SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 TRP B  68
VAL B  75
TRP B  71
None
1.04A 1c4dA-5gqrB:
undetectable
1c4dB-5gqrB:
undetectable
1c4dA-5gqrB:
3.21
1c4dB-5gqrB:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 LEU B 269
ALA B 246
LEU B 247
ILE B 193
ILE B 241
None
1.05A 1crbA-5gqrB:
undetectable
1crbA-5gqrB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 ILE B 532
LEU B 572
VAL B 591
LEU B 567
ILE B 528
None
0.95A 1df7A-5gqrB:
undetectable
1df7A-5gqrB:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 MET B 374
VAL B 337
GLY B 366
LEU B 389
None
0.98A 1dzmA-5gqrB:
undetectable
1dzmA-5gqrB:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 LEU B 472
LEU B 448
VAL B 446
LEU B 467
ALA B 464
None
1.07A 1gseB-5gqrB:
undetectable
1gseB-5gqrB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 7 PHE B 145
SER B 162
PHE B 141
LEU B 155
None
1.05A 1qcaA-5gqrB:
undetectable
1qcaA-5gqrB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 6 SER B 568
PHE B 613
ASN B 590
ASP B 566
None
1.01A 1yc2A-5gqrB:
undetectable
1yc2A-5gqrB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 5 ILE B 206
ILE B 241
ILE B 193
LEU B 275
None
0.94A 1zgyA-5gqrB:
undetectable
1zgyA-5gqrB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 10 ALA B 246
PHE B 245
LEU B 261
LEU B 217
LEU B 272
None
1.03A 2bxqA-5gqrB:
undetectable
2bxqA-5gqrB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 SER B 495
SER B 497
SER B 473
ASN B 471
None
0.91A 2cmlB-5gqrB:
undetectable
2cmlB-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 SER B 495
SER B 497
SER B 473
GLN B 425
None
1.05A 2cmlC-5gqrB:
undetectable
2cmlC-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 SER B 495
SER B 497
SER B 473
ASN B 471
None
1.00A 2cmlD-5gqrB:
undetectable
2cmlD-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 SER B 495
SER B 497
SER B 473
GLN B 425
None
1.04A 2cmlD-5gqrB:
undetectable
2cmlD-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 PHE B 237
ASN B 183
PHE B 158
ILE B 206
LEU B 213
None
1.18A 2ft9A-5gqrB:
undetectable
2ft9A-5gqrB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 VAL B 565
LEU B 567
ILE B 528
ILE B 532
PHE B 580
None
1.24A 2gj5A-5gqrB:
undetectable
2gj5A-5gqrB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 6 LEU B 470
ASN B 522
ILE B 485
PHE B 461
None
0.94A 2jn3A-5gqrB:
undetectable
2jn3A-5gqrB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 LEU B 572
VAL B 565
ILE B 532
TYR B 508
GLU B 555
None
1.28A 2weyA-5gqrB:
undetectable
2weyA-5gqrB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 TRP B  71
VAL B  75
TRP B  68
None
0.95A 2xdcC-5gqrB:
undetectable
2xdcD-5gqrB:
undetectable
2xdcC-5gqrB:
3.21
2xdcD-5gqrB:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 TRP B  71
VAL B  75
TRP B  68
None
1.00A 2xdcE-5gqrB:
undetectable
2xdcF-5gqrB:
undetectable
2xdcE-5gqrB:
3.21
2xdcF-5gqrB:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 TRP B  71
VAL B  75
TRP B  68
None
0.95A 2y5mE-5gqrB:
undetectable
2y5mF-5gqrB:
undetectable
2y5mE-5gqrB:
3.21
2y5mF-5gqrB:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 TRP B  71
VAL B  75
TRP B  68
None
0.98A 2y6nC-5gqrB:
undetectable
