SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5grj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR H  95
TYR L  38
PRO L  46
TYR L  89
 None
 0.67A 2oldA-5grjH:
13.5
2oldB-5grjH:
13.6		 2oldA-5grjH:
27.65
2oldB-5grjH:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR L  38
PRO L  46
TYR L  89
TYR H  95
 None
 0.61A 2oldA-5grjL:
21.7
2oldB-5grjL:
21.6		 2oldA-5grjL:
84.68
2oldB-5grjL:
84.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ALA H  92
ALA L  45
PRO L  46
GLY H 113
LEU H 115
 None
 1.19A 2zifB-5grjH:
undetectable		 2zifB-5grjH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE L  50
GLN L   6
TYR L  88
GLN H  39
LEU H  45
 None
 1.14A 4qztA-5grjL:
undetectable		 4qztA-5grjL:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5grj AVELUMAB L CHAIN
(Homo
sapiens) 		4 / 7 LEU L   4
SER L  92
GLY L  30
GLY L  31
 None
 0.73A 4yjiA-5grjL:
undetectable		 4yjiA-5grjL:
10.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5grj AVELUMAB L CHAIN
(Homo
sapiens) 		4 / 7 SER L  36
TYR L  38
TYR L  51
PRO L  57
 None
 0.75A 5aclA-5grjL:
21.9		 5aclA-5grjL:
83.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5grj AVELUMAB L CHAIN
(Homo
sapiens) 		4 / 8 SER L  36
TYR L  38
SER L  97
PHE L 101
 None
 0.69A 5alcL-5grjL:
20.5		 5alcL-5grjL:
65.77