SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 10 TYR A 179
THR A  90
THR A  86
ALA A  87
TYR A  43
 None
 1.22A 2coiA-5gqqA:
undetectable
2coiB-5gqqA:
undetectable		 2coiA-5gqqA:
19.74
2coiB-5gqqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 10 TYR A  43
TYR A 179
THR A  90
THR A  86
ALA A  87
 None
 1.25A 2coiA-5gqqA:
undetectable
2coiB-5gqqA:
undetectable		 2coiA-5gqqA:
19.74
2coiB-5gqqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens) 		4 / 8 THR A  86
VAL A 183
ASN A 180
ALA A 177
 None
 1.16A 2ij7C-5gqqA:
undetectable		 2ij7C-5gqqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 LEU A  69
ILE A  62
PHE A  66
GLU A 191
LEU A 185
 None
 1.09A 2v0mA-5gqqA:
undetectable		 2v0mA-5gqqA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 LEU A  69
ILE A  62
PHE A  66
GLU A 191
LEU A 185
 None
 1.12A 2v0mD-5gqqA:
undetectable		 2v0mD-5gqqA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 11 ASN A  70
GLY A  65
ALA A 177
GLY A 178
GLU A 191
 None
 1.17A 4a6nA-5gqqA:
undetectable		 4a6nA-5gqqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5gqq HEME-BINDING PROTEIN
2
(Homo
sapiens) 		5 / 12 TYR A 110
GLY A  24
PRO A  45
ALA A  46
GLU A  39
 None
 1.26A 5x6yC-5gqqA:
undetectable		 5x6yC-5gqqA:
12.93