A-5gpyB:
undetectable		 4i41A-5gpyB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		3 / 3 LEU A  59
ARG A  56
ARG A  60
 None
 0.81A 4yiaB-5gpyA:
undetectable		 4yiaB-5gpyA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		3 / 3 TYR A  96
LYS A  15
LYS A  10
 None
 1.16A 5dbyA-5gpyA:
undetectable		 5dbyA-5gpyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		4 / 5 PHE A 180
ILE A 184
MET A 110
ARG A 111
 None
 1.11A 5jm4A-5gpyA:
2.6		 5jm4A-5gpyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B 239
LYS B 232
TYR A 105
 None
 1.24A 6gnaA-5gpyB:
undetectable		 6gnaA-5gpyB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B 239
LYS B 232
TYR A 105
 None
 1.24A 6gnbA-5gpyB:
undetectable		 6gnbA-5gpyB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
(Homo
sapiens) 		4 / 7 THR A 175
ARG A 113
HIS A 109
ASP A 117
 None
 1.03A 6mn4E-5gpyA:
undetectable		 6mn4E-5gpyA:
21.43