2y6nD-5gqrB:
undetectable
2y6nC-5gqrB:
3.21
2y6nD-5gqrB:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 TRP B  71
VAL B  75
TRP B  68
None
0.97A 2y6nE-5gqrB:
undetectable
2y6nF-5gqrB:
undetectable
2y6nE-5gqrB:
3.21
2y6nF-5gqrB:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 11 ILE B 552
ILE B 586
VAL B 591
ILE B 600
PHE B 580
None
1.15A 3b2rB-5gqrB:
undetectable
3b2rB-5gqrB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 ILE B 289
LEU B 323
PHE B 351
LEU B 352
ILE B 313
None
1.12A 3cd2A-5gqrB:
undetectable
3cd2A-5gqrB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 ILE B 289
SER B 305
PHE B 351
LEU B 352
ILE B 313
None
1.11A 3cd2A-5gqrB:
undetectable
3cd2A-5gqrB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 LEU B 352
LEU B 333
SER B 334
SER B 318
GLY B 316
None
0.99A 3g2oA-5gqrB:
undetectable
3g2oA-5gqrB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 ASN B 139
ASN B 164
GLU B 118
None
0.86A 3kpdC-5gqrB:
undetectable
3kpdC-5gqrB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 ASN B 139
ASN B 164
GLU B 118
None
0.88A 3kpdB-5gqrB:
undetectable
3kpdB-5gqrB:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 10 LEU B 134
ASP B 135
ILE B 125
PHE B 141
SER B 187
None
NAG  B 702 (-4.1A)
None
None
None
1.40A 3m0wE-5gqrB:
undetectable
3m0wF-5gqrB:
undetectable
3m0wG-5gqrB:
undetectable
3m0wH-5gqrB:
undetectable
3m0wE-5gqrB:
9.56
3m0wF-5gqrB:
9.56
3m0wG-5gqrB:
9.56
3m0wH-5gqrB:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 10 LEU B 134
ASP B 135
ILE B 125
SER B 187
PHE B 141
None
NAG  B 702 (-4.1A)
None
None
None
1.44A 3m0wA-5gqrB:
undetectable
3m0wB-5gqrB:
undetectable
3m0wI-5gqrB:
undetectable
3m0wJ-5gqrB:
undetectable
3m0wA-5gqrB:
9.56
3m0wB-5gqrB:
9.56
3m0wI-5gqrB:
9.56
3m0wJ-5gqrB:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 9 ASN B 356
SER B 334
GLY B 335
THR B 382
THR B 358
None
1.46A 3o0qA-5gqrB:
1.1
3o0qA-5gqrB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 ASP B 447
GLU B 518
SER B 377
None
0.86A 3p2kA-5gqrB:
undetectable
3p2kA-5gqrB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
3 / 3 GLN B 228
GLU B 180
LYS B 204
None
1.18A 3su9A-5gqrB:
undetectable
3su9A-5gqrB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 LEU B 117
LEU B 112
ASN B 111
ALA B 160
ILE B 125
None
None
NAG  B 702 (-1.8A)
None
None
1.20A 3ut5D-5gqrB:
undetectable
3ut5D-5gqrB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 LEU B 567
PHE B 612
THR B 587
ASP B 564
None
1.04A 4drjB-5gqrB:
undetectable
4drjB-5gqrB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 SER B 124
ILE B  97
LEU B 134
ILE B 136
None
0.93A 4dtaB-5gqrB:
undetectable
4dtaB-5gqrB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 ALA B 464
LEU B 440
PHE B 461
LEU B 448
THR B 463
None
1.16A 4eckB-5gqrB:
undetectable
4eckB-5gqrB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 7 PHE B 121
PHE B 141
LEU B  46
LEU B 117
None
0.90A 4ejgC-5gqrB:
undetectable
4ejgC-5gqrB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 PHE B 514
ALA B 464
ALA B 488
ALA B 462
LEU B 472
None
1.07A 4j6dA-5gqrB:
undetectable
4j6dA-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 PHE B 514
ALA B 464
