SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5grn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
VAL A 658
ASN A 823
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
None
748  A1001 (-4.3A)
 0.63A 1fmoE-5grnA:
14.3		 1fmoE-5grnA:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.76A 1iepA-5grnA:
29.9		 1iepA-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.78A 1iepB-5grnA:
29.6		 1iepB-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.63A 1m17A-5grnA:
24.3		 1m17A-5grnA:
31.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
GLY A 600
VAL A 607
ALA A 625
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.70A 1muoA-5grnA:
18.0		 1muoA-5grnA:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.58A 1opjA-5grnA:
28.3		 1opjA-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
GLY A 680
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.64A 1opjB-5grnA:
28.1		 1opjB-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 LEU A 599
LYS A 627
ILE A 672
ARG A 817
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
 0.69A 1opjB-5grnA:
28.1		 1opjB-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		11 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
VAL A 658
THR A 674
GLY A 680
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.39A 1t46A-5grnA:
32.9		 1t46A-5grnA:
61.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 TYR A 676
CYH A 677
ARG A 817
CYH A 835
 748  A1001 (-4.0A)
748  A1001 (-4.5A)
None
748  A1001 (-4.5A)
 0.28A 1t46A-5grnA:
32.9		 1t46A-5grnA:
61.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 TYR A 676
CYH A 677
CYH A 814
ARG A 817
 748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 (-3.4A)
None
 0.88A 1t46A-5grnA:
32.9		 1t46A-5grnA:
61.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.51A 1uwhA-5grnA:
18.6		 1uwhA-5grnA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.52A 1uwhB-5grnA:
18.5		 1uwhB-5grnA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 VAL A 607
ALA A 625
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.59A 1uwjA-5grnA:
7.8		 1uwjA-5grnA:
28.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 VAL A 607
ALA A 625
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.58A 1uwjB-5grnA:
7.8		 1uwjB-5grnA:
28.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 LEU A 599
VAL A 607
ALA A 625
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.58A 1xbbA-5grnA:
31.4		 1xbbA-5grnA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 VAL A 607
LYS A 627
VAL A 658
ASP A 681
ASN A 823
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
None
None
748  A1001 (-4.3A)
 0.60A 2eufB-5grnA:
11.1		 2eufB-5grnA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
TYR A 676
ASN A 823
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
None
 0.53A 2fumC-5grnA:
17.7		 2fumC-5grnA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.94A 2gqgA-5grnA:
25.8		 2gqgA-5grnA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.97A 2gqgA-5grnA:
25.8		 2gqgA-5grnA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.65A 2gqgB-5grnA:
31.8		 2gqgB-5grnA:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.72A 2hyyA-5grnA:
29.9		 2hyyA-5grnA:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.65A 2hyyB-5grnA:
29.7		 2hyyB-5grnA:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
VAL A 658
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.61A 2hyyC-5grnA:
29.6		 2hyyC-5grnA:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 LEU A 599
LYS A 627
MET A 648
ILE A 672
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
 0.81A 2hyyC-5grnA:
29.6		 2hyyC-5grnA:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
ILE A 672
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.66A 2hyyD-5grnA:
29.7		 2hyyD-5grnA:
36.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
 0.75A 2itoA-5grnA:
24.9		 2itoA-5grnA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.70A 2itoA-5grnA:
24.9		 2itoA-5grnA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
 0.77A 2ityA-5grnA:
24.6		 2ityA-5grnA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.85A 2ityA-5grnA:
24.6		 2ityA-5grnA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
 0.72A 2itzA-5grnA:
24.5		 2itzA-5grnA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.79A 2itzA-5grnA:
24.5		 2itzA-5grnA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
GLY A 600
VAL A 607
LYS A 627
GLU A 644
TYR A 676
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.0A)
 0.55A 2ivuA-5grnA:
26.4		 2ivuA-5grnA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
GLY A 600
VAL A 607
LYS A 627
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.47A 2ivuA-5grnA:
26.4		 2ivuA-5grnA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.72A 2oiqA-5grnA:
26.3		 2oiqA-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
GLY A 680
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.86A 2oiqA-5grnA:
26.3		 2oiqA-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
TYR A 676
