SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5gs1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 5gs1 DIABODY
(Homo
sapiens) 		5 / 10 ALA C 158
TYR C 160
LEU C 170
TYR C 173
HIS C 213
 None
 0.63A 1jglH-5gs1C:
17.5
1jglL-5gs1C:
18.9		 1jglH-5gs1C:
37.92
1jglL-5gs1C:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 5gs1 LIGHT CHAIN
(Homo
sapiens) 		5 / 10 ALA A  35
TYR A  37
LEU A  47
TYR A  50
HIS A  90
 None
 0.62A 1jglH-5gs1A:
17.1
1jglL-5gs1A:
21.9		 1jglH-5gs1A:
20.47
1jglL-5gs1A:
59.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5gs1 DIABODY
(Homo
sapiens) 		4 / 7 PRO C 168
TYR C 211
HIS C 213
TYR C 160
 None
 1.15A 2ombC-5gs1C:
13.7
2ombD-5gs1C:
14.0		 2ombC-5gs1C:
27.08
2ombD-5gs1C:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5gs1 LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PRO A  45
TYR A  88
HIS A  90
TYR A  37
 None
 1.18A 2ombC-5gs1A:
17.8
2ombD-5gs1A:
17.8		 2ombC-5gs1A:
26.67
2ombD-5gs1A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5gs1 DIABODY
(Homo
sapiens) 		4 / 6 VAL C  36
VAL C  47
PHE C  98
ARG C  37
 None
 1.19A 3bjwF-5gs1C:
undetectable		 3bjwF-5gs1C:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5gs1 DIABODY
(Homo
sapiens) 		4 / 8 THR C 198
SER C 187
THR C 196
SER C 189
 None
 0.99A 5l4eA-5gs1C:
undetectable
5l4eB-5gs1C:
undetectable
5l4eC-5gs1C:
undetectable
5l4eD-5gs1C:
undetectable
5l4eE-5gs1C:
undetectable		 5l4eA-5gs1C:
20.06
5l4eB-5gs1C:
20.06
5l4eC-5gs1C:
20.06
5l4eD-5gs1C:
20.06
5l4eE-5gs1C:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5gs1 LIGHT CHAIN
(Homo
sapiens) 		4 / 8 THR A  75
SER A  64
THR A  73
SER A  66
 None
 0.94A 5l4eA-5gs1A:
undetectable
5l4eB-5gs1A:
undetectable
5l4eC-5gs1A:
undetectable
5l4eD-5gs1A:
undetectable
5l4eE-5gs1A:
undetectable		 5l4eA-5gs1A:
17.59
5l4eB-5gs1A:
17.59
5l4eC-5gs1A:
17.59
5l4eD-5gs1A:
17.59
5l4eE-5gs1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5gs1 LIGHT CHAIN
(Homo
sapiens) 		3 / 3 ARG A  46
PRO A  60
TYR A  87
 None
 1.09A 5tzoB-5gs1A:
undetectable		 5tzoB-5gs1A:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 5gs1 DIABODY
(Homo
sapiens) 		3 / 3 TYR C  59
GLY C  65
THR C  68
 None
 0.18A 6cjkB-5gs1C:
19.6		 6cjkB-5gs1C:
42.86