ALA B 488
ALA B 462
LEU B 472
None
1.07A 4j6dB-5gqrB:
undetectable
4j6dB-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 PHE B 514
ALA B 464
ALA B 488
ALA B 462
LEU B 472
None
1.07A 4jbtA-5gqrB:
undetectable
4jbtA-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 ARG B 177
LEU B 176
ASP B 172
ILE B 149
None
1.02A 4k0bA-5gqrB:
undetectable
4k0bA-5gqrB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 SER B 327
PHE B 351
LEU B 302
GLU B 231
ASP B 255
None
1.31A 4qb9E-5gqrB:
undetectable
4qb9E-5gqrB:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 9 PHE B 254
LEU B 269
TYR B 293
LEU B 280
PHE B 304
None
1.40A 4qopA-5gqrB:
undetectable
4qopA-5gqrB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 9 PHE B 254
LEU B 269
TYR B 293
LEU B 280
PHE B 304
None
1.40A 4qopB-5gqrB:
undetectable
4qopB-5gqrB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 8 PHE B 245
ARG B 220
ALA B 195
GLY B 222
None
0.81A 4xk8a-5gqrB:
undetectable
4xk8a-5gqrB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 5 ALA B 496
HIS B 534
PRO B 506
PHE B 514
None
1.28A 4ze2A-5gqrB:
undetectable
4ze2A-5gqrB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 5 LYS B 321
GLU B 343
GLY B 342
SER B 318
None
1.04A 5jhdJ-5gqrB:
undetectable
5jhdJ-5gqrB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 LEU B  42
LEU B  39
LEU B 107
ILE B  97
LEU B 128
None
0.91A 5toaA-5gqrB:
undetectable
5toaA-5gqrB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 SER B 187
THR B 123
LEU B 169
PHE B 158
LEU B 182
None
1.31A 6a93A-5gqrB:
undetectable
6a93A-5gqrB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 12 SER B 187
THR B 123
LEU B 169
PHE B 158
LEU B 182
None
1.37A 6a93B-5gqrB:
undetectable
6a93B-5gqrB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 5 ASP B 447
ILE B 457
PHE B 477
ASN B 403
None
1.22A 6a93B-5gqrB:
undetectable
6a93B-5gqrB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
6 / 10 SER B 388
LEU B 350
LEU B 395
ILE B 341
PRO B 362
GLY B 342
None
1.25A 6dm0B-5gqrB:
undetectable
6dm0C-5gqrB:
undetectable
6dm0B-5gqrB:
8.32
6dm0C-5gqrB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 9 PRO B 362
GLY B 342
SER B 388
LEU B 350
LEU B 395
None
1.22A 6dm0A-5gqrB:
undetectable
6dm0D-5gqrB:
undetectable
6dm0A-5gqrB:
8.32
6dm0D-5gqrB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 10 SER B 388
LEU B 350
LEU B 395
ILE B 341
PRO B 362
None
1.30A 6dm2B-5gqrB:
undetectable
6dm2C-5gqrB:
undetectable
6dm2B-5gqrB:
8.32
6dm2C-5gqrB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
5 / 10 ILE B 341
PRO B 362
SER B 388
LEU B 350
LEU B 395
None
1.30A 6dm2A-5gqrB:
undetectable
6dm2D-5gqrB:
undetectable
6dm2A-5gqrB:
8.32
6dm2D-5gqrB:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 6 GLY B 222
LEU B 247
VAL B 256
PHE B 285
None
1.02A 6h7lA-5gqrB:
undetectable
6h7lA-5gqrB:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 6 GLY B 222
LEU B 247
VAL B 256
PHE B 285
None
1.02A 6h7lB-5gqrB:
undetectable
6h7lB-5gqrB:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana)
4 / 5 LEU B 227
GLN B 228
PHE B 205
PHE B 245
None
1.33A 6nmpP-5gqrB:
undetectable
6nmpW-5gqrB:
undetectable
6nmpP-5gqrB:
16.36
6nmpW-5gqrB:
7.80