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.74A 2pl0A-5grnA:
25.9		 2pl0A-5grnA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.81A 2pl0A-5grnA:
25.9		 2pl0A-5grnA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.62A 2y6oA-5grnA:
27.0		 2y6oA-5grnA:
30.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.89A 2zvaA-5grnA:
25.8		 2zvaA-5grnA:
37.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 10 LEU A 599
ALA A 625
LYS A 627
VAL A 658
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.93A 3aoxA-5grnA:
25.0		 3aoxA-5grnA:
35.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 VAL A 607
ALA A 625
LEU A 660
THR A 674
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
None
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.64A 3bbtB-5grnA:
23.6		 3bbtB-5grnA:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
GLY A 600
GLU A 609
ALA A 625
LYS A 627
VAL A 658
CYH A 677
GLY A 680
LEU A 825
CYH A 835
 748  A1001 (-3.8A)
None
None
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
 0.68A 3c7qA-5grnA:
28.2		 3c7qA-5grnA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 10 LEU A 599
VAL A 607
LYS A 627
ILE A 672
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-4.8A)
 0.89A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 10 LEU A 599
VAL A 607
VAL A 658
ILE A 672
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.8A)
 0.74A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
HIS A 816
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
 0.51A 3cs9A-5grnA:
29.6		 3cs9A-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.61A 3cs9B-5grnA:
27.5		 3cs9B-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 LEU A 599
VAL A 607
VAL A 658
ILE A 672
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.3A)
 0.45A 3cs9B-5grnA:
27.5		 3cs9B-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
MET A 648
THR A 674
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.60A 3cs9C-5grnA:
27.2		 3cs9C-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 LEU A 599
VAL A 607
LYS A 627
ILE A 672
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.7A)
 1.22A 3cs9C-5grnA:
27.2		 3cs9C-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 VAL A 607
LYS A 627
ILE A 672
VAL A 824
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
748  A1001 (-3.7A)
 1.23A 3cs9C-5grnA:
27.2		 3cs9C-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
 0.61A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 LEU A 599
VAL A 607
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.77A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 LEU A 599
VAL A 607
LYS A 627
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.81A 3cs9D-5grnA:
29.4		 3cs9D-5grnA:
36.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ILE A 834
ASP A 877
ALA A 810
ILE A 647
LEU A 651
 748  A1001 (-4.8A)
None
None
748  A1001 ( 4.0A)
None
 1.06A 3dauA-5grnA:
undetectable		 3dauA-5grnA:
19.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.42A 3fupB-5grnA:
23.4		 3fupB-5grnA:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 11 LEU A 599
VAL A 607
ALA A 625
VAL A 658
THR A 674
TYR A 676
ALA A 840
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
None
 0.84A 3g0eA-5grnA:
29.1		 3g0eA-5grnA:
60.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 11 LEU A 599
VAL A 607
ALA A 625
VAL A 658
THR A 674
TYR A 676
CYH A 677
GLY A 680
LEU A 825
CYH A 835
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
 0.68A 3g0eA-5grnA:
29.1		 3g0eA-5grnA:
60.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		11 / 11 LEU A 599
VAL A 607
ALA A 625
THR A 674
TYR A 676
CYH A 677
GLY A 680
ASP A 681
LEU A 825
CYH A 835
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
None
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
 0.68A 3g0fA-5grnA:
31.4		 3g0fA-5grnA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 10 LEU A 599
VAL A 607
ALA A 625
THR A 674
TYR A 676
CYH A 677
GLY A 680
LEU A 825
CYH A 835
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
 0.61A 3g0fB-5grnA:
30.8		 3g0fB-5grnA:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		11 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.68A 3g5dA-5grnA:
25.3		 3g5dA-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		11 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.78A 3g5dB-5grnA:
25.3		 3g5dB-5grnA:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 VAL A 607
ALA A 625
GLU A 644
THR A 674
HIS A 816
ASP A 836
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.83A 3gp0A-5grnA:
11.2		 3gp0A-5grnA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.64A 3gvuA-5grnA:
28.5		 3gvuA-5grnA:
35.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 LEU A 839
GLN A 639
LEU A 641
GLU A 637
 None
 1.04A 3h5gB-5grnA:
undetectable
3h5gC-5grnA:
undetectable		 3h5gB-5grnA:
6.18
3h5gC-5grnA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
LYS A 627
GLU A 644
THR A 674
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.66A 3hecA-5grnA:
17.5		 3hecA-5grnA:
27.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
MET A 648
VAL A 658
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.66A 3ik3A-5grnA:
28.5		 3ik3A-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 LEU A 599
LYS A 627
ILE A 672
ARG A 817
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
 1.03A 3ik3A-5grnA:
28.5		 3ik3A-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
MET A 648
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.51A 3ik3B-5grnA:
34.6		 3ik3B-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 GLU A 644
MET A 648
VAL A 658
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.70A 3ik3B-5grnA:
34.6		 3ik3B-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 LEU A 599
LYS A 627
ILE A 672
ARG A 817
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
 1.05A 3ik3B-5grnA:
34.6		 3ik3B-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.83A 3k54A-5grnA:
30.4		 3k54A-5grnA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
VAL A 658
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.84A 3k54A-5grnA:
30.4		 3k54A-5grnA:
35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.61A 3k5vA-5grnA:
34.3		 3k5vA-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.62A 3k5vB-5grnA:
28.5		 3k5vB-5grnA:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 ALA A 625
LYS A 627
GLU A 644
THR A 674
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
 0.33A 3lfaA-5grnA:
19.9		 3lfaA-5grnA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
VAL A 658
TYR A 676
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
 0.49A 3lxkA-5grnA:
23.2		 3lxkA-5grnA:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.56A 3lxkA-5grnA:
23.2		 3lxkA-5grnA:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.41A 3lxnA-5grnA:
21.2		 3lxnA-5grnA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.71A 3ms9A-5grnA:
29.7		 3ms9A-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.70A 3ms9B-5grnA:
29.7		 3ms9B-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.74A 3mssA-5grnA:
29.6		 3mssA-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.72A 3mssB-5grnA:
29.6		 3mssB-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.63A 3mssB-5grnA:
29.6		 3mssB-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.74A 3mssC-5grnA:
29.6		 3mssC-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.70A 3mssD-5grnA:
29.6		 3mssD-5grnA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.65A 3octA-5grnA:
13.0		 3octA-5grnA:
33.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.58A 3oezA-5grnA:
25.9		 3oezA-5grnA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
TYR A 676
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.76A 3oezA-5grnA:
25.9		 3oezA-5grnA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.91A 3oezB-5grnA:
25.8		 3oezB-5grnA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.38A 3og7A-5grnA:
26.9		 3og7A-5grnA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 GLY A 600
VAL A 607
ALA A 625
LYS A 627
THR A 674
LEU A 825
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
 1.02A 3ohtA-5grnA:
16.4		 3ohtA-5grnA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 GLY A 600
VAL A 607
ALA A 625
LYS A 627
THR A 674
GLY A 680
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
 0.76A 3ohtB-5grnA:
5.4		 3ohtB-5grnA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 GLY A 600
VAL A 607
ALA A 625
THR A 674
GLY A 680
ASN A 684
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
None
 0.81A 3ohtB-5grnA:
5.4		 3ohtB-5grnA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
GLY A 680
HIS A 816
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.89A 3oxzA-5grnA:
27.6		 3oxzA-5grnA:
34.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
GLY A 680
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.60A 3oxzA-5grnA:
27.6		 3oxzA-5grnA:
34.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 LEU A 599
LYS A 627
ILE A 672
ARG A 817
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
None
748  A1001 (-4.3A)
 0.83A 3oxzA-5grnA:
27.6		 3oxzA-5grnA:
34.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.59A 3pyyA-5grnA:
29.6		 3pyyA-5grnA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
 0.81A 3pyyA-5grnA:
29.6		 3pyyA-5grnA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
THR A 674
GLY A 680
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.71A 3pyyA-5grnA:
29.6		 3pyyA-5grnA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.65A 3pyyB-5grnA:
27.3		 3pyyB-5grnA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.84A 3qlgA-5grnA:
25.4		 3qlgA-5grnA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.85A 3qlgA-5grnA:
25.4		 3qlgA-5grnA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.80A 3qlgB-5grnA:
25.1		 3qlgB-5grnA:
34.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.65A 3sxrA-5grnA:
30.1		 3sxrA-5grnA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
VAL A 658
