SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gs0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 386
LEU A 414
ASN A 413
LEU A 438
LEU A 404
 None
None
NAG  A 814 (-2.6A)
None
None
 1.32A 1a28B-5gs0A:
undetectable		 1a28B-5gs0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5gs0 LIGHT CHAIN
(ANTI-TLR3)
(Mus
musculus) 		4 / 8 VAL C 106
ARG C  60
ALA C  18
GLU C  82
 None
 0.99A 1dmiA-5gs0C:
undetectable
1dmiB-5gs0C:
undetectable		 1dmiA-5gs0C:
13.83
1dmiB-5gs0C:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5gs0 HEAVY CHAIN
(ANTI-LID)
(Mus
musculus) 		4 / 6 SER X  28
GLY X  56
THR X  74
ILE X  52
 None
 0.92A 1gtnD-5gs0X:
undetectable
1gtnE-5gs0X:
undetectable		 1gtnD-5gs0X:
20.93
1gtnE-5gs0X:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 11 PHE A 143
LEU A 176
LEU A 164
SER A 160
ILE A 183
 None
 0.99A 1ha2A-5gs0A:
undetectable		 1ha2A-5gs0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 6 LEU A  77
LEU A  98
PRO A  99
MET A 100
 None
None
None
NAG  A 803 (-3.8A)
 1.23A 1hz4A-5gs0A:
undetectable		 1hz4A-5gs0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5gs0 HEAVY CHAIN
(ANTI-LID)
(Mus
musculus) 		4 / 8 ILE X  70
PHE X  79
VAL X  24
SER X   7
 None
 1.17A 1kb9A-5gs0X:
undetectable
1kb9C-5gs0X:
undetectable
1kb9D-5gs0X:
undetectable
1kb9E-5gs0X:
undetectable		 1kb9A-5gs0X:
14.05
1kb9C-5gs0X:
13.95
1kb9D-5gs0X:
21.52
1kb9E-5gs0X:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 4 HIS A 319
ALA A 295
PHE A 294
GLY A 320
 None
 1.40A 1mj2B-5gs0A:
undetectable		 1mj2B-5gs0A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 4 HIS A 319
ALA A 295
PHE A 294
GLY A 320
 None
 1.42A 1mjoD-5gs0A:
undetectable		 1mjoD-5gs0A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 5gs0 LIGHT CHAIN
(ANTI-TLR3)
HEAVY CHAIN
(ANTI-TLR3)
(Mus
musculus;
Mus
musculus) 		5 / 12 ALA D  35
VAL C  97
SER C  89
ASN D  62
PRO C  93
 None
 1.08A 1sg9C-5gs0D:
undetectable		 1sg9C-5gs0D:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 471
PHE A 476
SER A 500
PRO A 504
LEU A 508
 None
 1.25A 1u72A-5gs0A:
undetectable		 1u72A-5gs0A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 10 LEU A 128
ILE A 138
PRO A 142
LEU A 114
ILE A 135
 None
 1.06A 1yi4A-5gs0A:
undetectable		 1yi4A-5gs0A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 7 LEU A 279
PHE A 303
THR A 262
LEU A 260
 None
 1.00A 2eikA-5gs0A:
undetectable
2eikJ-5gs0A:
undetectable		 2eikA-5gs0A:
21.21
2eikJ-5gs0A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 7 LYS A 147
LEU A 149
LEU A 128
PHE A 119
 None
 1.08A 2eimC-5gs0A:
undetectable
2eimJ-5gs0A:
undetectable		 2eimC-5gs0A:
15.66
2eimJ-5gs0A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5gs0 TOLL-LIKE RECEPTOR 3
LIGHT CHAIN
(ANTI-TLR3)
(Homo
sapiens;
Mus
musculus) 		4 / 4 ASP A 116
ASP C  50
ASP C  91
GLY C  28
 None
 1.47A 2igtC-5gs0A:
undetectable		 2igtC-5gs0A:
17.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5gs0 LIGHT CHAIN
(ANTI-TLR3)
HEAVY CHAIN
(ANTI-TLR3)
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR C  35
PRO C  43
TYR C  86
TYR D  98
 None
 0.67A 2oldA-5gs0C:
19.3
2oldB-5gs0C:
19.2		 2oldA-5gs0C:
59.13
2oldB-5gs0C:
59.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5gs0 LIGHT CHAIN
(ANTI-TLR3)
HEAVY CHAIN
(ANTI-TLR3)
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR D  98
TYR C  35
PRO C  43
TYR C  86
 None
 0.71A 2oldA-5gs0D:
13.5
2oldB-5gs0D:
13.5		 2oldA-5gs0D:
23.58
2oldB-5gs0D:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5gs0 HEAVY CHAIN
(ANTI-LID)
(Mus
musculus) 		5 / 12 GLN X  78
THR X  21
ARG X  98
ILE X  29
PHE X  79
 None
 1.45A 2vdyB-5gs0X:
undetectable		 2vdyB-5gs0X:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ILE A 367
LEU A 360
ILE A 346
PHE A 333
 None
 0.76A 2w9sE-5gs0A:
