SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5grv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN
HOMO-SPECIFIC
DIABODY LIGHT CHAIN
(Homo
sapiens) 		5 / 11 TRP L  46
SER L  49
TYR L  58
GLY L 100
PRO K 220
 None
 1.15A 1i9jH-5grvL:
22.1
1i9jL-5grvL:
14.6		 1i9jH-5grvL:
51.50
1i9jL-5grvL:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 5grv HOMO-SPECIFIC
DIABODY LIGHT CHAIN
(Homo
sapiens) 		5 / 10 ALA K 158
TYR K 160
LEU K 170
TYR K 173
HIS K 213
 None
 0.61A 1jglH-5grvK:
17.0
1jglL-5grvK:
21.7		 1jglH-5grvK:
25.37
1jglL-5grvK:
33.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN
HOMO-SPECIFIC
DIABODY LIGHT CHAIN
(Homo
sapiens) 		5 / 12 TRP L  46
SER L  49
TYR L  58
GLY L 100
PRO K 220
 None
 1.16A 1vpoH-5grvL:
22.3
1vpoL-5grvL:
14.3		 1vpoH-5grvL:
54.27
1vpoL-5grvL:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5grv HOMO-SPECIFIC
DIABODY LIGHT CHAIN
HOMO-SPECIFIC
DIABODY HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY L 103
ALA K 158
ALA L 104
TYR K 160
ARG L  97
 None
 1.17A 2avdA-5grvL:
undetectable		 2avdA-5grvL:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5grv HOMO-SPECIFIC
DIABODY LIGHT CHAIN
HOMO-SPECIFIC
DIABODY HEAVY CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY L 103
ALA K 158
ASP L 106
ALA L 104
TYR K 160
 None
 1.15A 2avdB-5grvL:
undetectable		 2avdB-5grvL:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5grv HOMO-SPECIFIC
DIABODY LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PRO K 168
TYR K 211
HIS K 213
TYR K 160
 None
 1.21A 2ombC-5grvK:
17.9
2ombD-5grvK:
17.9		 2ombC-5grvK:
29.19
2ombD-5grvK:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL L  36
VAL L  47
PHE L  98
ARG L  37
 None
 1.19A 3bjwF-5grvL:
undetectable		 3bjwF-5grvL:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN
(Homo
sapiens) 		5 / 10 ILE L  86
ALA L  87
ASP L  89
THR L  90
LEU L  17
 None
 1.07A 4kq8A-5grvL:
undetectable		 4kq8A-5grvL:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA L  91
THR L  90
VAL L 114
GLU L  88
 None
 0.72A 5ecmD-5grvL:
undetectable		 5ecmD-5grvL:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5grv HOMO-SPECIFIC
DIABODY HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA L  91
THR L  90
VAL L 114
GLU L  88
 None
 0.81A 5ecoD-5grvL:
undetectable		 5ecoD-5grvL:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5grv HOMO-SPECIFIC
DIABODY LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR K 198
SER K 187
THR K 196
SER K 189
 None
 0.98A 5l4eA-5grvK:
undetectable
5l4eB-5grvK:
undetectable
5l4eC-5grvK:
undetectable
5l4eD-5grvK:
undetectable
5l4eE-5grvK:
undetectable		 5l4eA-5grvK:
18.10
5l4eB-5grvK:
18.10
5l4eC-5grvK:
18.10
5l4eD-5grvK:
18.10
5l4eE-5grvK:
18.10