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.56A 3sxrA-5grnA:
30.1		 3sxrA-5grnA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.63A 3sxrB-5grnA:
25.0		 3sxrB-5grnA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.73A 3ue4A-5grnA:
25.7		 3ue4A-5grnA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
ALA A 625
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.78A 3ue4A-5grnA:
25.7		 3ue4A-5grnA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.75A 3ue4B-5grnA:
26.4		 3ue4B-5grnA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.73A 3ue4B-5grnA:
26.4		 3ue4B-5grnA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
CYH A 677
GLY A 680
CYH A 835
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.5A)
 0.57A 3wzdA-5grnA:
27.7		 3wzdA-5grnA:
49.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
GLY A 680
LEU A 809
HIS A 816
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.45A 3wzeA-5grnA:
33.2		 3wzeA-5grnA:
49.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 8 VAL A 658
CYH A 677
LEU A 825
ILE A 834
CYH A 835
ASP A 836
PHE A 837
 748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-4.5A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.39A 3wzeA-5grnA:
33.2		 3wzeA-5grnA:
49.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
LEU A 809
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.55A 3zosA-5grnA:
28.0		 3zosA-5grnA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
LYS A 627
GLU A 644
LEU A 809
HIS A 816
ARG A 817
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.73A 3zosA-5grnA:
28.0		 3zosA-5grnA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 ILE A 647
MET A 648
ILE A 657
TYR A 676
ILE A 834
 748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.85A 3zosA-5grnA:
28.0		 3zosA-5grnA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 ALA A 625
LYS A 627
GLU A 644
THR A 674
LEU A 809
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.58A 3zosB-5grnA:
28.1		 3zosB-5grnA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
ILE A 647
MET A 648
ILE A 657
TYR A 676
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.84A 3zosB-5grnA:
28.1		 3zosB-5grnA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
VAL A 658
GLY A 680
LEU A 825
CYH A 835
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
 0.43A 4ag8A-5grnA:
42.8		 4ag8A-5grnA:
48.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
GLY A 680
LEU A 825
CYH A 835
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
 0.45A 4agcA-5grnA:
32.3		 4agcA-5grnA:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 11 LEU A 599
ALA A 625
VAL A 658
CYH A 677
GLY A 680
LEU A 825
CYH A 835
PHE A 837
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
 0.46A 4agdA-5grnA:
41.0		 4agdA-5grnA:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 11 LEU A 599
LYS A 627
VAL A 658
GLY A 680
LEU A 825
CYH A 835
PHE A 837
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
 0.63A 4agdA-5grnA:
41.0		 4agdA-5grnA:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
GLY A 680
LEU A 809
HIS A 816
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-3.7A)
 0.51A 4asdA-5grnA:
42.2		 4asdA-5grnA:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 6 VAL A 658
CYH A 677
LEU A 825
ILE A 834
CYH A 835
 748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-4.5A)
 0.27A 4asdA-5grnA:
42.2		 4asdA-5grnA:
48.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 VAL A 607
ALA A 625
GLU A 644
ILE A 647
MET A 648
THR A 674
TYR A 676
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.97A 4bkjA-5grnA:
27.1		 4bkjA-5grnA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
ILE A 647
MET A 648
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.78A 4bkjB-5grnA:
26.9		 4bkjB-5grnA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.42A 4c8bA-5grnA:
19.7		 4c8bA-5grnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 5 VAL A 607
ILE A 657
TYR A 676
ILE A 834
 748  A1001 ( 4.7A)
748  A1001 ( 4.4A)
748  A1001 (-4.0A)
748  A1001 (-4.8A)
 0.41A 4c8bA-5grnA:
19.7		 4c8bA-5grnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 ALA A 625
LYS A 627
GLU A 644
ILE A 657
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.76A 4c8bB-5grnA:
19.9		 4c8bB-5grnA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 ALA A 625
LYS A 627
GLU A 644
ILE A 657
THR A 674
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 ( 4.4A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.48A 4c8bB-5grnA:
19.9		 4c8bB-5grnA:
27.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 10 LEU A 599
GLY A 600
GLY A 602
VAL A 607
ALA A 625
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.53A 4ckjA-5grnA:
25.4		 4ckjA-5grnA:
43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 VAL A 607
ALA A 625
GLU A 644
ILE A 647
MET A 648
VAL A 658
THR A 674
TYR A 676
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.68A 4csvA-5grnA:
26.8		 4csvA-5grnA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
THR A 674
TYR A 676
LEU A 825
ASP A 836