undetectable		 2w9sE-5gs0A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 LEU A 279
PHE A 303
THR A 262
LEU A 260
 None
 0.94A 3ag3N-5gs0A:
undetectable
3ag3W-5gs0A:
undetectable		 3ag3N-5gs0A:
21.21
3ag3W-5gs0A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 5 SER A 205
LEU A 199
GLY A 225
GLU A 203
 None
 1.13A 3aiaA-5gs0A:
undetectable
3aiaB-5gs0A:
undetectable		 3aiaA-5gs0A:
15.62
3aiaB-5gs0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 386
LEU A 412
ASN A 413
LEU A 436
LEU A 381
 None
None
NAG  A 814 (-2.6A)
None
None
 1.41A 3d90A-5gs0A:
undetectable		 3d90A-5gs0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 386
LEU A 414
ASN A 413
LEU A 438
LEU A 404
 None
None
NAG  A 814 (-2.6A)
None
None
 1.29A 3d90A-5gs0A:
undetectable		 3d90A-5gs0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 233
THR A 267
LEU A 279
LEU A 253
PHE A 212
 None
 1.33A 3g1uB-5gs0A:
undetectable		 3g1uB-5gs0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 233
THR A 267
LEU A 279
LEU A 253
PHE A 212
 None
 1.33A 3g1uD-5gs0A:
undetectable		 3g1uD-5gs0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 GLU A 570
ASN A 572
ASN A 568
ILE A 591
 None
 1.15A 3kp6A-5gs0A:
undetectable
3kp6B-5gs0A:
undetectable		 3kp6A-5gs0A:
12.82
3kp6B-5gs0A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 233
THR A 267
LEU A 279
LEU A 253
PHE A 212
 None
 1.27A 3n58D-5gs0A:
undetectable		 3n58D-5gs0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 SER A 317
GLN A 352
ASN A 291
TRP A 353
 None
None
NAG  A 810 (-2.7A)
None
 1.12A 3n62A-5gs0A:
undetectable		 3n62A-5gs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 SER A 317
GLN A 352
ASN A 291
TRP A 353
 None
None
NAG  A 810 (-2.7A)
None
 1.08A 3n66B-5gs0A:
undetectable		 3n66B-5gs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 PHE A 333
SER A 332
SER A 389
LEU A 384
PHE A 351
 None
 1.40A 3u9fD-5gs0A:
undetectable
3u9fE-5gs0A:
undetectable		 3u9fD-5gs0A:
16.09
3u9fE-5gs0A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 PHE A 333
SER A 332
SER A 389
LEU A 384
PHE A 351
 None
 1.35A 3u9fG-5gs0A:
undetectable
3u9fH-5gs0A:
undetectable		 3u9fG-5gs0A:
16.09
3u9fH-5gs0A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5gs0 LIGHT CHAIN
(ANTI-TLR3)
(Mus
musculus) 		4 / 8 THR C  73
TYR C  85
TRP C  34
ARG C  19
 None
 1.38A 3wipB-5gs0C:
undetectable
3wipC-5gs0C:
undetectable		 3wipB-5gs0C:
22.17
3wipC-5gs0C:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5gs0 HEAVY CHAIN
(ANTI-LID)
(Mus
musculus) 		3 / 3 ARG X  67
ARG X  39
ASP X  89
 None
 0.94A 3wipG-5gs0X:
undetectable
3wipH-5gs0X:
undetectable		 3wipG-5gs0X:
18.94
3wipH-5gs0X:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ASP A 366
SER A 389
ASN A 388
GLY A 369
 None
 1.03A 4af0A-5gs0A:
undetectable		 4af0A-5gs0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 6 LEU A 202
LEU A 204
ILE A 209
THR A 162
 None
 0.99A 4do3B-5gs0A:
undetectable		 4do3B-5gs0A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5gs0 HEAVY CHAIN
(ANTI-LID)
(Mus
musculus) 		4 / 4 ILE X  68
LEU X  64
LYS X  65
ASN X  84
 None
 1.34A 4g19D-5gs0X:
undetectable		 4g19D-5gs0X:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 7 SER A 317
GLN A 352
ASN A 291
TRP A 353
 None
None
NAG  A 810 (-2.7A)
None
 1.14A 4kcnB-5gs0A:
undetectable		 4kcnB-5gs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 PHE A 401
ILE A 422
LEU A 438
LEU A 409
LEU A 430
 None
 1.34A 4qynB-5gs0A:
undetectable		 4qynB-5gs0A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 9 ASN A 441
ILE A 443
GLY A 439
SER A 514
VAL A 490
 None
 1.10A 4r20B-5gs0A:
undetectable		 4r20B-5gs0A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 5gs0 LIGHT CHAIN
(ANTI-TLR3)
TOLL-LIKE RECEPTOR 3
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU A 164
