SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5grm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		5 / 10 LEU A 259
LEU A 330
GLY A 255
ALA A 256
LEU A 190
 None
 1.12A 1pxxA-5grmA:
undetectable		 1pxxA-5grmA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A 259
LEU A 330
GLY A 255
ALA A 256
LEU A 190
 None
 0.96A 3n8zB-5grmA:
undetectable		 3n8zB-5grmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A 259
LEU A 330
GLY A 255
ALA A 256
LEU A 190
 None
 1.03A 4otyA-5grmA:
undetectable		 4otyA-5grmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A 259
LEU A 330
GLY A 255
ALA A 256
LEU A 190
 None
 0.99A 4otyB-5grmA:
undetectable		 4otyB-5grmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A 190
LEU A 225
HIS A 308
LEU A 198
ILE A 258
 None
 0.99A 4x1fA-5grmA:
undetectable		 4x1fA-5grmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A 190
LEU A 225
HIS A 308
LEU A 198
ILE A 258
 None
 0.96A 4x1gA-5grmA:
undetectable		 4x1gA-5grmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		3 / 3 ARG A 310
HIS A 308
ARG A 197
 None
 1.12A 5iaoC-5grmA:
undetectable		 5iaoC-5grmA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		3 / 3 ARG A 310
HIS A 308
ARG A 197
 None
 1.13A 5iaoF-5grmA:
undetectable		 5iaoF-5grmA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A 259
LEU A 330
GLY A 255
ALA A 256
LEU A 190
 None
 1.08A 5ikqB-5grmA:
undetectable		 5ikqB-5grmA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5grm STIMULATOR OF
INTERFERON GENES
PROTEIN
(Rattus
norvegicus) 		4 / 6 TYR A 240
LEU A 172
GLU A 260
LEU A 198
 None
 1.42A 5xooA-5grmA:
undetectable		 5xooA-5grmA:
19.23