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.82A 4csvA-5grnA:
26.8		 4csvA-5grnA:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.64A 4hjoA-5grnA:
29.3		 4hjoA-5grnA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
 0.88A 4mxoA-5grnA:
25.0		 4mxoA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
ILE A 672
THR A 674
TYR A 676
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.66A 4mxoA-5grnA:
25.0		 4mxoA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.70A 4mxoB-5grnA:
25.0		 4mxoB-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.85A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.76A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.83A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.99A 4mxxA-5grnA:
24.8		 4mxxA-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.74A 4mxxB-5grnA:
24.3		 4mxxB-5grnA:
33.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
ILE A 672
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 1.06A 4mxyA-5grnA:
24.1		 4mxyA-5grnA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
VAL A 658
ILE A 672
TYR A 676
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.99A 4mxyA-5grnA:
24.1		 4mxyA-5grnA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
ILE A 672
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 1.06A 4mxzA-5grnA:
24.1		 4mxzA-5grnA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
GLU A 644
VAL A 658
ILE A 672
TYR A 676
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.99A 4mxzA-5grnA:
24.1		 4mxzA-5grnA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 11 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
ASN A 823
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
 0.68A 4o0sA-5grnA:
18.0		 4o0sA-5grnA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 6 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.3A)
 0.41A 4o0wA-5grnA:
15.6		 4o0wA-5grnA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 VAL A 607
ALA A 625
CYH A 677
ASP A 681
ASN A 823
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.5A)
None
None
748  A1001 (-4.3A)
 0.69A 4ogrI-5grnA:
15.8		 4ogrI-5grnA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
GLY A 600
GLY A 605
VAL A 607
ALA A 625
VAL A 658
LEU A 825
 748  A1001 (-3.8A)
None
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.3A)
 0.51A 4otiA-5grnA:
12.5		 4otiA-5grnA:
27.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
LYS A 627
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.71A 4otwA-5grnA:
24.0		 4otwA-5grnA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
LYS A 627
GLU A 644
ILE A 672
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.80A 4qmnA-5grnA:
18.5		 4qmnA-5grnA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 11 ALA A 625
LYS A 627
GLU A 644
ILE A 672
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.68A 4qmsA-5grnA:
18.5		 4qmsA-5grnA:
26.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ALA A 625
GLU A 644
MET A 648
LEU A 809
CYH A 814
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
 0.46A 4qrcA-5grnA:
26.2		 4qrcA-5grnA:
44.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		11 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
CYH A 677
CYH A 814
LEU A 825
ASP A 836
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 (-3.4A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.44A 4r7iA-5grnA:
42.3		 4r7iA-5grnA:
56.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 5 LEU A 599
VAL A 658
TYR A 676
ARG A 817
 748  A1001 (-3.8A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
None
 0.69A 4r7iA-5grnA:
42.3		 4r7iA-5grnA:
56.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.35A 4rzvB-5grnA:
20.8		 4rzvB-5grnA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
CYH A 814
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.77A 4tyjA-5grnA:
27.0		 4tyjA-5grnA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
MET A 648
CYH A 814
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.54A 4tyjA-5grnA:
27.0		 4tyjA-5grnA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 6 LEU A 599
VAL A 607
ILE A 657
ARG A 817
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 ( 4.4A)
None
748  A1001 (-4.8A)
 0.44A 4tyjA-5grnA:
27.0		 4tyjA-5grnA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 10 LEU A 599
VAL A 607
GLU A 644
LEU A 651
ILE A 657
VAL A 658
TYR A 676
ARG A 817
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.3A)
None
748  A1001 ( 4.4A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
None
748  A1001 (-4.8A)
 0.56A 4u0iA-5grnA:
33.9		 4u0iA-5grnA:
59.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		11 / 12 ALA A 625
LYS A 627
THR A 674
CYH A 677
GLY A 680
CYH A 814
HIS A 816
LEU A 825
CYH A 835
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.33A 4u0iA-5grnA:
33.9		 4u0iA-5grnA:
59.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
VAL A 607
ALA A 625
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.52A 4u5jB-5grnA:
25.4		 4u5jB-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
VAL A 607
ALA A 625
TYR A 676
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.79A 4u5jB-5grnA:
25.4		 4u5jB-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
ALA A 625
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.78A 4uxqA-5grnA:
27.2		 4uxqA-5grnA:
44.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
ALA A 625
LEU A 809
CYH A 814
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.33A 4uxqA-5grnA:
27.2		 4uxqA-5grnA:
44.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ALA A 625
GLU A 644
HIS A 816
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.85A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
MET A 648
LEU A 809
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.51A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
TYR A 676
CYH A 814
ARG A 817
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.81A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
VAL A 607
LYS A 627
TYR A 676
ARG A 817
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
 0.98A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
VAL A 607
TYR A 676
ARG A 817
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.71A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
GLU A 644
MET A 648
LEU A 809
CYH A 814
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.46A 4v01B-5grnA:
27.1		 4v01B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 9 LEU A 599
VAL A 607
LYS A 627
TYR A 676
ARG A 817
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.41A 4v01B-5grnA:
27.1		 4v01B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 9 LEU A 599
VAL A 607
LYS A 627
TYR A 676
LEU A 825
ILE A 657
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 ( 4.4A)
 1.08A 4v01B-5grnA:
27.1		 4v01B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 VAL A 607
ALA A 625
GLU A 644
LEU A 809
CYH A 814
HIS A 816
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.62A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 LYS A 627
MET A 648
TYR A 676
LEU A 825
 748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.68A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 MET A 648
TYR A 676
LEU A 825
ILE A 834
 748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.49A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 10 LEU A 599
VAL A 607
LYS A 627
MET A 648
TYR A 676
ARG A 817
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
 0.97A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 10 LEU A 599
VAL A 607
LYS A 627
MET A 648
TYR A 676
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.66A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ALA A 625
GLU A 644
HIS A 816
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.87A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
LEU A 809
CYH A 814
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.52A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 6 ARG A 597
LEU A 599
ALA A 625
LEU A 825
 None
748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.3A)
 0.74A 4wboC-5grnA:
16.5		 4wboC-5grnA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.62A 4wkqA-5grnA:
30.0		 4wkqA-5grnA:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
MET A 648
ILE A 672
THR A 674
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
 0.63A 4xeyB-5grnA:
26.3		 4xeyB-5grnA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
MET A 648
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.63A 4xeyB-5grnA:
26.3		 4xeyB-5grnA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
LYS A 627
MET A 648
VAL A 658
ILE A 672
THR A 674
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
 0.62A 4xeyB-5grnA:
26.3		 4xeyB-5grnA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
MET A 648
VAL A 658
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.61A 4xeyB-5grnA:
26.3		 4xeyB-5grnA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.70A 4xliA-5grnA:
26.1		 4xliA-5grnA:
33.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.80A 4xliA-5grnA:
26.1		 4xliA-5grnA:
33.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		11 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.79A 4xliB-5grnA:
25.3		 4xliB-5grnA:
33.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.36A 4xv2A-5grnA:
21.8		 4xv2A-5grnA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
ALA A 625
LYS A 627
CYH A 677
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.82A 5ajqA-5grnA:
3.3		 5ajqA-5grnA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
GLY A 600
ALA A 625
CYH A 677
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 (-3.7A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.88A 5ajqA-5grnA:
3.3		 5ajqA-5grnA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 7 ARG A 690
GLY A 893
SER A 890
LEU A 891
 None
 1.15A 5bphB-5grnA:
undetectable		 5bphB-5grnA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		10 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.56A 5bvwA-5grnA:
