SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		3 / 3 VAL A  39
VAL A 133
TRP A  16
 None
 0.84A 1av2C-5gqtA:
undetectable
1av2D-5gqtA:
undetectable		 1av2C-5gqtA:
2.86
1av2D-5gqtA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 7 LEU A 217
VAL A 262
TYR A 243
GLY A 245
 None
 0.93A 1lweA-5gqtA:
undetectable		 1lweA-5gqtA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		3 / 3 VAL A  39
VAL A 133
TRP A  16
 None
 0.81A 1w5uC-5gqtA:
undetectable
1w5uD-5gqtA:
undetectable		 1w5uC-5gqtA:
2.86
1w5uD-5gqtA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 7 GLY A 320
SER A 369
PHE A 337
ARG A 292
 None
 0.97A 2c8aB-5gqtA:
undetectable		 2c8aB-5gqtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		3 / 3 VAL A 133
TRP A  16
VAL A  39
 None
 0.76A 2izqA-5gqtA:
undetectable
2izqB-5gqtA:
undetectable		 2izqA-5gqtA:
2.86
2izqB-5gqtA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 7 ARG A 292
GLU A 341
GLU A 386
SER A 369
 None
 1.04A 2zt7A-5gqtA:
undetectable		 2zt7A-5gqtA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 382
ILE A 380
VAL A 327
LYS A 330
ARG A 319
 None
 1.13A 3em0B-5gqtA:
2.1		 3em0B-5gqtA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		3 / 3 VAL A  39
VAL A 133
TRP A  16
 None
 0.81A 3l8lC-5gqtA:
undetectable
3l8lD-5gqtA:
undetectable		 3l8lC-5gqtA:
2.86
3l8lD-5gqtA:
2.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		3 / 3 TYR A 335
ARG A 319
HIS A 346
 None
 1.01A 4fubA-5gqtA:
undetectable		 4fubA-5gqtA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 6 ARG A 292
GLU A 341
GLU A 386
SER A 369
 None
 1.04A 4kr3A-5gqtA:
undetectable		 4kr3A-5gqtA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 6 THR A  59
GLN A  31
THR A 131
HIS A 135
 None
 1.37A 4pfjB-5gqtA:
undetectable		 4pfjB-5gqtA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 9 VAL A  39
VAL A  29
TYR A  43
ILE A  97
LEU A 137
 None
 1.36A 5e4dA-5gqtA:
undetectable		 5e4dA-5gqtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 171
ALA A 172
GLY A 183
LEU A 231
GLY A 450
 None
 1.15A 5i71A-5gqtA:
undetectable		 5i71A-5gqtA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 12 GLU A  82
VAL A 114
GLU A  11
THR A 131
GLY A  13
 None
 1.42A 5xioA-5gqtA:
undetectable		 5xioA-5gqtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 9 VAL A 363
GLY A 362
LEU A 149
ARG A 416
ASP A 418
 None
 1.46A 6c2mC-5gqtA:
undetectable		 6c2mC-5gqtA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 9 VAL A 363
GLY A 362
LYS A 148
ARG A 416
ASP A 418
 None
 1.37A 6c2mC-5gqtA:
undetectable		 6c2mC-5gqtA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 10 GLY A 323
GLY A 336
VAL A 345
ASP A 344
ILE A 380
 None
 1.14A 6exiA-5gqtA:
undetectable		 6exiA-5gqtA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 10 GLY A 323
GLY A 336
VAL A 345
ASP A 344
ILE A 380
 None
 1.14A 6exiB-5gqtA:
undetectable		 6exiB-5gqtA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 323
GLY A 336
VAL A 345
ASP A 344
ILE A 380
 None
 1.13A 6exiC-5gqtA:
undetectable
6exiD-5gqtA:
undetectable		 6exiC-5gqtA:
10.13
6exiD-5gqtA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 6 ASP A 343
TYR A  76
GLU A  78
GLU A 109
 None
 1.46A 6mn5A-5gqtA:
undetectable		 6mn5A-5gqtA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5gqt NITRILE-SPECIFIER
PROTEIN 1
(Arabidopsis
thaliana) 		4 / 6 ASP A 343
TYR A  76
GLU A  78
GLU A 109
 None
 1.46A 6mn5C-5gqtA:
undetectable		 6mn5C-5gqtA:
10.17