SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5gru DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		6 / 12 TYR H 170
GLN H 223
PHE H 232
ASN L  36
ALA L  97
TRP L 106
 TYR  H 170 ( 1.3A)
GLN  H 223 ( 0.6A)
PHE  H 232 ( 1.3A)
ASN  L  36 ( 0.6A)
ALA  L  97 ( 0.0A)
TRP  L 106 ( 0.5A)
 0.74A 1h8sA-5gruH:
21.4		 1h8sA-5gruH:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5gru DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		6 / 12 TYR L 157
GLN L 210
PHE L 219
VAL H  37
ALA H  97
TRP H 119
 TYR  L 157 ( 1.3A)
GLN  L 210 ( 0.6A)
PHE  L 219 ( 1.3A)
VAL  H  37 ( 0.6A)
ALA  H  97 ( 0.0A)
TRP  H 119 ( 0.5A)
 0.72A 1h8sA-5gruL:
13.9		 1h8sA-5gruL:
26.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.07A 1ncwH-5gruL:
23.2
1ncwL-5gruL:
15.0		 1ncwH-5gruL:
52.94
1ncwL-5gruL:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 10 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.09A 1ruaH-5gruL:
23.5
1ruaL-5gruL:
20.5		 1ruaH-5gruL:
52.94
1ruaL-5gruL:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.11A 1rulH-5gruL:
23.1
1rulL-5gruL:
15.0		 1rulH-5gruL:
52.94
1rulL-5gruL:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.06A 1rumH-5gruL:
23.0
1rumL-5gruL:
15.0		 1rumH-5gruL:
52.94
1rumL-5gruL:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ASN L  36
TRP L  48
TYR L  51
GLY L 102
GLY H 225
 ASN  L  36 ( 0.6A)
TRP  L  48 ( 0.5A)
TYR  L  51 ( 1.3A)
GLY  L 102 ( 0.0A)
GLY  H 225 ( 0.0A)
 1.07A 1rupH-5gruL:
23.1
1rupL-5gruL:
15.1		 1rupH-5gruL:
52.94
1rupL-5gruL:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 11 GLY L 109
THR L  93
GLN L  40
GLN H 172
PHE H 221
 GLY  L 109 ( 0.0A)
THR  L  93 ( 0.8A)
GLN  L  40 ( 0.6A)
GLN  H 172 ( 0.6A)
PHE  H 221 ( 1.3A)
 1.38A 2dr2A-5gruL:
undetectable		 2dr2A-5gruL:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5gru DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 9 ILE L 217
ASP H 117
GLY H  99
TYR L 176
THR H 103
 ILE  L 217 ( 0.7A)
ASP  H 117 ( 0.6A)
GLY  H  99 ( 0.0A)
TYR  L 176 ( 1.3A)
THR  H 103 ( 0.8A)
 1.47A 2tsrD-5gruL:
undetectable		 2tsrD-5gruL:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5gru DIABODY PROTEIN
(Mus
musculus) 		3 / 3 SER L 215
THR L 218
PHE L 192
 SER  L 215 ( 0.0A)
THR  L 218 ( 0.8A)
PHE  L 192 ( 1.3A)
 0.64A 2x91A-5gruL:
undetectable		 2x91A-5gruL:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		4 / 8 GLY L 109
ILE L  38
VAL H 178
GLN H 172
 GLY  L 109 ( 0.0A)
ILE  L  38 ( 0.7A)
VAL  H 178 ( 0.6A)
GLN  H 172 ( 0.6A)
 0.63A 3fi0G-5gruL:
undetectable		 3fi0G-5gruL:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 TRP L  48
GLY H 225
THR H 227
PHE L 103
ILE L 101
 TRP  L  48 ( 0.5A)
GLY  H 225 ( 0.0A)
THR  H 227 ( 0.8A)
PHE  L 103 ( 1.3A)
ILE  L 101 ( 0.7A)
 1.22A 3iv6A-5gruL:
undetectable		 3iv6A-5gruL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 TRP L  48
GLY H 225
THR H 227
PHE L 103
ILE L 101
 TRP  L  48 ( 0.5A)
GLY  H 225 ( 0.0A)
THR  H 227 ( 0.8A)
PHE  L 103 ( 1.3A)
ILE  L 101 ( 0.7A)
 1.20A 3iv6B-5gruL:
undetectable		 3iv6B-5gruL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 TRP L  48
GLY H 225
THR H 227
PHE L 103
ILE L 101
 TRP  L  48 ( 0.5A)
GLY  H 225 ( 0.0A)
THR  H 227 ( 0.8A)
PHE  L 103 ( 1.3A)
ILE  L 101 ( 0.7A)
 1.28A 3iv6C-5gruL:
undetectable		 3iv6C-5gruL:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 TRP L  48
GLY H 225
THR H 227
PHE L 103
ILE L 101
 TRP  L  48 ( 0.5A)
GLY  H 225 ( 0.0A)
THR  H 227 ( 0.8A)
PHE  L 103 ( 1.3A)
ILE  L 101 ( 0.7A)
 1.24A 3iv6D-5gruL:
undetectable		 3iv6D-5gruL:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5gru DIABODY PROTEIN
(Mus
musculus) 		5 / 12 ALA L 153
SER L 214
SER L 215
MET L 125
ALA L 146
 ALA  L 153 ( 0.0A)
SER  L 214 ( 0.0A)
SER  L 215 ( 0.0A)
MET  L 125 ( 0.0A)
ALA  L 146 ( 0.0A)
 1.25A 3qxvE-5gruL:
16.2		 3qxvE-5gruL:
44.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5gru DIABODY PROTEIN
(Homo
sapiens) 		4 / 4 LEU H 149
GLY H 150
LEU H 212
GLU H 213
 LEU  H 149 ( 0.6A)
GLY  H 150 ( 0.0A)
LEU  H 212 ( 0.6A)
GLU  H 213 ( 0.6A)
 0.95A 3tgvB-5gruH:
undetectable		 3tgvB-5gruH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5gru DIABODY PROTEIN
(Homo
sapiens) 		4 / 5 GLY H  99
TYR H 102
TYR H 100
GLU H 113
 GLY  H  99 ( 0.0A)
TYR  H 102 ( 1.3A)
TYR  H 100 ( 1.3A)
GLU  H 113 ( 0.6A)
 1.20A 4ae1B-5gruH:
3.9		 4ae1B-5gruH:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 THR H 219
GLY H 176
LEU L 111
ALA L  92
THR L  91
 THR  H 219 ( 0.8A)
GLY  H 176 ( 0.0A)
LEU  L 111 ( 0.6A)
ALA  L  92 ( 0.0A)
THR  L  91 ( 0.8A)
 1.03A 4uckB-5gruH:
undetectable		 4uckB-5gruH:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 PHE L 103
GLN H 223
GLN H 224
GLY H 225
LEU H 228
 PHE  L 103 ( 1.3A)
GLN  H 223 ( 0.6A)
GLN  H 224 ( 0.6A)
GLY  H 225 ( 0.0A)
LEU  H 228 ( 0.6A)
 0.62A 4uilH-5gruL:
18.6
4uilL-5gruL:
19.3		 4uilH-5gruL:
35.54
4uilL-5gruL:
66.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5gru DIABODY PROTEIN
(Mus
musculus) 		4 / 8 ARG L  67
VAL L  86
ASP L  89
ASP L  90
 ARG  L  67 ( 0.6A)
VAL  L  86 ( 0.6A)
ASP  L  89 ( 0.6A)
ASP  L  90 ( 0.6A)
 0.90A 4xqgA-5gruL:
undetectable		 4xqgA-5gruL:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5gru DIABODY PROTEIN
(Mus
musculus) 		4 / 8 ARG L  67
VAL L  86
ASP L  89
ASP L  90
 ARG  L  67 ( 0.6A)
VAL  L  86 ( 0.6A)
ASP  L  89 ( 0.6A)
ASP  L  90 ( 0.6A)
 0.89A 4xqgB-5gruL:
undetectable		 4xqgB-5gruL:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5gru DIABODY PROTEIN
DIABODY PROTEIN
(Homo
sapiens;
Mus
musculus) 		3 / 3 GLY H 130
GLN H  13
LYS L  65
 GLY  H 130 ( 0.0A)
GLN  H  13 ( 0.6A)
LYS  L  65 ( 0.0A)
 0.94A 5imsB-5gruH:
undetectable		 5imsB-5gruH:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5gru DIABODY PROTEIN
(Mus
musculus) 		4 / 8 THR L 195
SER L 184
THR L 193
SER L 186
 THR  L 195 ( 0.8A)
SER  L 184 ( 0.0A)
THR  L 193 ( 0.8A)
SER  L 186 ( 0.0A)
 0.97A 5l4eA-5gruL:
undetectable
5l4eB-5gruL:
2.6
5l4eC-5gruL:
undetectable
5l4eD-5gruL:
undetectable
5l4eE-5gruL:
undetectable		 5l4eA-5gruL:
20.37
5l4eB-5gruL:
20.37
5l4eC-5gruL:
20.37
5l4eD-5gruL:
20.37
5l4eE-5gruL:
20.37