26.8		 5bvwA-5grnA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.35A 5cswA-5grnA:
21.9		 5cswA-5grnA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.42A 5cswB-5grnA:
26.5		 5cswB-5grnA:
28.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
ALA A 625
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.65A 5h2uC-5grnA:
24.2		 5h2uC-5grnA:
39.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
ALA A 625
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.61A 5h2uD-5grnA:
24.4		 5h2uD-5grnA:
39.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
VAL A 607
ALA A 625
ILE A 672
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.61A 5h2uD-5grnA:
24.4		 5h2uD-5grnA:
39.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 VAL A 607
ALA A 625
ILE A 672
THR A 674
TYR A 676
CYH A 835
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
 0.72A 5hesA-5grnA:
9.7		 5hesA-5grnA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 VAL A 607
ALA A 625
LYS A 627
ILE A 672
THR A 674
TYR A 676
CYH A 835
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
 0.67A 5hesB-5grnA:
17.9		 5hesB-5grnA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
LEU A 809
HIS A 816
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
 0.56A 5hi2A-5grnA:
18.6		 5hi2A-5grnA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 GLY A 838
ALA A 625
LYS A 627
ILE A 672
THR A 674
 None
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 0.80A 5hieA-5grnA:
10.0		 5hieA-5grnA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 VAL A 607
ALA A 625
LYS A 627
LEU A 645
ILE A 672
THR A 674
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
None
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 1.25A 5hieA-5grnA:
10.0		 5hieA-5grnA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 GLY A 838
ALA A 625
LYS A 627
ILE A 672
THR A 674
 None
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 0.81A 5hieB-5grnA:
26.0		 5hieB-5grnA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 607
ALA A 625
LYS A 627
ILE A 672
THR A 674
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 0.33A 5hieB-5grnA:
26.0		 5hieB-5grnA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 GLY A 600
VAL A 607
ALA A 625
LYS A 627
THR A 674
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
 0.46A 5hieC-5grnA:
21.1		 5hieC-5grnA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 GLY A 838
ALA A 625
LYS A 627
ILE A 672
THR A 674
 None
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 0.79A 5hieD-5grnA:
21.2		 5hieD-5grnA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 VAL A 607
ALA A 625
LYS A 627
ILE A 672
THR A 674
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
 0.33A 5hieD-5grnA:
21.2		 5hieD-5grnA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
LYS A 627
GLU A 644
ILE A 672
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.96A 5i9xA-5grnA:
32.9		 5i9xA-5grnA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
LYS A 627
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.69A 5i9xA-5grnA:
32.9		 5i9xA-5grnA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.86A 5i9yA-5grnA:
25.3		 5i9yA-5grnA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
LYS A 627
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.43A 5i9yA-5grnA:
25.3		 5i9yA-5grnA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 GLY A 600
VAL A 607
ALA A 625
VAL A 658
ASP A 681
LEU A 825
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
None
748  A1001 (-4.3A)
 0.55A 5l2iA-5grnA:
22.4		 5l2iA-5grnA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 GLY A 600
VAL A 607
ALA A 625
VAL A 658
ASP A 681
LEU A 825
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
None
748  A1001 (-4.3A)
 0.84A 5l2tA-5grnA:
6.7		 5l2tA-5grnA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 11 LEU A 599
GLY A 600
VAL A 607
ALA A 625
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.63A 5lvnA-5grnA:
23.2		 5lvnA-5grnA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 GLY A 600
VAL A 607
ALA A 625
LYS A 627
GLU A 644
TYR A 676
GLY A 680
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.73A 5mafA-5grnA:
23.1		 5mafA-5grnA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 10 LEU A 599
VAL A 607
LYS A 627
GLU A 644
ILE A 672
GLY A 680
PHE A 837
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.9A)
748  A1001 ( 4.0A)
748  A1001 (-3.7A)
 1.08A 5mo4A-5grnA:
23.0		 5mo4A-5grnA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
MET A 648
VAL A 658
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.61A 5mo4A-5grnA:
23.0		 5mo4A-5grnA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 10 LEU A 599
VAL A 607
ALA A 625
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.52A 5n3hA-5grnA:
14.7		 5n3hA-5grnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		3 / 3 VAL A 607
LYS A 623
MET A 622
 748  A1001 ( 4.7A)
CL  A1003 (-3.1A)
None
 0.99A 5nknA-5grnA:
undetectable		 5nknA-5grnA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ILE A 657
LEU A 651
