SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5grh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.21A 1fohA-5grhB:
undetectable		 1fohA-5grhB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.22A 1fohB-5grhB:
undetectable		 1fohB-5grhB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.26A 1fohC-5grhB:
undetectable		 1fohC-5grhB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.30A 1fohD-5grhB:
undetectable		 1fohD-5grhB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.23A 1pn0A-5grhB:
undetectable		 1pn0A-5grhB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.22A 1pn0B-5grhB:
undetectable		 1pn0B-5grhB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.30A 1pn0C-5grhB:
undetectable		 1pn0C-5grhB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP B 326
GLY B 253
MET B 317
ILE B 327
GLY B 251
 None
 1.30A 1pn0D-5grhB:
undetectable		 1pn0D-5grhB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL B  34
PHE B  47
VAL B  45
VAL B  37
LEU B 297
 None
 1.04A 1z9yA-5grhB:
undetectable		 1z9yA-5grhB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY B 253
HIS B 323
THR B 324
ALA B 246
ALA B 288
 None
 0.94A 2gluB-5grhB:
undetectable		 2gluB-5grhB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA B 265
SER B 293
ALA B 288
GLY B 257
VAL B 106
 None
 1.17A 2zifB-5grhB:
undetectable		 2zifB-5grhB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 THR B 287
ALA B 288
LEU B 290
ALA B 292
SER B 293
 None
 1.36A 3kp6B-5grhB:
undetectable		 3kp6B-5grhB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN B 130
ASN B 239
GLU B 134
 None
 0.93A 3kpdC-5grhB:
undetectable		 3kpdC-5grhB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASN B 235
GLY B 133
GLU B 134
LYS B 151
 None
 1.39A 3r2cA-5grhB:
0.0		 3r2cA-5grhB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 HIS B  51
GLY B  27
GLY B  23
ALA B 284
ASN B 280
 None
 1.22A 3vywB-5grhB:
2.4		 3vywB-5grhB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA B 256
GLY B 257
ASN B 285
GLY B 253
ARG B 310
 None
 1.25A 4obwD-5grhB:
undetectable		 4obwD-5grhB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR B 274
GLY B  27
ILE B 278
SER B 277
LEU B  30
 None
 1.32A 4pooA-5grhB:
undetectable		 4pooA-5grhB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 VAL B  50
LEU B  96
ILE B  68
ALA B  67
 None
 0.75A 4zf8A-5grhB:
undetectable		 4zf8A-5grhB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLY B 257
TYR B 164
TYR B 260
GLY B 261
 None
 1.02A 5ayfA-5grhB:
undetectable		 5ayfA-5grhB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU B 236
GLU B 129
ARG B 160
ILE B 153
ILE B 152
 None
 1.28A 5ifuA-5grhB:
3.1		 5ifuA-5grhB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 5grh ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT GAMMA,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN B  94
ASN B  93
ASN B 239
GLY B 133
ILE B 161
 None
 1.33A 6dwnA-5grhB:
undetectable		 6dwnA-5grhB:
12.25