GLU A 190
ILE A 135
PRO C  93
 None
 0.91A 4xi3C-5gs0A:
undetectable		 4xi3C-5gs0A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 10 GLY A 594
ASN A 645
ALA A 633
ILE A 591
LEU A 593
 None
 1.12A 4xj7A-5gs0A:
undetectable
4xj7B-5gs0A:
undetectable		 4xj7A-5gs0A:
15.48
4xj7B-5gs0A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 10 LEU A 593
GLY A 594
ASN A 645
ALA A 633
ILE A 591
 None
 1.14A 4xj7C-5gs0A:
undetectable
4xj7D-5gs0A:
undetectable		 4xj7C-5gs0A:
15.48
4xj7D-5gs0A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5gs0 HEAVY CHAIN
(ANTI-LID)
(Mus
musculus) 		4 / 8 ARG X  67
VAL X  86
ASP X  89
ASP X  90
 None
 0.78A 4xqgA-5gs0X:
undetectable		 4xqgA-5gs0X:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5gs0 HEAVY CHAIN
(ANTI-LID)
(Mus
musculus) 		4 / 8 ARG X  67
VAL X  86
ASP X  89
ASP X  90
 None
 0.77A 4xqgB-5gs0X:
undetectable		 4xqgB-5gs0X:
12.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5gs0 LIGHT CHAIN
(ANTI-TLR3)
(Mus
musculus) 		5 / 7 TYR C  31
TYR C  35
TYR C  48
GLU C  49
PRO C  54
 None
 1.14A 5aclA-5gs0C:
19.5		 5aclA-5gs0C:
60.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		3 / 3 ASN A 230
SER A 205
SER A 179
 None
 0.64A 5gsnA-5gs0A:
undetectable		 5gsnA-5gs0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 11 ILE A 591
TRP A 546
PHE A 606
LEU A 612
LEU A 569
 None
 1.23A 5ji0A-5gs0A:
undetectable		 5ji0A-5gs0A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 5 ILE A 668
MET A 642
GLN A 618
ARG A 643
 None
 1.47A 5jm4A-5gs0A:
undetectable		 5jm4A-5gs0A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 6 GLY A 594
SER A 571
GLY A 573
ASN A 620
 None
 0.91A 5k4pA-5gs0A:
undetectable		 5k4pA-5gs0A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 4 ASN A 466
LEU A 469
SER A 464
LEU A 485
 None
 1.39A 5kb5A-5gs0A:
undetectable		 5kb5A-5gs0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 SER A 317
GLN A 352
ASN A 291
TRP A 353
 None
None
NAG  A 810 (-2.7A)
None
 1.13A 5vuoB-5gs0A:
undetectable		 5vuoB-5gs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5gs0 HEAVY CHAIN
(ANTI-TLR3)
(Mus
musculus) 		6 / 12 GLY D  51
ASN D  61
VAL D  67
ILE D  39
LEU D  50
LEU D  86
 None
 1.34A 5wy0A-5gs0D:
undetectable		 5wy0A-5gs0D:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 7 LEU A 255
MET A 278
THR A 277
LEU A 276
 None
NAG  A 806 (-4.3A)
None
None
 0.88A 5xdqA-5gs0A:
undetectable
5xdqJ-5gs0A:
undetectable		 5xdqA-5gs0A:
21.21
5xdqJ-5gs0A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 7 LEU A 281
MET A 278
THR A 277
LEU A 300
 None
NAG  A 806 (-4.3A)
None
None
 0.92A 5xdqA-5gs0A:
undetectable
5xdqJ-5gs0A:
undetectable		 5xdqA-5gs0A:
21.21
5xdqJ-5gs0A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 SER A 389
PHE A 375
MET A 374
LEU A 412
 None
 1.06A 5y2tB-5gs0A:
undetectable		 5y2tB-5gs0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 8 SER A 317
GLN A 352
ASN A 291
TRP A 353
 None
None
NAG  A 810 (-2.7A)
None
 1.12A 6auuB-5gs0A:
undetectable		 6auuB-5gs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 10 LEU A 271
LEU A 281
ILE A 250
SER A 254
GLY A 225
 None
 1.26A 6dm0B-5gs0A:
undetectable
6dm0C-5gs0A:
undetectable		 6dm0B-5gs0A:
9.93
6dm0C-5gs0A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 4 ILE A 668
MET A 642
GLN A 618
ARG A 643
 None
 1.47A 6fn9B-5gs0A:
0.0		 6fn9B-5gs0A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		4 / 6 VAL A 581
ASN A 550
PRO A 554
ILE A 555
 None
 1.13A 6h7uA-5gs0A:
undetectable		 6h7uA-5gs0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5gs0 TOLL-LIKE RECEPTOR 3
(Homo
sapiens) 		5 / 12 ASN A 413
ILE A 461
ILE A 458
TRP A 452
PHE A 427
 NAG  A 814 (-2.6A)
None
None
None
None
 1.20A 6hlpA-5gs0A:
undetectable		 6hlpA-5gs0A:
22.24