VAL A 658
ASP A 836
HIS A 816
 748  A1001 ( 4.4A)
None
748  A1001 ( 4.8A)
748  A1001 (-4.8A)
748  A1001 (-3.8A)
 1.22A 5nnaA-5grnA:
undetectable		 5nnaA-5grnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ILE A 657
LEU A 651
VAL A 658
ASP A 836
HIS A 816
 748  A1001 ( 4.4A)
None
748  A1001 ( 4.8A)
748  A1001 (-4.8A)
748  A1001 (-3.8A)
 1.24A 5nnaB-5grnA:
undetectable		 5nnaB-5grnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 12 ILE A 657
LEU A 651
VAL A 658
ASP A 836
HIS A 816
 748  A1001 ( 4.4A)
None
748  A1001 ( 4.8A)
748  A1001 (-4.8A)
748  A1001 (-3.8A)
 1.19A 5nnaD-5grnA:
undetectable		 5nnaD-5grnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 8 ALA A 625
GLU A 644
CYH A 677
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 (-4.3A)
 0.42A 5owrA-5grnA:
2.1		 5owrA-5grnA:
27.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 GLY A 600
VAL A 607
ALA A 625
THR A 674
GLY A 680
ASN A 684
LEU A 825
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
None
748  A1001 (-4.3A)
 1.24A 5p9iA-5grnA:
24.6		 5p9iA-5grnA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 VAL A 607
ALA A 625
ILE A 672
THR A 674
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.77A 5p9iA-5grnA:
24.6		 5p9iA-5grnA:
35.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 ALA A 625
GLU A 644
MET A 648
VAL A 658
GLY A 680
LEU A 825
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.45A 5te0A-5grnA:
16.3		 5te0A-5grnA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		4 / 5 LEU A 599
VAL A 607
CYH A 677
CYH A 835
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.5A)
748  A1001 (-4.5A)
 0.56A 5te0A-5grnA:
16.3		 5te0A-5grnA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		6 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
 0.98A 5vcvA-5grnA:
22.2		 5vcvA-5grnA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.61A 5vcyA-5grnA:
22.1		 5vcyA-5grnA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		5 / 9 LEU A 599
ALA A 625
VAL A 658
CYH A 677
GLY A 680
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 ( 4.8A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
 0.69A 5w5vA-5grnA:
13.6		 5w5vA-5grnA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 ARG A 597
LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
CYH A 677
GLY A 680
LEU A 825
 None
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.67A 5y7zA-5grnA:
23.1		 5y7zA-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 ARG A 597
LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
CYH A 677
GLY A 680
LEU A 825
 None
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.67A 5y7zA-5grnA:
23.1		 5y7zA-5grnA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
ALA A 625
GLU A 644
CYH A 677
GLY A 680
LEU A 825
CYH A 835
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
 0.60A 5y7zB-5grnA:
23.2		 5y7zB-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
ALA A 625
LYS A 627
GLU A 644
CYH A 677
GLY A 680
CYH A 835
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.5A)
 0.71A 5y7zB-5grnA:
23.2		 5y7zB-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
THR A 674
CYH A 677
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.46A 5y80A-5grnA:
22.5		 5y80A-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
 0.53A 5y80A-5grnA:
22.5		 5y80A-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
TYR A 676
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.64A 5zv2A-5grnA:
26.5		 5zv2A-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 837
VAL A 607
ALA A 625
GLU A 644
MET A 648
TYR A 676
GLY A 680
 748  A1001 (-3.7A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
 0.95A 5zv2A-5grnA:
26.5		 5zv2A-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.0A)
 0.59A 5zv2B-5grnA:
26.5		 5zv2B-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		7 / 12 PHE A 837
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
GLY A 680
 748  A1001 (-3.7A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.0A)
 0.88A 5zv2B-5grnA:
26.5		 5zv2B-5grnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.60A 6bsdA-5grnA:
26.3		 6bsdA-5grnA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.62A 6hd4A-5grnA:
28.3		 6hd4A-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
 0.78A 6hd4A-5grnA:
28.3		 6hd4A-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.62A 6hd4B-5grnA:
28.3		 6hd4B-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
 0.85A 6hd4B-5grnA:
28.3		 6hd4B-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.63A 6hd6A-5grnA:
34.2		 6hd6A-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
 0.81A 6hd6A-5grnA:
34.2		 6hd6A-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		9 / 12 LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
THR A 674
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.70A 6hd6B-5grnA:
33.9		 6hd6B-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens) 		8 / 12 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
 0.88A 6hd6B-5grnA:
33.9		 6hd6B-5grnA:
14.16