SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 5 LEU A 231
LEU A 226
SER A 218
LEU A 221
None
0.76A 1a4lC-5gr8A:
undetectable
1a4lC-5gr8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 7 LEU A 167
SER A 190
SER A 166
THR A 142
None
0.99A 1dvxA-5gr8A:
undetectable
1dvxA-5gr8A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 8 LEU A 224
LEU A 197
LEU A 167
SER A 190
None
1.17A 1hk2A-5gr8A:
undetectable
1hk2A-5gr8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 8 SER A 422
ASN A 445
GLU A 378
GLY A 377
None
0.93A 1meiA-5gr8A:
undetectable
1meiA-5gr8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 SER A 112
LEU A  39
LEU A 104
LEU A 119
PRO A 116
None
1.48A 1p33A-5gr8A:
undetectable
1p33A-5gr8A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ILE A 427
SER A 478
ILE A 479
LEU A 464
ILE A 451
None
1.00A 1rb3B-5gr8A:
undetectable
1rb3B-5gr8A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 8 SER A 214
LEU A 163
LEU A 176
LEU A 173
None
0.92A 2bfpD-5gr8A:
undetectable
2bfpD-5gr8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 11 LEU A 272
LEU A 248
SER A 234
LEU A 235
LEU A 274
None
1.11A 2ceoA-5gr8A:
undetectable
2ceoA-5gr8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 GLY A 251
ASN A 321
GLY A 282
LEU A 303
LEU A 327
NAG  A 803 ( 3.9A)
None
SO4  A 807 (-3.9A)
None
None
1.08A 2hw2A-5gr8A:
undetectable
2hw2A-5gr8A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 8 LEU A 176
SER A 201
LEU A 178
ASP A 179
None
1.03A 2j2pA-5gr8A:
undetectable
2j2pB-5gr8A:
undetectable
2j2pA-5gr8A:
14.41
2j2pB-5gr8A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ILE A 331
SER A 330
ILE A 307
LEU A 335
ASN A 337
None
1.06A 2nnhA-5gr8A:
undetectable
2nnhA-5gr8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ILE A 383
ALA A 333
GLY A 336
GLY A 360
PRO A 332
None
1.11A 2okcA-5gr8A:
undetectable
2okcA-5gr8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ILE A 383
ALA A 333
GLY A 336
GLY A 360
PRO A 332
None
1.12A 2okcB-5gr8A:
undetectable
2okcB-5gr8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 8 LEU A 272
PRO A 308
SER A 310
GLY A 282
None
None
NAG  A 805 ( 4.8A)
SO4  A 807 (-3.9A)
1.08A 2qd5B-5gr8A:
undetectable
2qd5B-5gr8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
3 / 3 SER A 328
ARG A 374
GLN A 350
None
0.90A 2xnrA-5gr8A:
undetectable
2xnrA-5gr8A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 7 ILE A 479
GLY A 480
PHE A 502
PHE A 513
None
0.83A 2y7wC-5gr8A:
undetectable
2y7wC-5gr8A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ILE A 115
LEU A 149
SER A 131
LEU A 178
ILE A 139
None
1.11A 3cd2A-5gr8A:
undetectable
3cd2A-5gr8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ILE A 307
LEU A 341
SER A 323
LEU A 370
ILE A 331
None
1.17A 3cd2A-5gr8A:
undetectable
3cd2A-5gr8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ILE A 307
LEU A 362
LYS A 345
LEU A 370
ILE A 331
None
1.14A 3cd2A-5gr8A:
undetectable
3cd2A-5gr8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 LEU A 550
GLY A 527
SER A 503
LEU A 553
LEU A 556
None
1.44A 3cjtK-5gr8A:
undetectable
3cjtK-5gr8A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 7 LEU A 272
PRO A 308
SER A 310
GLY A 282
None
None
NAG  A 805 ( 4.8A)
SO4  A 807 (-3.9A)
1.07A 3hcnA-5gr8A:
undetectable
3hcnA-5gr8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 8 LEU A 272
PRO A 308
SER A 310
GLY A 282
None
None
NAG  A 805 ( 4.8A)
SO4  A 807 (-3.9A)
1.08A 3hcrA-5gr8A:
undetectable
3hcrA-5gr8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 7 LEU A 272
PRO A 308
SER A 310
GLY A 282
None
None
NAG  A 805 ( 4.8A)
SO4  A 807 (-3.9A)
1.08A 3hcrB-5gr8A:
undetectable
3hcrB-5gr8A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 10 LEU A 658
ILE A 618
PRO A 619
SER A 615
GLY A 617
None
1.43A 3iluB-5gr8A:
undetectable
3iluE-5gr8A:
undetectable
3iluB-5gr8A:
14.59
3iluE-5gr8A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 7 LEU A 119
LEU A 104
SER A 131
THR A  83
None
None
None
NAG  A 806 ( 4.6A)
0.90A 3lm8A-5gr8A:
undetectable
3lm8C-5gr8A:
undetectable
3lm8A-5gr8A:
15.89
3lm8C-5gr8A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 PHE A 168
LEU A 197
ILE A 215
PRO A 212
SER A 214
None
1.01A 3nrrA-5gr8A:
undetectable
3nrrA-5gr8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 PHE A 168
LEU A 197
ILE A 215
PRO A 212
SER A 214
None
1.01A 3nrrB-5gr8A:
undetectable
3nrrB-5gr8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 7 PRO A 236
VAL A 250
LEU A 248
ILE A 215
None
1.00A 3u5kB-5gr8A:
undetectable
3u5kB-5gr8A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 5 LEU A 466
GLY A 467
PHE A 488
ASN A 516
None
0.99A 3uq6B-5gr8A:
undetectable
3uq6B-5gr8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 ALA A 634
LEU A 631
ILE A 642
PRO A 643
LEU A 671
None
1.17A 4gh8A-5gr8A:
undetectable
4gh8A-5gr8A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 4 LEU A 735
SER A 730
LEU A 722
LEU A 691
None
1.07A 4n09A-5gr8A:
undetectable
4n09A-5gr8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 5 ILE A 642
LEU A 663
ASP A 657
VAL A 594
None
0.98A 4nkxB-5gr8A:
undetectable
4nkxB-5gr8A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
None
1.04A 4o2bB-5gr8A:
undetectable
4o2bB-5gr8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 LEU A 239
LEU A 221
LEU A 226
ILE A 191
ILE A 187
None
1.11A 4o2bB-5gr8A:
undetectable
4o2bB-5gr8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 9 ILE A 535
PHE A 502
LEU A 511
LEU A 499
PHE A 518
None
1.41A 4qopA-5gr8A:
undetectable
4qopA-5gr8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 9 ILE A 535
PHE A 502
LEU A 511
LEU A 499
PHE A 518
None
1.41A 4qopB-5gr8A:
undetectable
4qopB-5gr8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
None
1.15A 4x1iD-5gr8A:
undetectable
4x1iD-5gr8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
None
1.09A 4x1yB-5gr8A:
undetectable
4x1yB-5gr8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 PHE A 168
ILE A 115
LEU A 178
LEU A 176
LEU A 152
None
1.14A 4xumA-5gr8A:
undetectable
4xumA-5gr8A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
None
0.98A 5itzB-5gr8A:
undetectable
5itzB-5gr8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
4 / 4 ASN A 732
LEU A 735
SER A 730
LEU A 722
None
1.09A 5kb5A-5gr8A:
undetectable
5kb5A-5gr8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
None
1.04A 5mioB-5gr8A:
undetectable
5mioB-5gr8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 LEU A 359
LEU A 344
SER A 323
LEU A 322
LEU A 351
None
1.22A 5mwyA-5gr8A:
undetectable
5mwyA-5gr8A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 10 LEU A 231
ILE A 215
ASN A 277
LEU A 224
LEU A 274
None
1.21A 5y7pG-5gr8A:
undetectable
5y7pG-5gr8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 12 PHE A 710
LEU A 735
ASN A 732
PHE A 729
ILE A 642
None
1.35A 6dwnB-5gr8A:
undetectable
6dwnB-5gr8A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 10 PHE A 168
LEU A 173
SER A 218
GLY A 192
ILE A 191
None
0.93A 6ebpB-5gr8A:
undetectable
6ebpB-5gr8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 10 PHE A 168
LEU A 173
SER A 218
GLY A 192
ILE A 191
None
0.96A 6ebpC-5gr8A:
undetectable
6ebpC-5gr8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 11 PHE A 168
LEU A 173
SER A 218
GLY A 192
ILE A 191
None
0.96A 6ebzA-5gr8A:
undetectable
6ebzA-5gr8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 11 PHE A 168
LEU A 173
SER A 218
GLY A 192
ILE A 191
None
0.95A 6ebzB-5gr8A:
undetectable
6ebzB-5gr8A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana)
5 / 11 PHE A 168
LEU A 173
SER A 218
GLY A 192
ILE A 191
None
0.98A 6gp2A-5gr8A:
undetectable
6gp2A-5gr8A:
8.37